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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1998 6
1999 11
2000 23
2001 30
2002 37
2003 30
2004 37
2005 29
2006 33
2007 33
2008 31
2009 38
2010 52
2011 57
2012 69
2013 72
2014 67
2015 45
2016 49
2017 43
2018 61
2019 28
2020 2
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804 results
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Transposable elements in cancer
Burns KH. Nat Rev Cancer 2017 - Review. PMID 28642606
Transposable elements give rise to interspersed repeats, sequences that comprise most of our genomes. These mobile DNAs have been historically underappreciated - both because they have been presumed to be unimportant, and because their high copy number and variability pose unique technical challenges. ...Interest in the human mobilome has never been greater, and methods enabling its study are maturing at a fast pace. This Review describes the activity of transposable elements in human cancers, particularly long interspersed element-1 (LINE-1). ...
Transposable elements give rise to interspersed repeats, sequences that comprise most of our genomes. These mobile DNAs have been his …
Long interspersed nucleotide element-1 (LINE-1) methylation in colorectal cancer.
Kerachian MA and Kerachian M. Clin Chim Acta 2019 - Review. PMID 30445031
Long interspersed nuclear elements (LINEs) are a form of retrotransposable element found in many eukaryotic genomes. These LINEs, when active, can mobilize in the cell and steadily cause genomic rearrangement. ...
Long interspersed nuclear elements (LINEs) are a form of retrotransposable element found in many eukaryotic genomes. These LIN
Selective silencing of euchromatic L1s revealed by genome-wide screens for L1 regulators
Liu N, et al. Nature 2018. PMID 29211708 Free PMC article.
Long interspersed element-1 (LINE-1, also known as L1), the only currently autonomous mobile transposon in humans, occupies 17% of the genome and generates inter- and intra-individual genetic variation, in some cases resulting in disease. ...
Long interspersed element-1 (LINE-1, also known as L1), the only currently autonomous mobile transposon in humans, occupies 17
Detection of aneuploidy in patients with cancer through amplification of long interspersed nucleotide elements (LINEs).
Douville C, et al. Proc Natl Acad Sci U S A 2018. PMID 29432176 Free PMC article.
We previously described primers that could be used to amplify ∼38,000 unique long interspersed nucleotide elements (LINEs) from throughout the genome. ...
We previously described primers that could be used to amplify ∼38,000 unique long interspersed nucleotide elements (LINEs) fro …
Retrotransposons as regulators of gene expression
Elbarbary RA, et al. Science 2016 - Review. PMID 26912865 Free PMC article.
We focus on two types of TEs: long interspersed elements (LINEs) and short interspersed elements (SINEs). LINEs and SINEs are retrotransposons; that is, they transpose via an RNA intermediate. ...
We focus on two types of TEs: long interspersed elements (LINEs) and short interspersed elements (SINEs). LINEs and SIN …
The DNA methylation landscape of human early embryos
Guo H, et al. Nature 2014. PMID 25079557
Finally, we also show that long interspersed nuclear elements or short interspersed nuclear elements that are evolutionarily young are demethylated to a milder extent compared to older elements in the same family and have higher abundance of transcripts, indicating that early embryos tend to retain higher residual methylation at the evolutionarily younger and more active transposable elements. ...
Finally, we also show that long interspersed nuclear elements or short interspersed nuclear elements that are evolution …
LINE-1 activity and regulation in cancer
Rodic N. Front Biosci (Landmark Ed) 2018 - Review. PMID 29293456
LINE-1 retrotransposons are ubiquitous genetic elements interspersed within the primary nuclear genome of modern day humans. ...Second, I discuss three genetic pathways - epigenetic regulation, interferon signaling, and genome integrity - as they relate to LINE-1 regulation in cancer. ...
LINE-1 retrotransposons are ubiquitous genetic elements interspersed within the primary nuclear genome of modern day humans. ...Secon …
Repression of Stress-Induced LINE-1 Expression Protects Cancer Cell Subpopulations from Lethal Drug Exposure
Guler GD, et al. Cancer Cell 2017. PMID 28781121 Free article.
We also show that survival of DTPs is, in part, maintained by regulators of H3K9me3-mediated heterochromatin formation and that the observed increase in H3K9me3 in DTPs is most prominent over long interspersed repeat element 1 (LINE-1). ...
We also show that survival of DTPs is, in part, maintained by regulators of H3K9me3-mediated heterochromatin formation and that the observed …
Genomic mosaicism in the developing and adult brain
Rohrback S, et al. Dev Neurobiol 2018 - Review. PMID 30027562 Free PMC article.
GM forms include aneuploidies and aneusomies, smaller copy number variations (CNVs), long interspersed nuclear element type 1 (LINE1) repeat elements, and single nucleotide variations (SNVs), as well as DNA content variation (DCV) that reflects all forms of GM with greatest coverage of large, brain cell populations. ...
GM forms include aneuploidies and aneusomies, smaller copy number variations (CNVs), long interspersed nuclear element type 1 …
Retrotransposable genetic elements causing neutrophil defects
Roos D and de Boer M. Eur J Clin Invest 2018 - Review. PMID 29774526
In humans, the only autonomous retrotransposable elements are members of the Long INterspersed Element-1 (LINE-1) family. LINE-1s may cause gene inactivation and human disease. ...
In humans, the only autonomous retrotransposable elements are members of the Long INterspersed Element-1 (LINE-1) family. LINE …
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