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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1952 1
1953 1
1954 2
1955 4
1956 4
1957 15
1958 17
1959 14
1960 17
1961 23
1962 18
1963 1
1964 3
1965 76
1966 124
1967 200
1968 267
1969 247
1970 315
1971 348
1972 396
1973 386
1974 422
1975 460
1976 462
1977 431
1978 456
1979 649
1980 703
1981 717
1982 767
1983 922
1984 1003
1985 1045
1986 1066
1987 1057
1988 1058
1989 1192
1990 1291
1991 1297
1992 1229
1993 1299
1994 1353
1995 1423
1996 1443
1997 1400
1998 1542
1999 1605
2000 1671
2001 1763
2002 1747
2003 1943
2004 1986
2005 2159
2006 2288
2007 2343
2008 2580
2009 2601
2010 2845
2011 3102
2012 3429
2013 3706
2014 3862
2015 4051
2016 3689
2017 3597
2018 3504
2019 1887
2020 50
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Search Results

78,140 results
Results by year
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Page 1
Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma
Cancer Genome Atlas Research Network. Electronic address: wheeler@bcm.edu and Cancer Genome Atlas Research Network . Cell 2017. PMID 28622513 Free PMC article.
Liver cancer has the second highest worldwide cancer mortality rate and has limited therapeutic options. We analyzed 363 hepatocellular carcinoma (HCC) cases by whole-exome sequencing and DNA copy number analyses, and we analyzed 196 HCC cases by DNA methylation, RNA, miRNA, and proteomic expression also. ...
Liver cancer has the second highest worldwide cancer mortality rate and has limited therapeutic options. We analyzed 363 hepatocellul
Animal models of non-alcoholic fatty liver disease: current perspectives and recent advances.
Lau JK, et al. J Pathol 2017 - Review. PMID 27757953 Free PMC article.
Non-alcoholic fatty liver disease (NAFLD) is a continuous spectrum of diseases characterized by excessive lipid accumulation in hepatocytes. NAFLD progresses from simple liver steatosis to non-alcoholic steatohepatitis and, in more severe cases, to liver fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). ...
Non-alcoholic fatty liver disease (NAFLD) is a continuous spectrum of diseases characterized by excessive lipid accumulation in hepat …
Hepatocellular carcinoma pathogenesis: from genes to environment
Farazi PA and DePinho RA. Nat Rev Cancer 2006 - Review. PMID 16929323
This Review summarizes the current state of knowledge of this, the most common and dreaded liver neoplasm, and highlights the principal challenges and scientific opportunities that are relevant to controlling this accelerating global health crisis....
This Review summarizes the current state of knowledge of this, the most common and dreaded liver neoplasm, and highlights the …
Mutational signatures reveal the dynamic interplay of risk factors and cellular processes during liver tumorigenesis.
Letouzé E, et al. Nat Commun 2017. PMID 29101368 Free PMC article.
With a diversity of risk factors, liver cancer is an ideal model to study these interactions. Here, we analyze the whole genomes of 44 new and 264 published liver cancers and we identify 10 mutational and 6 structural rearrangement signatures showing distinct relationships with environmental exposures, replication, transcription, and driver genes. ...These findings shed new light on the natural history of liver cancers....
With a diversity of risk factors, liver cancer is an ideal model to study these interactions. Here, we analyze the whole genomes of 4 …
IL-6 trans-signaling is essential for the development of hepatocellular carcinoma in mice
Bergmann J, et al. Hepatology 2017. PMID 27770462
Whereas IL-6 classic signaling is important for innate and acquired immunity, IL-6 trans-signaling has been linked to accelerated liver regeneration and several chronic inflammatory pathologies. However, its implication in liver tumorigenesis has not been addressed yet. Here, we show that IL-6 trans-signaling, but not IL-6 classic signaling, is essential to promote hepatocellular carcinogenesis by two mechanisms: First, it prevents DNA-damage-induced hepatocyte apoptosis through suppression of p53 and enhances β-catenin activation and tumor proliferation. ...
Whereas IL-6 classic signaling is important for innate and acquired immunity, IL-6 trans-signaling has been linked to accelerated liver
Identification of chromatin-accessible domains in non-alcoholic steatohepatitis-derived hepatocellular carcinoma
Dechassa ML, et al. Mol Carcinog 2018. PMID 29603380
Non-alcoholic steatohepatitis (NASH) is becoming one of the major causes of hepatocellular carcinoma (HCC) in the United States and Western countries; however, the molecular mechanisms associated with NASH-related liver carcinogenesis are not well understood. ...
Non-alcoholic steatohepatitis (NASH) is becoming one of the major causes of hepatocellular carcinoma (HCC) in the United States and Western …
Overview of the molecular biology of hepatocellular neoplasms and hepatoblastomas of the mouse liver.
Kim Y, et al. Toxicol Pathol 2005 - Review. PMID 15805069
The molecular pathogenesis of chemically induced hepatocellular neoplasms and hepatoblastomas in the B6C3FI mouse is unclear but may involve alterations in the fi-catenin/Wnt signaling pathway as was recently described for human liver neoplasms. ...Cyclin D1 may provide an advantage during tumor progression of hepatocellular neoplasms and hepatoblastomas. The review will also focus on other genes which are important in mouse and human liver tumors....
The molecular pathogenesis of chemically induced hepatocellular neoplasms and hepatoblastomas in the B6C3FI mouse is unclear but may …
78,140 results
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