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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1963 1
1964 5
1965 67
1966 80
1967 85
1968 84
1969 102
1970 88
1971 115
1972 96
1973 103
1974 115
1975 103
1976 93
1977 97
1978 91
1979 135
1980 95
1981 118
1982 162
1983 128
1984 159
1985 202
1986 189
1987 199
1988 196
1989 215
1990 219
1991 211
1992 208
1993 281
1994 262
1995 310
1996 278
1997 293
1998 290
1999 307
2000 285
2001 300
2002 384
2003 371
2004 419
2005 459
2006 373
2007 383
2008 417
2009 377
2010 440
2011 492
2012 454
2013 534
2014 537
2015 416
2016 409
2017 409
2018 341
2019 181
2020 8
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13,043 results
Results by year
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Page 1
Liver abnormalities and endocrine diseases.
Burra P. Best Pract Res Clin Gastroenterol 2013 - Review. PMID 24090942
Liver diseases such as hepatitis, hepatocellular carcinoma, and cirrhosis may cause altered levels of thyroid hormones, and alcoholic liver disease, both due to the noxious substance ethanol as well as to the hepatic damage it causes, may be responsible for altered thyroid function. ...Chronic liver disease, on the other hand, has profound repercussions on sex hormone metabolism, inducing feminization in men and infertility and amenorrhoea in women. ...
Liver diseases such as hepatitis, hepatocellular carcinoma, and cirrhosis may cause altered levels of thyroid hormones, and al
Pathophysiology of portal hypertension
Iwakiri Y. Clin Liver Dis 2014 - Review. PMID 24679494 Free PMC article.
Portal hypertension is a major complication of liver disease that results from a variety of pathologic conditions that increase the resistance to the portal blood flow into the liver. ...This article summarizes the factors that increase (1) intrahepatic vascular resistance and (2) the blood flow in the splanchnic and systemic circulations in liver cirrhosis. ...
Portal hypertension is a major complication of liver disease that results from a variety of pathologic conditions that increas …
Pathophysiology of Non Alcoholic Fatty Liver Disease.
Petta S, et al. Int J Mol Sci 2016 - Review. PMID 27973438 Free PMC article.
The physiopathology of fatty liver and metabolic syndrome are influenced by diet, life style and inflammation, which have a major impact on the severity of the clinicopathologic outcome of non-alcoholic fatty liver disease. A short comprehensive review is provided on current knowledge of the pathophysiological interplay among major circulating effectors/mediators of fatty liver, such as circulating lipids, mediators released by adipose, muscle and liver tissues and pancreatic and gut hormones in relation to diet, exercise and inflammation....
The physiopathology of fatty liver and metabolic syndrome are influenced by diet, life style and inflammation, which have a major imp …
Nonalcoholic Fatty Liver Disease: Pathogenesis and Disease Spectrum.
Hardy T, et al. Annu Rev Pathol 2016 - Review. PMID 26980160
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of liver dysfunction in the Western world and is increasing owing to its close association with obesity and insulin resistance. NAFLD represents a spectrum of liver disease that, in a minority of patients, can lead to progressive nonalcoholic steatohepatitis (NASH), fibrosis, and ultimately hepatocellular carcinoma and liver failure. ...
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of liver dysfunction in the Western world and is incr …
Pathophysiology of Liver Fibrosis.
Pinzani M. Dig Dis 2015. PMID 26159264
Progressive accumulation of fibrillar extracellular matrix (ECM) in the liver is the consequence of reiterated liver tissue damage due to infective (mostly hepatitis B and C viruses), toxic/drug-induced, metabolic and autoimmune causes, and the relative chronic activation of the wound-healing reaction. ...The mechanisms responsible for the fibrogenic evolution of chronic liver diseases can be summarized in three main groups: chronic activation of the wound-healing reaction, oxidative stress-related molecular mechanisms, and the derangement of the so-called 'epithelial-mesenchymal' interaction leading to the generation of reactive cholangiocytes and peribiliary fibrosis. ...
Progressive accumulation of fibrillar extracellular matrix (ECM) in the liver is the consequence of reiterated liver tissue da …
Modulation of hepatic steatosis by dietary fatty acids
Ferramosca A and Zara V. World J Gastroenterol 2014 - Review. PMID 24587652 Free PMC article.
Non-alcoholic fatty liver disease (NAFLD) describes a range of conditions caused by fat deposition within liver cells. Liver fat content reflects the equilibrium between several metabolic pathways involved in triglyceride synthesis and disposal, such as lipolysis in adipose tissue and de novo lipogenesis, triglyceride esterification, fatty acid oxidation and very-low-density lipoprotein synthesis/secretion in hepatic tissue. ...It is noteworthy that both quantitative and qualitative aspects of dietary fat influence triglyceride deposition in the liver. ...
Non-alcoholic fatty liver disease (NAFLD) describes a range of conditions caused by fat deposition within liver cells. …
Cell death mechanisms in human chronic liver diseases: a far cry from clinical applicability.
Mazzolini G, et al. Clin Sci (Lond) 2016 - Review. PMID 27798227
Various aetiologies probably induce different predominant cell death modes within the liver, although the death modes involved may change during disease progression. ...Still the serum-derived markers are valuable tools to assess severity of chronic liver diseases. This review gives a short overview of known hepatocellular cell death modes in various aetiologies of chronic liver disease. ...
Various aetiologies probably induce different predominant cell death modes within the liver, although the death modes involved may ch …
Pathophysiology of Alpha-1 Antitrypsin Deficiency Liver Disease.
Teckman JH and Blomenkamp KS. Methods Mol Biol 2017. PMID 28752441
Classical alpha-1 antitrypsin (a1AT) deficiency is an autosomal recessive disease associated with an increased risk of liver disease in adults and children, and with lung disease in adults (Teckman and Jain, Curr Gastroenterol Rep 16(1):367, 2014). The vast majority of the liver disease is associated with homozygosity for the Z mutant allele, the so-called PIZZ. These homozygous individuals synthesize large quantities of a1AT mutant Z protein in the liver, but the mutant protein folds improperly during biogenesis and approximately 85% of the molecules are retained within the hepatocytes rather than appropriately secreted. ...
Classical alpha-1 antitrypsin (a1AT) deficiency is an autosomal recessive disease associated with an increased risk of liver
Nonalcoholic fatty liver disease: from steatosis to cirrhosis.
Farrell GC and Larter CZ. Hepatology 2006 - Review. PMID 16447287
Age, activity of steatohepatitis, and established fibrosis predispose to cirrhosis, which has a 7- to 10-year liver-related mortality of 12% to 25%. ...The same potential for "unwinding" fibrotic NASH is indicated by studies of the peroxisome proliferation activator receptor (PPAR)-gamma agonist "glitazones," but these agents may improve liver disease at the expense of worsening obesity. ...
Age, activity of steatohepatitis, and established fibrosis predispose to cirrhosis, which has a 7- to 10-year liver-related mortality …
13,043 results
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