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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1965 1
1968 1
1974 1
1976 1
1977 1
1978 3
1979 1
1980 4
1981 1
1982 2
1985 6
1986 2
1987 1
1988 1
1989 3
1990 6
1991 4
1992 10
1993 5
1994 10
1995 10
1996 12
1997 8
1998 9
1999 10
2000 8
2001 16
2002 14
2003 14
2004 13
2005 20
2006 14
2007 13
2008 21
2009 12
2010 22
2011 23
2012 18
2013 24
2014 31
2015 31
2016 32
2017 28
2018 25
2019 6
2020 0
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448 results
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Page 1
Cutaneous T-cell Lymphoma.
Pulitzer M. Clin Lab Med 2017 - Review. PMID 28802499 Free PMC article.
Cutaneous T-cell lymphomas comprise a heterogeneous group of diseases characterized by monoclonal proliferations of T lymphocytes primarily involving skin, modified skin appendages, and some mucosal sites. ...Select unusual phenotypes or diagnostic examples of classic phenotypes are demonstrated, and flags for consideration while making a pathologic diagnosis of cutaneous T-cell lymphoma are suggested....
Cutaneous T-cell lymphomas comprise a heterogeneous group of diseases characterized by monoclonal proliferations of T lymphocy
Genomic landscape of cutaneous T cell lymphoma.
Choi J, et al. Nat Genet 2015. PMID 26192916 Free PMC article.
Cutaneous T cell lymphoma (CTCL) is a non-Hodgkin lymphoma of skin-homing T lymphocytes. We performed exome and whole-genome DNA sequencing and RNA sequencing on purified CTCL and matched normal cells. The results implicate mutations in 17 genes in CTCL pathogenesis, including genes involved in T cell activation and apoptosis, NF-κB signaling, chromatin remodeling and DNA damage response. ...
Cutaneous T cell lymphoma (CTCL) is a non-Hodgkin lymphoma of skin-homing T lymphocytes. We performed exome and whole-genome D
The mutational landscape of cutaneous T cell lymphoma and Sézary syndrome.
da Silva Almeida AC, et al. Nat Genet 2015. PMID 26551667 Free PMC article.
Sézary syndrome is a leukemic and aggressive form of cutaneous T cell lymphoma (CTCL) resulting from the malignant transformation of skin-homing central memory CD4(+) T cells. ...Collectively, our findings provide new insights into the genetics of Sézary syndrome and CTCL and support the development of personalized therapies targeting key oncogenically activated signaling pathways for the treatment of these diseases....
Sézary syndrome is a leukemic and aggressive form of cutaneous T cell lymphoma (CTCL) resulting from the malignant transformat …
Genetics of Cutaneous T Cell Lymphoma: From Bench to Bedside.
Damsky WE and Choi J. Curr Treat Options Oncol 2016 - Review. PMID 27262707
Cutaneous T cell lymphomas (CTCLs) are non-Hodgkin lymphomas of skin homing T cells. Although early-stage disease may be limited to the skin, tumor cells in later stage disease can populate the blood, the lymph nodes, and the visceral organs. ...Collectively, these somatic mutations drive lymphomagenesis via cancer-promoting changes in proliferation, apoptosis, and T cell effector function. ...
Cutaneous T cell lymphomas (CTCLs) are non-Hodgkin lymphomas of skin homing T cells. Although early-stage disease may be limit
Chromatin Accessibility Landscape of Cutaneous T Cell Lymphoma and Dynamic Response to HDAC Inhibitors.
Qu K, et al. Cancer Cell 2017. PMID 28625481 Free PMC article.
Here, we define the landscape and dynamics of active regulatory DNA in cutaneouscell lymphoma (CTCL) by ATAC-seq. Analysis of 111 human CTCL and control samples revealed extensive chromatin signatures that distinguished leukemic, host, and normal CD4(+) T cells. ...
Here, we define the landscape and dynamics of active regulatory DNA in cutaneouscell lymphoma (CTCL) by ATAC-seq. Analysis …
Molecular advances in cutaneous T-cell lymphoma.
Bastidas Torres AN, et al. Semin Cutan Med Surg 2018 - Review. PMID 29719024
Cutaneous T-cell lymphoma (CTCL) is a group of malignancies derived from skin-homing T cells. Mycosis fungoides (MF) and Sézary syndrome (SS) are the most common CTCL variants. ...These studies have revealed that genes subjected to oncogenic mutations take part in cell cycle regulation, chromatin modification, Janus kinase (JAK)-signal transducer and activator of transcription protein (STAT) signaling, T-cell receptor (TCR)/ nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling, and microtubule associated protein kinase (MAPK) signaling, which suggests that deregulation of these cellular processes underlies lymphomagenesis. ...
Cutaneous T-cell lymphoma (CTCL) is a group of malignancies derived from skin-homing T cells. Mycosis fungoides (MF) and Sézar
Cutaneous T-Cell Lymphoma, a Novel Manifestation of PDGFRA-Rearranged Neoplasm.
Behdad A, et al. Am J Dermatopathol 2018. PMID 29505472
However, mature T-cell lymphoma has not been previously associated with PDGFRA aberrations. We report a patient who presented with simultaneous T-lymphoblastic lymphoma, focal myeloid proliferation, and cutaneous cytotoxic T-cell lymphoma refractory to chemotherapy. ...We report the first case of a mature cutaneous T-cell lymphoma with PDGFRA rearrangement, expanding the spectrum of neoplasms associated with this genetic abnormality. ...
However, mature T-cell lymphoma has not been previously associated with PDGFRA aberrations. We report a patient who presented with si …
Diminished microRNA-29b level is associated with BRD4-mediated activation of oncogenes in cutaneous T-cell lymphoma.
Kohnken R, et al. Blood 2018. PMID 29180399 Free PMC article.
MicroRNA (miRNA) dysregulation is a hallmark of cutaneous T-cell lymphoma (CTCL), an often-fatal malignancy of skin-homing CD4(+) T cells for which there are few effective therapies. ...
MicroRNA (miRNA) dysregulation is a hallmark of cutaneous T-cell lymphoma (CTCL), an often-fatal malignancy of skin-homing CD4 …
Inactivation of RUNX3/p46 Promotes Cutaneous T-Cell Lymphoma.
Haider A, et al. J Invest Dermatol 2016. PMID 27377697 Free article.
Here, we show that alterations of RUNX3 by either heterozygous deletion or methylation of its distal promoter can be observed in the tumor cells of 15 of 21 (71%) patients suffering from Sézary syndrome, an aggressive variant of cutaneous T-cell lymphoma. ...Re-expression of RUNX3/p46 reduces cell viability and promotes apoptosis in a RUNX3/p46(low) cell line of cutaneous T-cell lymphoma. ...
Here, we show that alterations of RUNX3 by either heterozygous deletion or methylation of its distal promoter can be observed in the tumor c …
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