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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1999 3
2000 2
2001 5
2002 6
2003 9
2004 16
2005 16
2006 18
2007 29
2008 36
2009 28
2010 44
2011 50
2012 47
2013 67
2014 56
2015 50
2016 41
2017 43
2018 49
2019 18
2020 0
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568 results
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Page 1
Low-density lipoprotein receptor-related protein 6 regulates alternative pre-mRNA splicing.
Yuan T, et al. J Cell Mol Med 2018. PMID 30070011 Free PMC article.
Low-density lipoprotein receptor-related protein 6 (LRP6) serves as a Wnt coreceptor. Although Wnt/LRP6 signalling is best known for the β-catenin-dependent regulation of target genes in tissue development and homeostasis, emerging evidence demonstrates the biological aspects of LRP6 beyond a Wnt coreceptor. ...The interaction of LRP6 with the adenine-rich sequence was sufficient to overcome AED exclusion by a splicing repressor, polypyrimidine tract binding protein-1. ...
Low-density lipoprotein receptor-related protein 6 (LRP6) serves as a Wnt coreceptor. Altho
Cardiomyocyte-Restricted Low Density Lipoprotein Receptor-Related Protein 6 (LRP6) Deletion Leads to Lethal Dilated Cardiomyopathy Partly Through Drp1 Signaling.
Chen Z, et al. Theranostics 2018. PMID 29344294 Free PMC article.
Low density lipoprotein receptor-related protein 6 (LRP6), a wnt co-receptor, regulates multiple functions in various organs. ...Further analysis revealed cardiac LRP6 deletion suppressed autophagic degradation and fatty acid utilization, coinciding with activation of dynamin-related protein 1 (Drp1) and downregulation of nuclear TFEB (Transcription factor EB). ...
Low density lipoprotein receptor-related protein 6 (LRP6), a wnt co-receptor, regula
Low-Density Lipoprotein Receptor-Related Protein 6 Is Essential for Trophoblast Survival and Invasion.
Li L, et al. Reprod Sci 2019. PMID 29439617
Low-density lipoprotein receptor-related protein 6 (LRP6) is implicated in angiogenesis and several vascular diseases, but its function in trophoblast regulation is still not fully understood. ...Lipoprotein receptor-related protein 6 might positively regulate the remodeling of the maternal artery through both endovascular formation and trophoblast invasion....
Low-density lipoprotein receptor-related protein 6 (LRP6) is implicated in angiogenesis and
Phosphorylation of low density lipoprotein receptor-related protein 6 is involved in receptor for advanced glycation end product-mediated β-catenin stabilization in a toluene diisocyanate-induced asthma model.
Xiong J, et al. Int Immunopharmacol 2018. PMID 29656209
BACKGROUND: We have previously demonstrated that the receptor for advanced glycation end products (RAGE)/β-catenin axis plays a vital role in regulating airway inflammation and airway remodeling in a toluene diisocyanate (TDI)-induced murine asthma model. ...Given that phosphorylation of the low-density lipoprotein receptor-related protein 6 (Lrp6) is a key step in mediating β-catenin stabilization in canonical wnt/β-catenin signaling, we explored the possible relationship between RAGE and Lrp6 in regulating β-catenin stabilization in TDI-induced asthma. ...
BACKGROUND: We have previously demonstrated that the receptor for advanced glycation end products (RAGE)/β-catenin axis plays a vital …
Downregulated low-density lipoprotein receptor-related protein 6 induces the maldevelopment of extravillous trophoblast via Wnt/β-catenin signaling pathway.
Yu X, et al. Mol Cell Probes 2019. PMID 30684559
Here, we aimed to study the functions of low-density lipoprotein receptor-related protein 6 (LRP6) in PE pathogenesis. A comparative analysis of cellular gene expressions between placenta tissues collected from PE patients and normal pregnant women showed that the expressions of LRP6, β-catenin and matrix metallopeptidases/TIMP metallopeptidase inhibitors (MMPs/TIMPs) ratio in placentas of PE patients were much lower than the normal. ...The mRNA and protein levels of β-catenin, an intracellular signal transducer of Wnt signaling pathway, were significantly up-regulated under the effects of LRP6 overexpression. ...
