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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1953 1
1957 1
1965 1
1966 4
1967 2
1968 1
1969 5
1970 1
1971 3
1972 2
1973 4
1974 3
1975 7
1976 4
1977 5
1978 10
1979 26
1980 13
1981 18
1982 4
1983 12
1984 14
1985 10
1986 4
1987 3
1988 1
1989 7
1990 12
1991 14
1992 15
1993 13
1994 14
1995 14
1996 15
1997 20
1998 13
1999 30
2000 33
2001 33
2002 32
2003 25
2004 18
2005 31
2006 33
2007 37
2008 40
2009 54
2010 61
2011 50
2012 73
2013 66
2014 68
2015 63
2016 62
2017 58
2018 65
2019 28
2020 0
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1,136 results
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Page 1
Genomic landscape of cutaneous T cell lymphoma.
Choi J, et al. Nat Genet 2015. PMID 26192916 Free PMC article.
Cutaneous T cell lymphoma (CTCL) is a non-Hodgkin lymphoma of skin-homing T lymphocytes. We performed exome and whole-genome DNA sequencing and RNA sequencing on purified CTCL and matched normal cells. The results implicate mutations in 17 genes in CTCL pathogenesis, including genes involved in T cell activation and apoptosis, NF-κB signaling, chromatin remodeling and DNA damage response. ...
Cutaneous T cell lymphoma (CTCL) is a non-Hodgkin lymphoma of skin-homing T lymphocytes. We performed exome and whole-genome D
The mutational landscape of cutaneous T cell lymphoma and Sézary syndrome.
da Silva Almeida AC, et al. Nat Genet 2015. PMID 26551667 Free PMC article.
Sézary syndrome is a leukemic and aggressive form of cutaneous T cell lymphoma (CTCL) resulting from the malignant transformation of skin-homing central memory CD4(+) T cells. ...Mutation analysis identified a broad spectrum of somatic mutations in key genes involved in epigenetic regulation (TET2, CREBBP, KMT2D (MLL2), KMT2C (MLL3), BRD9, SMARCA4 and CHD3) and signaling, including MAPK1, BRAF, CARD11 and PRKG1 mutations driving increased MAPK, NF-κB and NFAT activity upon T cell receptor stimulation. ...
Sézary syndrome is a leukemic and aggressive form of cutaneous T cell lymphoma (CTCL) resulting from the malignant transformat …
STAT5 induces miR-21 expression in cutaneous T cell lymphoma.
Lindahl LM, et al. Oncotarget 2016. PMID 27329723 Free PMC article.
In cutaneous T cell lymphomas (CTCL), miR-21 is aberrantly expressed in skin and peripheral blood and displays anti-apoptotic properties in malignant T cells. ...Cytokine starvation ex vivo triggered a decrease in miR-21 expression, whereas IL-2 induced an increased miR-21 expression in primary SS T cells and cultured cytokine-dependent SS cells (SeAx). siRNA-mediated depletion of STAT5 inhibited constitutive- and IL-2-induced miR-21 expression in cytokine-independent and dependent T cell lines, respectively. ...
In cutaneous T cell lymphomas (CTCL), miR-21 is aberrantly expressed in skin and peripheral blood and displays anti-apoptotic …
Inactivation of RUNX3/p46 Promotes Cutaneous T-Cell Lymphoma.
Haider A, et al. J Invest Dermatol 2016. PMID 27377697 Free article.
Here, we show that alterations of RUNX3 by either heterozygous deletion or methylation of its distal promoter can be observed in the tumor cells of 15 of 21 (71%) patients suffering from Sézary syndrome, an aggressive variant of cutaneous T-cell lymphoma. ...Re-expression of RUNX3/p46 reduces cell viability and promotes apoptosis in a RUNX3/p46(low) cell line of cutaneous T-cell lymphoma. ...
Here, we show that alterations of RUNX3 by either heterozygous deletion or methylation of its distal promoter can be observed in the tumor c …
Cutaneous T-cell Lymphoma and Pruritus: The Expression of IL-31 and its Receptors in the Skin.
Nattkemper LA, et al. Acta Derm Venereol 2016. PMID 27001482 Free article.
Approximately 88% of cutaneous T-cell lymphoma (CTCL) patients are affected by pruritus that responds poorly to current antipruritic therapies. ...
Approximately 88% of cutaneous T-cell lymphoma (CTCL) patients are affected by pruritus that responds poorly to current antipr …
Proteomic Approaches to Biomarker Discovery in Cutaneous T-Cell Lymphoma.
Ion A, et al. Dis Markers 2016 - Review. PMID 27821903 Free PMC article.
Cutaneous T-cell lymphoma (CTCL) is the most frequently encountered type of skin lymphoma in humans. CTCL encompasses multiple variants, but the most common types are mycosis fungoides (MF) and Sezary syndrome (SS). ...Although multiple biomarkers linked to CTCL have been known for a relatively long time (e.g., CD25, CD45, CD45RA, and CD45R0), compared to other cancers (lymphoma, melanoma, colon carcinoma, head and neck cancer, renal cancer, and cutaneous B-cell lymphoma), information about the antigenicity of CTCL remains relatively limited and no dependable protein marker for CTCL has been discovered. ...
Cutaneous T-cell lymphoma (CTCL) is the most frequently encountered type of skin lymphoma in humans. CTCL encompasses multiple
Serum metabolite profiling of cutaneous T-cell lymphoma based on a multiplatform approach.
Jiang G, et al. J Chromatogr B Analyt Technol Biomed Life Sci 2018. PMID 29413580
Cutaneous T-cell lymphoma (CTCL) is a class of non-Hodgkin lymphoma with a difficult early diagnosis. The overall annual age-adjusted incidence of CTCL had consistently increased to around 10.2 cases per million persons. ...Glycerophospholipid metabolism, tryptophan metabolism and purine metabolism were highlighted as 3 major altered pathways in CTCL serum. ...
Cutaneous T-cell lymphoma (CTCL) is a class of non-Hodgkin lymphoma with a difficult early diagnosis. The overall annual age-a
Cutaneous T-cell lymphoma (CTCL): Current practices in blood assessment and the utility of T-cell receptor (TCR)-Vβ chain restriction.
Gibson JF, et al. J Am Acad Dermatol 2016 - Clinical Trial. PMID 26874819 Free PMC article.
BACKGROUND: Accurate quantification of malignant cells in the peripheral blood of patients with cutaneous T-cell lymphoma is important for early detection, prognosis, and monitoring disease burden. OBJECTIVE: We sought to determine the spectrum of current clinical practices; critically evaluate elements of current International Society for Cutaneous Lymphomas (ISCL) B1 and B2 staging criteria; and assess the potential role of T-cell receptor-Vβ analysis by flow cytometry. ...
BACKGROUND: Accurate quantification of malignant cells in the peripheral blood of patients with cutaneous T-cell lymphoma is i …
Novel phosphorylated TAK1 species with functional impact on NF-κB and β-catenin signaling in human Cutaneous T-cell lymphoma.
Gallardo F, et al. Leukemia 2018. PMID 29511289 Free PMC article.
Cutaneous T-cell lymphomas (CTCLs) represent different subtypes of lymphoproliferative disorders with no curative therapies for the advanced forms of the disease (namely mycosis fungoides and the leukemic variant, Sézary syndrome). ...Inhibition of TAK1 precluded NF-κB and β-catenin signaling and induced apoptosis of CTCL cell lines and primary Sézary syndrome cells both in vitro and in vivo. ...
Cutaneous T-cell lymphomas (CTCLs) represent different subtypes of lymphoproliferative disorders with no curative therapies fo
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