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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1989 2
1990 9
1991 14
1992 27
1993 45
1994 50
1995 82
1996 117
1997 140
1998 191
1999 206
2000 223
2001 208
2002 190
2003 195
2004 178
2005 208
2006 170
2007 127
2008 24
2009 20
2010 20
2011 18
2012 19
2013 13
2014 10
2015 15
2016 11
2017 3
2018 11
2019 5
2020 0
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2,448 results
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Page 1
Myc Cooperates with Ras by Programming Inflammation and Immune Suppression
Kortlever RM, et al. Cell 2017. PMID 29195074 Free PMC article.
In a mouse lung model of KRas(G12D)-driven adenomas, we find that co-activation of Myc drives the immediate transition to highly proliferative and invasive adenocarcinomas marked by highly inflammatory, angiogenic, and immune-suppressed stroma. ...
In a mouse lung model of KRas(G12D)-driven adenomas, we find that co-activation of Myc drives the immediate transition to highly proliferati …
Involvement of Macrophage Inflammatory Protein-1 Family Members in the Development of Diabetic Neuropathy and Their Contribution to Effectiveness of Morphine.
Rojewska E, et al. Front Immunol 2018. PMID 29593735 Free PMC article.
Therefore, the goal of our study was to evaluate the participation of macrophage inflammatory protein-1 (MIP-1) family members (CCL3, CCL4, CCL9) in a streptozotocin (STZ)-induced mouse model of diabetic neuropathic pain. ...
Therefore, the goal of our study was to evaluate the participation of macrophage inflammatory protein-1 (MIP-1) family members …
Increased Levels of Macrophage Inflammatory Proteins Result in Resistance to R5-Tropic HIV-1 in a Subset of Elite Controllers.
Walker WE, et al. J Virol 2015. PMID 25740989 Free PMC article.
Notably, the genes encoding macrophage inflammatory protein 1α (MIP-1α), CCL3 and CCL3L1, were found to be upregulated. The MIP-1α, MIP-1β, and RANTES chemokines are natural ligands of CCR5 and are known to interfere with HIV replication. ...
Notably, the genes encoding macrophage inflammatory protein 1α (MIP-1α), CCL3 and CCL3L1, were found to be upregulated. The MI …
Macrophage inflammatory protein 1 and CCR5 as attractive therapeutic targets for HIV infection.
Kasama T, et al. Recent Pat Antiinfect Drug Discov 2006 - Review. PMID 18221152
Chemokines play key roles in inflammatory and immune responses mediated by their respective target cell populations. For instance, release of chemokines from inflammatory cells is a crucial step in the recruitment of cells needed to establish local inflammatory responses (e.g. rheumatoid arthritis). ...Studies have shown that the chemokine receptor CCR5 serves as a critical coreceptor during the viral entry stage of HIV infection, while its ligands macrophage inflammatory protein (MIP)-1alpha and beta and RANTES act as endogenous inhibitors of HIV infection. ...
Chemokines play key roles in inflammatory and immune responses mediated by their respective target cell populations. For instance, re …
Macrophage inflammatory protein (MIP)1alpha and MIP1beta differentially regulate release of inflammatory cytokines and generation of tumoricidal monocytes in malignancy.
Nath A, et al. Cancer Immunol Immunother 2006. PMID 16518599
The C-C chemokines, macrophage inflammatory protein (MIP)1alpha and MIP1beta are potent chemoattractants for the monocytes, which form an important component of the stroma of tumor tissue and may regulate tumor growth and associated inflammation. We examined the role of MIP1alpha and MIP1beta in inducing the release of inflammatory cytokines and the generation of tumoricidal monocytes from the peripheral blood monocytes (PBM) of healthy women and patients with carcinoma of breast (CaBr). ...
The C-C chemokines, macrophage inflammatory protein (MIP)1alpha and MIP1beta are potent chemoattractants for the monocytes, wh …
Fenretinide inhibits macrophage inflammatory mediators and controls hypertension in spontaneously hypertensive rats via the peroxisome proliferator-activated receptor gamma pathway.
Lin CH, et al. Drug Des Devel Ther 2016. PMID 27843299 Free PMC article.
In addition, LPS-induced pro-inflammatory cytokine production, including tumor necrosis factor-α, interleukin 6, and monocyte chemoattractant protein 1 were dose-dependently reversed by fenretinide, and the effects of fenretinide on LPS-induced pro-inflammatory cytokine production were blocked by treatment with PPARγ antagonist. ...In view of the role of inflammation in hypertension and the anti-inflammatory action of fenretinide, we found that administration of fenretinide in spontaneously hypertensive rats significantly decreased blood pressure. ...
In addition, LPS-induced pro-inflammatory cytokine production, including tumor necrosis factor-α, interleukin 6, and monocyte chemoat …
Systemic administration of the chemokine macrophage inflammatory protein 1alpha exacerbates inflammatory bowel disease in a mouse model.
Pender SL, et al. Gut 2005. PMID 16009684 Free PMC article.
INTRODUCTION: Exacerbations of inflammatory bowel disease are thought to be related to concurrent infections. As infections are associated with elevated local and serum concentrations of chemokines, we have determined whether systemic administration of the CC chemokine macrophage inflammatory protein 1alpha (MIP-1alpha) exacerbates colitis in a mouse model. ...Our findings also suggest a potential pathway by which peripheral infections can exacerbate inflammatory bowel disease....
INTRODUCTION: Exacerbations of inflammatory bowel disease are thought to be related to concurrent infections. As infections are assoc …
Oral exposure to cadmium chloride triggers an acute inflammatory response in the intestines of mice, initiated by the over-expression of tissue macrophage inflammatory protein-2 mRNA.
Zhao Z, et al. Toxicol Lett 2006. PMID 16413704
We investigated in the present study the acute inflammatory response in the intestines of mice orally challenged with a single dose of cadmium chloride (CdCl(2)) by determining the gene expression of pro-inflammatory mediators with real-time PCR, and by examining the infiltration of inflammatory cells with a myeloperoxidase (MPO) assay and histological analysis of hematoxylin and eosin (H&E)-stained intestinal sections. The results show that CdCl(2) significantly increased the expression of macrophage inflammatory protein-2 mRNA (30-40 times the normal level) 3h and the activity of MPO (about 2 times the normal level) 24h after the challenge in the duodenal and proximal jejunal tissue. ...
We investigated in the present study the acute inflammatory response in the intestines of mice orally challenged with a single dose o …
Effects and Mechanism of Nano-Copper Exposure on Hepatic Cytochrome P450 Enzymes in Rats
Tang H, et al. Int J Mol Sci 2018. PMID 30041454 Free PMC article.
Histopathological, inflammatory and oxidative stress were measured in the livers of all rats. The mRNA levels and activity of CYP450 enzymes, as well as the mRNA levels of select nuclear receptors, were determined. Exposure to nano-copper (400 mg/kg) induced significant oxidative stress and inflammation relative to the controls, indicated by increased levels of interleukin (IL)-2, IL-6, interferon (IFN)-γ, macrophage inflammatory protein (MIP-1), total antioxidant capacity (T-AOC), malondialdehyde (MDA), inducible nitric oxide synthase (iNOS) and nitric oxide (NO) after exposure. ...
Histopathological, inflammatory and oxidative stress were measured in the livers of all rats. The mRNA levels and activity of CYP450 …
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