Here, we aimed to study the functions of low-density lipoprotein receptor-related protein 6
Low-density lipoprotein receptor-related protein 6 is a novel coreceptor of protease-activated receptor-2 in the dynamics of cancer-associated β-catenin stabilization.
Nag JK, et al. Oncotarget 2017. PMID 28418856 Free PMC article.
Novel association of low-density lipoprotein-related protein 6 (LRP6), a known coreceptor of Frizzleds (Fz), with PAR2 takes place following PAR2 activation. ...The association was further supported by ZDOCK protein-protein server. PAR2-LRP6 interaction promotes rapid phosphorylation of LRP6, which results in the recruitment of Axin. ...
Novel association of low-density lipoprotein-related protein 6 (LRP6), a known coreceptor of Frizz …
A novel high-content imaging-based technique for measuring binding of Dickkopf-1 to low-density lipoprotein receptor-related protein 6.
Priestley RS, et al. J Pharmacol Toxicol Methods 2019. PMID 30476623
INTRODUCTION: Dickkopf-related protein 1 (Dkk1) is a secreted protein ligand of low-density lipoprotein receptor-related protein 6 (LRP6), which antagonises canonical Wnt signalling. ...Cell-based Dkk1-LRP6 assays reported in the literature use either modified Dkk1 protein and/or do not possess suitable throughput for drug screening. ...
INTRODUCTION: Dickkopf-related protein 1 (Dkk1) is a secreted protein ligand of low-density lipoprotei
MicroRNA-590-3p inhibits trophoblast-dependent maternal spiral artery remodeling by repressing low-density lipoprotein receptor-related protein 6.
Zhang Y, et al. Mol Genet Genomic Med 2018. PMID 30411539 Free PMC article.
Low-density lipoprotein receptor-related protein 6 (LRP6) and microRNAs (miRNAs, miRs) are suggested to be involved in angiogenesis and several vascular diseases; however, their functions in the control of trophoblast remain elusive. ...
Low-density lipoprotein receptor-related protein 6 (LRP6) and microRNAs (miRNAs, miRs) are
Low-Density Lipoprotein Receptor-Related Protein 6 (LRP6) Is a Novel Nutritional Therapeutic Target for Hyperlipidemia, Non-Alcoholic Fatty Liver Disease, and Atherosclerosis.
Go GW. Nutrients 2015 - Review. PMID 26046396 Free PMC article.
Low-density lipoprotein receptor-related protein 6 (LRP6) is a member of the low-density lipoprotein receptor family and has a unique structure, which facilitates its multiple functions as a co-receptor for Wnt/β-catenin signaling and as a ligand receptor for endocytosis. ...These studies have demonstrated that LRP6 plays a role in LDL receptor-mediated LDL uptake. In addition, when the LRP6 mutant impaired Wnt-LRP6 signaling, hyperlipidemia, non-alcoholic fatty liver disease, and atherosclerosis developed. ...
Low-density lipoprotein receptor-related protein 6 (LRP6) is a member of the low-
Harnessing low-density lipoprotein receptor protein 6 (LRP6) genetic variation and Wnt signaling for innovative diagnostics in complex diseases.
Wang ZM, et al. Pharmacogenomics J 2018 - Review. PMID 28696417
Low-density lipoprotein receptor protein 6 (LRP6) is a Wnt co-receptor with essential functions in the Wnt/β-catenin pathway, and mutations in LRP6 gene are linked to many complex human diseases, including metabolic syndrome, cancer, Alzheimer's disease and osteoporosis. ...
Low-density lipoprotein receptor protein 6 (LRP6) is a Wnt co-receptor with essential funct
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