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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 3
1946 2
1947 5
1948 2
1950 5
1951 5
1952 4
1953 8
1954 11
1955 9
1956 5
1957 7
1958 5
1959 13
1960 16
1961 24
1962 22
1963 26
1964 57
1965 105
1966 75
1967 138
1968 156
1969 183
1970 225
1971 693
1972 1140
1973 984
1974 974
1975 1059
1976 1165
1977 952
1978 1017
1979 1341
1980 1229
1981 1306
1982 1480
1983 1353
1984 1526
1985 1470
1986 1464
1987 1459
1988 1406
1989 1448
1990 1844
1991 1746
1992 1877
1993 1610
1994 1593
1995 1577
1996 1333
1997 1079
1998 1220
1999 1062
2000 924
2001 1314
2002 1710
2003 1748
2004 1515
2005 1107
2006 814
2007 1297
2008 944
2009 970
2010 799
2011 974
2012 1060
2013 748
2014 463
2015 445
2016 416
2017 406
2018 399
2019 177
2020 4
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56,646 results
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Page 1
Who's In and Who's Out-Compositional Control of Biomolecular Condensates
Ditlev JA, et al. J Mol Biol 2018 - Review. PMID 30099028 Free PMC article.
Many condensates behave as dynamic liquids and appear to form through liquid-liquid phase separation driven by weak, multivalent interactions between macromolecules. ...
Many condensates behave as dynamic liquids and appear to form through liquid-liquid phase separation driven by weak, multivalent interaction …
Cryo-EM in drug discovery: achievements, limitations and prospects
Renaud JP, et al. Nat Rev Drug Discov 2018 - Review. PMID 29880918
Cryo-electron microscopy (cryo-EM) of non-crystalline single particles is a biophysical technique that can be used to determine the structure of biological macromolecules and assemblies. ...However, recent technological advances - including the development of direct electron detectors and more effective computational image analysis techniques - are revolutionizing the utility of cryo-EM, leading to a burst of high-resolution structures of large macromolecular assemblies. ...
Cryo-electron microscopy (cryo-EM) of non-crystalline single particles is a biophysical technique that can be used to determine the structur …
Cryo-EM
Nogales E. Curr Biol 2018 - Review. PMID 30300591 Free PMC article.
Eva Nogales introduces cryo-electron microscopy used to visualize macromolecular structures....
Eva Nogales introduces cryo-electron microscopy used to visualize macromolecular structures....
Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites
Yoshizawa T, et al. Cell 2018. PMID 29677513 Free PMC article.
Liquid-liquid phase separation (LLPS) is believed to underlie formation of biomolecular condensates, cellular compartments that concentrate macromolecules without surrounding membranes. ...
Liquid-liquid phase separation (LLPS) is believed to underlie formation of biomolecular condensates, cellular compartments that concentrate …
Development of an antibody fragment that stabilizes GPCR/G-protein complexes
Maeda S, et al. Nat Commun 2018. PMID 30213947 Free PMC article.
Single-particle cryo-electron microscopy (cryo-EM) has recently enabled high-resolution structure determination of numerous biological macromolecular complexes. ...
Single-particle cryo-electron microscopy (cryo-EM) has recently enabled high-resolution structure determination of numerous biological ma
Mucins: the frontline defence of the lung
Ridley C and Thornton DJ. Biochem Soc Trans 2018 - Review. PMID 30154090 Free PMC article.
This mechanism of lung defence is reliant upon a flowing mucus gel, and the major macromolecular components that determine the rheological properties of mucus are the polymeric mucins, MUC5AC and MUC5B. ...Mucus with abnormal biophysical properties is a feature of muco-obstructive respiratory disease and can result from many different mechanisms including alterations in mucin polymer assembly, mucin concentration and the macromolecular form in mucus, as well as changes in airway surface hydration, pH and ion composition. ...
This mechanism of lung defence is reliant upon a flowing mucus gel, and the major macromolecular components that determine the rheolo …
Unravelling molecular complexity in structural cell biology
Pfeffer S and Mahamid J. Curr Opin Struct Biol 2018 - Review. PMID 30339965
Recent technological breakthroughs propelled electron microscopy of frozen hydrated specimens (cryo-EM) followed by single-particle analysis (SPA) to become a widely applied approach for obtaining near-atomic resolution structures of purified macromolecules. ...
Recent technological breakthroughs propelled electron microscopy of frozen hydrated specimens (cryo-EM) followed by single-particle analysis …
Toward an orthogonal central dogma
Liu CC, et al. Nat Chem Biol 2018. PMID 29337969 Free PMC article.
Biological Applications at the Cutting Edge of Cryo-Electron Microscopy
Dillard RS, et al. Microsc Microanal 2018 - Review. PMID 30175702 Free PMC article.
Cryo-electron microscopy (cryo-EM) is a powerful tool for macromolecular to near-atomic resolution structure determination in the biological sciences. ...Recent advances in sample preparation, imaging, and data processing have led to tremendous growth in the field of cryo-EM by providing higher resolution structures and the ability to investigate macromolecules within the context of the cell. ...
Cryo-electron microscopy (cryo-EM) is a powerful tool for macromolecular to near-atomic resolution structure determination in the bio …
56,646 results
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