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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1959 2
1960 4
1961 1
1962 1
1964 1
1965 7
1966 11
1967 23
1968 32
1969 26
1970 36
1971 26
1972 32
1973 33
1974 34
1975 31
1976 29
1977 38
1978 37
1979 31
1980 35
1981 48
1982 46
1983 50
1984 56
1985 75
1986 77
1987 87
1988 97
1989 126
1990 137
1991 147
1992 183
1993 226
1994 245
1995 238
1996 229
1997 272
1998 309
1999 326
2000 373
2001 387
2002 392
2003 478
2004 496
2005 576
2006 570
2007 562
2008 656
2009 670
2010 733
2011 954
2012 1039
2013 1265
2014 1437
2015 1602
2016 1389
2017 1443
2018 1382
2019 688
2020 17
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18,772 results
Results by year
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Page 1
A Protein-Truncating HSD17B13 Variant and Protection from Chronic Liver Disease.
Abul-Husn NS, et al. N Engl J Med 2018. PMID 29562163 Free PMC article.
Variants that were replicated in three additional cohorts (12,527 persons) were evaluated for association with clinical diagnoses of chronic liver disease in DiscovEHR study participants and two independent cohorts (total of 37,173 persons) and with histopathological severity of liver disease in 2391 human liver samples. ...CONCLUSIONS: A loss-of-function variant in HSD17B13 was associated with a reduced risk of chronic liver disease and of progression from steatosis to steatohepatitis. ...
Variants that were replicated in three additional cohorts (12,527 persons) were evaluated for association with clinical diagnoses of chronic …
Genetics of liver disease: From pathophysiology to clinical practice.
Karlsen TH, et al. J Hepatol 2015 - Review. PMID 25920091 Free article.
During the 1990 s, developments in genomic technologies drove the identification of genes responsible for Mendelian liver diseases. ...In the immediate future genetics will allow further stratification of liver diseases and contribute to personalized medicine. ...
During the 1990 s, developments in genomic technologies drove the identification of genes responsible for Mendelian liver diseases
Analysis of the mechanism underlying liver diseases using human induced pluripotent stem cells.
Kakinuma S and Watanabe M. Immunol Med 2019 - Review. PMID 31498713
Results of recent studies have shown that disease models using human induced pluripotent stem (iPS) cells have recapitulated the pathophysiology of genetic liver diseases, viral hepatitis and hepatic fibrosis. ...The co-culture of human iPS-derived hepatocytes and mesenchyme partially mimics the process of liver fibrosis. Human iPS cell-derived hepatic cells and the co-culture system of such cells will contribute to the progress of studies on the pathophysiology of genetic and non-genetic liver diseases and development of novel therapeutic strategies for treating liver diseases....
Results of recent studies have shown that disease models using human induced pluripotent stem (iPS) cells have recapitulated the path …
Molecular Mechanisms Driving Progression of Liver Cirrhosis towards Hepatocellular Carcinoma in Chronic Hepatitis B and C Infections: A Review.
Kanda T, et al. Int J Mol Sci 2019 - Review. PMID 30889843 Free PMC article.
Almost all patients with hepatocellular carcinoma (HCC), a major type of primary liver cancer, also have liver cirrhosis, the severity of which hampers effective treatment for HCC despite recent progress in the efficacy of anticancer drugs for advanced stages of HCC. Here, we review recent knowledge concerning the molecular mechanisms of liver cirrhosis and its progression to HCC from genetic and epigenomic points of view. ...
Almost all patients with hepatocellular carcinoma (HCC), a major type of primary liver cancer, also have liver cirrhosis, the …
Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets
Schulze K, et al. Nat Genet 2015. PMID 25822088 Free PMC article.
Exome sequencing analysis of 243 liver tumors identified mutational signatures associated with specific risk factors, mainly combined alcohol and tobacco consumption and exposure to aflatoxin B1. ...
Exome sequencing analysis of 243 liver tumors identified mutational signatures associated with specific risk factors, mainly combined …
Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis.
Kettner NM, et al. Cancer Cell 2016. PMID 27889186 Free PMC article.
The process initiates with non-alcoholic fatty liver disease (NAFLD) that progresses to steatohepatitis and fibrosis before HCC detection. This pathophysiological pathway is driven by jet-lag-induced genome-wide gene deregulation and global liver metabolic dysfunction, with nuclear receptor-controlled cholesterol/bile acid and xenobiotic metabolism among the top deregulated pathways. ...
The process initiates with non-alcoholic fatty liver disease (NAFLD) that progresses to steatohepatitis and fibrosis before HC …
The genetic backgrounds in nonalcoholic fatty liver disease.
Seko Y, et al. Clin J Gastroenterol 2018 - Review. PMID 29492830
Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease worldwide. Nonalcoholic steatohepatitis (NASH), a severe form of NAFLD, can lead to hepatocellular carcinoma (HCC) and hepatic failure. ...The transmembrane 6 superfamily member 2 (TM6SF2) gene variant E167 K was also associated with NAFLD, and it has a relationship with cardiovascular disease. ...
Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease worldwide. Nonalcoholic ste …
Genetics of autoimmune liver disease: a brief summary for clinicians.
Webb GJ and Hirschfield GM. Dig Dis 2014 - Review. PMID 25160582
Autoimmune liver diseases are rare chronic immune-mediated liver injuries in which the consequences of hepatic and biliary inflammation are cirrhosis and end-stage liver disease. Epidemiological surveys of individuals, families and populations strongly support a model of disease for which environmental and genetic influences are highly relevant to why any individual develops disease. ...
Autoimmune liver diseases are rare chronic immune-mediated liver injuries in which the consequences of hepatic and bili …
Epigenetics in non-alcoholic fatty liver disease.
Lee J, et al. Mol Aspects Med 2017 - Review. PMID 27889327
Non-alcoholic fatty liver disease (NAFLD), a common hepatic disorder ranging from simple steatosis through steatohepatitis to fibrosis and cirrhosis, is an emerging health concern. NAFLD is a pathologic condition characterized by the buildup of extra fat in liver cells that is not caused by alcohol consumption. ...
Non-alcoholic fatty liver disease (NAFLD), a common hepatic disorder ranging from simple steatosis through steatohepatitis to …
Comparative analysis of gene expression profiles of OPN signaling pathway in four kinds of liver diseases.
Wang G, et al. J Genet 2016 - Review. PMID 27659347 Free article.
To explore the relevance of OPN signalling pathway to the occurrence and development of nonalcoholic fatty liver disease (NAFLD), liver cirrhosis (LC), hepatic cancer (HC) and acute hepatic failure (AHF) at transcriptional level, Rat Genome 230 2.0 Array was used to detect expression profiles of OPN signalling pathway-related genes in four kinds of liver diseases. The results showed that 23, 33, 59 and 74 genes were significantly changed in the above four kinds of liver diseases, respectively. ...
To explore the relevance of OPN signalling pathway to the occurrence and development of nonalcoholic fatty liver disease (NAFL …
18,772 results
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