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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1958 4
1959 5
1960 4
1961 4
1962 5
1963 2
1964 2
1965 19
1966 57
1967 106
1968 160
1969 265
1970 355
1971 476
1972 484
1973 671
1974 724
1975 829
1976 886
1977 948
1978 1045
1979 1239
1980 1300
1981 1221
1982 1545
1983 1507
1984 1625
1985 1798
1986 1835
1987 1651
1988 1805
1989 1947
1990 1957
1991 2095
1992 2061
1993 2121
1994 2301
1995 2294
1996 2249
1997 2274
1998 2478
1999 2520
2000 2752
2001 2829
2002 2842
2003 2940
2004 3048
2005 3540
2006 3668
2007 3765
2008 4066
2009 4224
2010 4522
2011 4889
2012 5391
2013 5710
2014 5788
2015 6085
2016 5838
2017 5939
2018 5830
2019 2569
2020 45
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123,601 results
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Page 1
Macrophage plasticity, polarization, and function in health and disease.
Shapouri-Moghaddam A, et al. J Cell Physiol 2018 - Review. PMID 29319160
Macrophages are heterogeneous and their phenotype and functions are regulated by the surrounding micro-environment. Macrophages commonly exist in two distinct subsets: 1) Classically activated or M1 macrophages, which are pro-inflammatory and polarized by lipopolysaccharide (LPS) either alone or in association with Th1 cytokines such as IFN-γ, GM-CSF, and produce pro-inflammatory cytokines such as interleukin-1β (IL-1β), IL-6, IL-12, IL-23, and TNF-α; and 2) Alternatively activated or M2 macrophages, which are anti-inflammatory and immunoregulatory and polarized by Th2 cytokines such as IL-4 and IL-13 and produce anti-inflammatory cytokines such as IL-10 and TGF-β. ...It is known that M1/M2 macrophage balance polarization governs the fate of an organ in inflammation or injury. When the infection or inflammation is severe enough to affect an organ, macrophages first exhibit the M1 phenotype to release TNF-α, IL-1β, IL-12, and IL-23 against the stimulus. ...
Macrophages are heterogeneous and their phenotype and functions are regulated by the surrounding micro-environment. Macrophages
Macrophages: development and tissue specialization.
Varol C, et al. Annu Rev Immunol 2015 - Review. PMID 25861979
Here we review two major recent paradigm shifts in our understanding of tissue macrophage biology. The first is the realization that most tissue-resident macrophages are established prenatally and maintained through adulthood by longevity and self-renewal. ...Factors that govern tissue macrophage specialization are emerging. Moreover, tissue specialization is reflected in discrete gene expression profiles of macrophages, as well as epigenetic signatures reporting actual and potential enhancer usage....
Here we review two major recent paradigm shifts in our understanding of tissue macrophage biology. The first is the realization that …
Macrophage Immunometabolism: Where Are We (Going)?
Van den Bossche J, et al. Trends Immunol 2017 - Review. PMID 28396078
A growing number of findings highlight the crucial role of metabolic reprogramming in macrophage activation. Metabolic pathways are closely interconnected and recent literature demonstrates the need for glucose metabolism in anti-inflammatory as well as inflammatory macrophages. Moreover, fatty acid oxidation (FAO) not only supports anti-inflammatory responses as described formerly but also drives inflammasome activation in inflammatory macrophages. ...
A growing number of findings highlight the crucial role of metabolic reprogramming in macrophage activation. Metabolic pathways are c …
Macrophages in inflammation.
Fujiwara N and Kobayashi K. Curr Drug Targets Inflamm Allergy 2005 - Review. PMID 16101534
Macrophages are a major component of the mononuclear phagocyte system that consists of closely related cells of bone marrow origin, including blood monocytes, and tissue macrophages. ...Activated macrophages are deactivated by anti-inflammatory cytokines (interleukin 10 and transforming growth factor beta) and cytokine antagonists that are mainly produced by macrophages. ...
