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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1964 1
1965 9
1966 18
1967 34
1968 59
1969 40
1970 55
1971 72
1972 92
1973 96
1974 206
1975 299
1976 268
1977 303
1978 305
1979 360
1980 373
1981 361
1982 431
1983 466
1984 476
1985 475
1986 477
1987 441
1988 447
1989 412
1990 495
1991 512
1992 447
1993 479
1994 520
1995 524
1996 570
1997 573
1998 553
1999 637
2000 702
2001 705
2002 689
2003 672
2004 690
2005 830
2006 909
2007 976
2008 982
2009 1007
2010 1106
2011 1217
2012 1224
2013 1296
2014 1290
2015 1249
2016 1145
2017 1087
2018 1076
2019 430
2020 4
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29,108 results
Results by year
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Page 1
Liver macrophages in tissue homeostasis and disease.
Krenkel O and Tacke F. Nat Rev Immunol 2017 - Review. PMID 28317925
Macrophages represent a key cellular component of the liver, and are essential for maintaining tissue homeostasis and ensuring rapid responses to hepatic injury. Our understanding of liver macrophages has been revolutionized by the delineation of heterogeneous subsets of these cells. Kupffer cells are a self-sustaining, liver-resident population of macrophages and can be distinguished from the monocyte-derived macrophages that rapidly accumulate in the injured liver. ...
Macrophages represent a key cellular component of the liver, and are essential for maintaining tissue homeostasis and ensuring rapid
F4/80 as a Major Macrophage Marker: The Case of the Peritoneum and Spleen.
Dos Anjos Cassado A. Results Probl Cell Differ 2017 - Review. PMID 28455709
This heterogeneity may be associated with tissue-specific functions; however, the presence of distinct macrophage populations within the same microenvironment indicates that macrophage heterogeneity may also be influenced outside of tissue specialization. ...In this context, two murine macrophage subtypes with distinct F4/80 expression patterns were recently found to coexist in the peritoneum, termed large peritoneal macrophages (LPMs) and small peritoneal macrophages (SPMs). ...
This heterogeneity may be associated with tissue-specific functions; however, the presence of distinct macrophage populations within …
Developmental control of macrophage function.
Bonnardel J and Guilliams M. Curr Opin Immunol 2018 - Review. PMID 29247852
This raises the fascinating possibility that what was once perceived as immense functional plasticity of macrophages could in fact come down to separate macrophage subsets performing distinct functions because of their differential cellular origin. The question of macrophage plasticity versus macrophage heterogeneity is broader than the difference between macrophages of embryonic or adult hematopoietic origin and is particularly relevant in the context of inflammation. ...
This raises the fascinating possibility that what was once perceived as immense functional plasticity of macrophages could in fact co …
The development and maintenance of resident macrophages.
Perdiguero EG and Geissmann F. Nat Immunol 2016 - Review. PMID 26681456 Free PMC article.
The molecular and cellular mechanisms that underlie the many roles of macrophages in health and disease states in vivo remain poorly understood. The purpose of this Review is to present and discuss current knowledge on the developmental biology of macrophages, as it underlies the concept of a layered myeloid system composed of 'resident' macrophages that originate mainly from progenitor cells generated in the yolk sac and of 'passenger' or 'transitory' myeloid cells that originate and renew from bone marrow hematopoietic stem cells, and to provide a framework for investigating the functions of macrophages in vivo....
The molecular and cellular mechanisms that underlie the many roles of macrophages in health and disease states in vivo remain poorly …
Early hematopoiesis and macrophage development.
McGrath KE, et al. Semin Immunol 2015 - Review. PMID 27021646 Free PMC article.
The first wave of hematopoiesis contains primitive erythroid, megakaryocyte and macrophage progenitors that arise in the yolk sac, and these macrophage progenitors are the source of early macrophages throughout the embryo, including the liver. ...EMPs colonize the fetal liver, initiating myelopoiesis and forming macrophages. Lineage tracing indicates that this second wave of macrophages are distributed in most fetal tissues, although not appreciably in the brain. ...
The first wave of hematopoiesis contains primitive erythroid, megakaryocyte and macrophage progenitors that arise in the yolk sac, an …
Phagocytosis in cellular defense and nutrition: a food-centered approach to the evolution of macrophages.
Hartenstein V and Martinez P. Cell Tissue Res 2019 - Review. PMID 31485720 Free PMC article.
These are the ("professional") macrophages, motile cells that seek out and eliminate pathogenic invaders or damaged cells. Macrophages form the backbone of the innate immune system. ...Intensive research has revealed in detail molecular and cellular mechanisms of phagocytosis and intracellular digestion in macrophages. ...
These are the ("professional") macrophages, motile cells that seek out and eliminate pathogenic invaders or damaged cells. Macroph
Transcriptional Characteristics of Activated Macrophages.
Glanz V, et al. Curr Pharm Des 2019 - Review. PMID 30892154
Macrophages are key players in human innate immunity that protect the organism from pathologic agents, including infection and malignant cells. ...For many genes, the exact role in macrophage biology remains unknown, although clear associations with pro- or anti-inflammatory macrophage polarization could be demonstrated. ...
Macrophages are key players in human innate immunity that protect the organism from pathologic agents, including infection and malign
Focusing on Phagocytes
Carmi I. Dev Cell 2016. PMID 27459059
High-dose PMA with RANKL and MCSF induces THP‑1 cell differentiation into human functional osteoclasts in vitro
Li ZH, et al. Mol Med Rep 2017. PMID 28983613
Suspended THP‑1 cells were stimulated for 2 days with 5 or 100 ng/ml phorbol‑12 myristate‑13 acetate (PMA) in order to induce the cells to differentiate into adherent macrophages. A 10‑day stimulation with 50 ng/ml receptor activator of nuclear factor κ‑B ligand (RANKL) and macrophage colony‑stimulating factor (MCSF) was performed in order to induce macrophage differentiation into osteoclasts. ...
Suspended THP‑1 cells were stimulated for 2 days with 5 or 100 ng/ml phorbol‑12 myristate‑13 acetate (PMA) in order to induce the cells to d …
29,108 results
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