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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 2
1947 6
1948 11
1949 5
1950 7
1951 8
1952 6
1953 9
1954 11
1955 15
1956 15
1957 13
1958 17
1959 17
1960 12
1961 15
1962 27
1963 110
1964 166
1965 107
1966 114
1967 117
1968 124
1969 115
1970 95
1971 118
1972 113
1973 113
1974 127
1975 125
1976 112
1977 133
1978 124
1979 120
1980 133
1981 103
1982 96
1983 102
1984 87
1985 116
1986 101
1987 95
1988 98
1989 122
1990 118
1991 153
1992 150
1993 150
1994 123
1995 144
1996 124
1997 113
1998 137
1999 117
2000 116
2001 106
2002 137
2003 143
2004 152
2005 170
2006 187
2007 188
2008 202
2009 185
2010 203
2011 212
2012 238
2013 242
2014 268
2015 246
2016 237
2017 202
2018 201
2019 72
2020 1
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7,933 results
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Liver regeneration.
Mao SA, et al. Transl Res 2014 - Review. PMID 24495569 Free PMC article.
Increased understanding of the regenerative process has significant benefit in the treatment of liver failure. Furthermore, understanding of liver regeneration may shed light on the development of cancer within the cirrhotic liver. This review provides an overview of the models of study currently used in liver regeneration, the molecular basis of liver regeneration, and the role of liver progenitor cells in regeneration of the liver. ...
Increased understanding of the regenerative process has significant benefit in the treatment of liver failure. Furthermore, un …
Liver regeneration - mechanisms and models to clinical application.
Forbes SJ and Newsome PN. Nat Rev Gastroenterol Hepatol 2016 - Review. PMID 27353402
Liver regeneration has been studied for many decades and the mechanisms underlying regeneration of the normal liver following resection or moderate damage are well described. ...Fatty liver disease, chronic scarring, prior chemotherapy and massive liver injury can all inhibit the normal programme of regeneration and can lead to liver failure. ...
Liver regeneration has been studied for many decades and the mechanisms underlying regeneration of the normal liver
Liver Regeneration: Analysis of the Main Relevant Signaling Molecules.
Tao Y, et al. Mediators Inflamm 2017 - Review. PMID 28947857 Free PMC article.
Liver regeneration is a highly organized tissue regrowth process and is the most important reaction of the liver to injury. The overall process of liver regeneration includes three phases: priming stage, proliferative phase, and termination phase. ...While during the termination stage, hepatocytes will discontinue to proliferate to maintain normal liver mass and function. Except for cytokine- and growth factor-mediated pathways involved in regulating liver regeneration, new substances and technologies emerge to influence the regenerative process. ...
Liver regeneration is a highly organized tissue regrowth process and is the most important reaction of the liver to inj
Liver regeneration.
Fausto N, et al. Hepatology 2006 - Review. PMID 16447274
During liver regeneration after partial hepatectomy, normally quiescent hepatocytes undergo one or two rounds of replication to restore the liver mass by a process of compensatory hyperplasia. ...Thus, loss of function from a single gene rarely leads to complete blockage of liver regeneration. The innate immune system plays an important role in the initiation of liver regeneration after partial hepatectomy, and new cytokines and receptors that participate in initiation mechanisms have been identified. ...
During liver regeneration after partial hepatectomy, normally quiescent hepatocytes undergo one or two rounds of replication t …
Liver regeneration in aged mice: new insights.
Pibiri M. Aging (Albany NY) 2018 - Review. PMID 30157472 Free PMC article.
Extra-cellular factors, such as age-dependent changes in hepatic stellate cells affect liver regeneration through inhibition of progenitor cells and reduction of liver perfusion. ...Accordingly, young plasma restores liver regeneration in aged animals through autophagy re-establishment. This review will discuss how intracellular and extracellular factors cooperate to guarantee a proper liver regeneration and the possible causes of its impairment during aging. ...
Extra-cellular factors, such as age-dependent changes in hepatic stellate cells affect liver regeneration through inhibition o …
Liver regeneration.
Michalopoulos GK and DeFrances MC. Science 1997 - Review. PMID 9082986
Liver regeneration after the loss of hepatic tissue is a fundamental parameter of liver response to injury. Recognized as a phenomenon from mythological times, it is now defined as an orchestrated response induced by specific external stimuli and involving sequential changes in gene expression, growth factor production, and morphologic structure. ...
Liver regeneration after the loss of hepatic tissue is a fundamental parameter of liver response to injury. Recognized
Immune cells in liver regeneration.
Li N and Hua J. Oncotarget 2017 - Review. PMID 27690296 Free PMC article.
After partial hepatectomy, hepatocytes proliferate to restore mass and function of the liver. Macrophages, natural killer (NK) cells, natural killer T (NKT) cells, dendritic cells (DC), eosinophils, gamma delta T (γδT) cells, and conventional T cells, as well as other subsets of the immune cells residing in the liver control liver regeneration, either through direct interactions with hepatocytes or indirectly by releasing inflammatory cytokines. Here, we review recent progress regarding the immune cells in the liver and their functions during liver regeneration....
After partial hepatectomy, hepatocytes proliferate to restore mass and function of the liver. Macrophages, natural killer (NK) cells, …
Liver regeneration.
Michalopoulos GK. J Cell Physiol 2007 - Review. PMID 17559071 Free PMC article.
Liver regeneration after partial hepatectomy is a very complex and well-orchestrated phenomenon. It is carried out by the participation of all mature liver cell types. ...Liver manages to restore any lost mass and adjust its size to that of the organism, while at the same time providing full support for body homeostasis during the entire regenerative process. ...
Liver regeneration after partial hepatectomy is a very complex and well-orchestrated phenomenon. It is carried out by the part
Human Liver Regeneration: An Etiology Dependent Process.
Van Haele M, et al. Int J Mol Sci 2019 - Review. PMID 31083462 Free PMC article.
Hepatocytes, cholangiocytes, liver progenitor cells, and peribiliary glands have proven to be compartments of regeneration. The ductular reaction is a common denominator in virtually all liver diseases; however, it is predominantly found in late-stage hepatic and biliary diseases. ...In this manuscript, we focus on the etiology-specific damage that is observed in different human diseases and how the liver regulates the regenerative response in an acute and chronic setting. ...
Hepatocytes, cholangiocytes, liver progenitor cells, and peribiliary glands have proven to be compartments of regeneration. Th …
Advances in liver regeneration.
Michalopoulos GK. Expert Rev Gastroenterol Hepatol 2014 - Review. PMID 24964729
Liver regeneration after partial hepatectomy is the only example of a regenerative process in mammals in which the organ/body weight ratio returns to 100% of the original when the process is complete. The adjustment of liver weight to the needs of the body suggests a complicated set of control points, a 'hepatostat'. There has been much progress in elucidation of mechanisms involved in initiation of liver regeneration. ...
Liver regeneration after partial hepatectomy is the only example of a regenerative process in mammals in which the orga
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