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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1964 3
1965 24
1966 69
1967 114
1968 123
1969 156
1970 148
1971 179
1972 184
1973 170
1974 188
1975 230
1976 240
1977 173
1978 203
1979 221
1980 213
1981 240
1982 222
1983 247
1984 234
1985 244
1986 209
1987 241
1988 259
1989 247
1990 233
1991 228
1992 223
1993 197
1994 197
1995 198
1996 215
1997 191
1998 161
1999 150
2000 158
2001 157
2002 172
2003 142
2004 169
2005 182
2006 202
2007 203
2008 257
2009 263
2010 281
2011 291
2012 328
2013 344
2014 324
2015 388
2016 434
2017 428
2018 416
2019 201
2020 5
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11,550 results
Results by year
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Page 1
Autophagy in the pathogenesis of disease
Levine B and Kroemer G. Cell 2008 - Review. PMID 18191218 Free PMC article.
Lysosomal physiology.
Xu H and Ren D. Annu Rev Physiol 2015 - Review. PMID 25668017 Free PMC article.
Lysosomes are acidic compartments filled with more than 60 different types of hydrolases. They mediate the degradation of extracellular particles from endocytosis and of intracellular components from autophagy. ...Lysosomes also contain more than 50 membrane proteins and are equipped with the machinery to sense nutrient availability, which determines the distribution, number, size, and activity of lysosomes to control the specificity of cargo flux and timing (the initiation and termination) of degradation. ...
Lysosomes are acidic compartments filled with more than 60 different types of hydrolases. They mediate the degradation of extracellul
The Lysosome as a Regulatory Hub
Perera RM and Zoncu R. Annu Rev Cell Dev Biol 2016 - Review. PMID 27501449
Transcriptional programs of increasing complexity control the biogenesis, composition, and abundance of lysosomes and fine-tune their activity to match the evolving needs of the cell. ...
Transcriptional programs of increasing complexity control the biogenesis, composition, and abundance of lysosomes and fine-tune their …
Mechanisms of lysosomal positioning and movement
Cabukusta B and Neefjes J. Traffic 2018 - Review. PMID 29900632 Free PMC article.
Lysosomes are highly dynamic organelles that can move rapidly throughout the cell. They distribute in a rather immobile pool located around the microtubule-organizing center in a "cloud," and a highly dynamic pool in the cell periphery. ...In most of these biological events, the involvement of lysosomes is dependent on their ability to move throughout the cytoplasm, to find and fuse to the correct compartments to receive and deliver substrates for further handling. ...
Lysosomes are highly dynamic organelles that can move rapidly throughout the cell. They distribute in a rather immobile pool located
A gene network regulating lysosomal biogenesis and function
Sardiello M, et al. Science 2009. PMID 19556463 Free article.
Lysosomes are organelles central to degradation and recycling processes in animal cells. Whether lysosomal activity is coordinated to respond to cellular needs remains unclear. ...
Lysosomes are organelles central to degradation and recycling processes in animal cells. Whether lysosomal activity is coordinated to
Mechanisms and functions of lysosome positioning
Pu J, et al. J Cell Sci 2016 - Review. PMID 27799357 Free PMC article.
The involvement of lysosomes in most of these processes is now known to depend on the ability of lysosomes to move throughout the cytoplasm. Here, we review recent findings on the mechanisms that mediate the motility and positioning of lysosomes, and the importance of lysosome dynamics for cell physiology and pathology....
The involvement of lysosomes in most of these processes is now known to depend on the ability of lysosomes to move throughout …
Neuronal lysosomes.
Ferguson SM. Neurosci Lett 2019 - Review. PMID 29626653 Free PMC article.
Lysosomes support diverse cellular functions by acting as sites of macromolecule degradation and nutrient recycling. The degradative abilities of lysosomes are conferred by a lumen that is characterized by an acidic pH and which contains numerous hydrolases that support the breakdown of major cellular macromolecules to yield cellular building blocks (amino acids, nucleic acids, sugars, lipids and metals) that are transported into the cytoplasm for their re-use. ...This review will focus on the roles played by lysosomes in distinct neuronal sub-compartments, the regulation of neuronal lysosome sub-cellular localization and the implications of such neuronal lysosome regulation for both physiology and disease....
Lysosomes support diverse cellular functions by acting as sites of macromolecule degradation and nutrient recycling. The degradative
Lysosomes: fusion and function.
Luzio JP, et al. Nat Rev Mol Cell Biol 2007 - Review. PMID 17637737
Lysosomes are dynamic organelles that receive and degrade macromolecules from the secretory, endocytic, autophagic and phagocytic membrane-trafficking pathways. ...However, the function of lysosomes is not restricted to protein degradation: they also fuse with the plasma membrane during cell injury, as well as having more specialized secretory functions in some cell types....
Lysosomes are dynamic organelles that receive and degrade macromolecules from the secretory, endocytic, autophagic and phagocytic mem
Signals from the lysosome: a control centre for cellular clearance and energy metabolism
Settembre C, et al. Nat Rev Mol Cell Biol 2013 - Review. PMID 23609508 Free PMC article.
For a long time, lysosomes were considered merely to be cellular 'incinerators' involved in the degradation and recycling of cellular waste. ...Furthermore, the essential role of lysosomes in autophagic pathways puts these organelles at the crossroads of several cellular processes, with significant implications for health and disease. ...
For a long time, lysosomes were considered merely to be cellular 'incinerators' involved in the degradation and recycling of cellular …
Targeting the lysosome in cancer
Piao S and Amaravadi RK. Ann N Y Acad Sci 2016 - Review. PMID 26599426 Free PMC article.
Lysosomes are membrane-bound intracellular organelles that receive macromolecules delivered by endocytosis, phagocytosis, and autophagy for degradation and recycling. ...
Lysosomes are membrane-bound intracellular organelles that receive macromolecules delivered by endocytosis, phagocytosis, and autopha
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