Macrophages are a major component of the mononuclear phagocyte system that consists of closely related cells of bone marrow origin, i
The Role of Macrophages in the Pathogenesis of ALI/ARDS.
Huang X, et al. Mediators Inflamm 2018 - Review. PMID 29950923 Free PMC article.
Apart from leukocytes and endothelial cells, macrophages are also essential for the process of the inflammatory response in ALI/ARDS. Notably, macrophages play a dual role of proinflammation and anti-inflammation based on the microenvironment in different pathological stages. ...
Apart from leukocytes and endothelial cells, macrophages are also essential for the process of the inflammatory response in ALI/ARDS. …
Mechanisms of foam cell formation in atherosclerosis
Chistiakov DA, et al. J Mol Med (Berl) 2017 - Review. PMID 28785870
Low-density lipoprotein (LDL) and cholesterol homeostasis in the peripheral blood is maintained by specialized cells, such as macrophages. Macrophages express a variety of scavenger receptors (SR) that interact with lipoproteins, including SR-A1, CD36, and lectin-like oxLDL receptor-1 (LOX-1). ...
Low-density lipoprotein (LDL) and cholesterol homeostasis in the peripheral blood is maintained by specialized cells, such as macrophages
MiRNA-Mediated Macrophage Polarization and its Potential Role in the Regulation of Inflammatory Response.
Essandoh K, et al. Shock 2016 - Review. PMID 26954942 Free PMC article.
Essential to such functions is classical activation (M1) and alternative activation (M2) of macrophages. M1 polarization of macrophages is characterized by production of pro-inflammatory cytokines, antimicrobial and tumoricidal activity, whereas M2 polarization of macrophages is linked to immunosuppression, tumorigenesis, wound repair, and elimination of parasites. ...This review highlights recent findings in miRNA expression profiles in polarized macrophages from murine and human sources, and summarizes how these miRNAs regulate macrophage polarization. ...
Essential to such functions is classical activation (M1) and alternative activation (M2) of macrophages. M1 polarization of macrop
The role of macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis.
Kazankov K, et al. Nat Rev Gastroenterol Hepatol 2019 - Review. PMID 30482910
In this process, not only the polarization of liver macrophages towards a pro-inflammatory phenotype is important, but adipose tissue macrophages, especially in the visceral compartment, also contribute to disease severity and insulin resistance. ...Reflecting the important role of macrophages in NASH, we also review studies investigating drugs that target macrophage recruitment to the liver, macrophage polarization and their inflammatory effects as potential treatment options for patients with NASH....
In this process, not only the polarization of liver macrophages towards a pro-inflammatory phenotype is important, but adipose tissue …
Regulation of macrophage immunometabolism in atherosclerosis.
Koelwyn GJ, et al. Nat Immunol 2018 - Review. PMID 29777212 Free PMC article.
In atherosclerosis, in which macrophages play central roles in the initiation, growth, and ultimately rupture of arterial plaques, altered metabolism is a key feature that dictates macrophage function and subsequent disease progression. ...Finally, this overview offers insight into the challenges and opportunities of harnessing metabolism to modulate aberrant macrophage responses in disease....
In atherosclerosis, in which macrophages play central roles in the initiation, growth, and ultimately rupture of arterial plaques, al …
Macrophages and the Recovery from Acute and Chronic Inflammation.
Hamidzadeh K, et al. Annu Rev Physiol 2017 - Review. PMID 27959619 Free PMC article.
In recent years, researchers have devoted much attention to the diverse roles of macrophages and their contributions to tissue development, wound healing, and angiogenesis. ...In simple terms, macrophages can thus be viewed as incendiary devices with hair triggers waiting to detonate. We have begun to ask questions about how these cells can be regulated to mitigate the collateral destruction associated with macrophage activation....
In recent years, researchers have devoted much attention to the diverse roles of macrophages and their contributions to tissue develo …
123,601 results
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