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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1966 1
1967 2
1968 1
1969 1
1970 2
1971 6
1972 11
1973 14
1974 10
1975 9
1976 8
1977 8
1978 16
1979 14
1980 17
1981 15
1982 15
1983 13
1984 10
1985 13
1986 27
1987 17
1988 23
1989 32
1990 29
1991 35
1992 26
1993 21
1994 40
1995 44
1996 47
1997 46
1998 41
1999 50
2000 54
2001 61
2002 59
2003 53
2004 43
2005 55
2006 46
2007 34
2008 41
2009 28
2010 44
2011 46
2012 37
2013 30
2014 21
2015 19
2016 18
2017 18
2018 17
2019 13
2020 0
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1,345 results
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Page 1
Rodent Models Assessing Mammary Tumor Prevention by Soy or Soy Isoflavones.
Moorehead RA. Genes (Basel) 2019 - Review. PMID 31357528 Free PMC article.
In an attempt to model the preventative actions of soy on mammary tumor development, rodent models have been employed. Thirty-four studies were identified that evaluated the impact of soy products or purified soy isoflavones on mammary tumor initiation (studies evaluating established mammary tumors or mammary tumor cell lines were not included) and these studies were separated into mammary tumors induced by chemical carcinogens or transgenic expression of oncogenes based on the timing of soy administration. Regardless of when soy-based diets or purified isoflavones were administered, no consistent protective effects were observed in either carcinogen-induced or oncogene-induced mammary tumors. ...
In an attempt to model the preventative actions of soy on mammary tumor development, rodent models have been employed. Thirty-four st …
Multi-targeting chemoprevention of Chinese herb formula Yanghe Huayan decoction on experimentally induced mammary tumorigenesis.
Li J, et al. BMC Complement Altern Med 2019. PMID 30760265 Free PMC article.
Mammary tumor occurrence was monitored every day. The length of time before palpable tumor is examined is defined as tumor-free survival time. ...Eight major chemical compositions of the decoction were identified and were shown to interfere with multiple tumorigenic pathways simultaneously in the mammary tumors, including inducing tumor apoptosis and up-regulating pro-apoptotic protein Bax and down-regulating anti-apoptotic protein Bcl-2; suppressing abnormal cell proliferation and the MAPK/ERK, PI3K/AKT signalings; blocking neo-angiogenesis and the VEGF/KDR signaling, and inhibiting oxidative stress in the mammary tumors. ...
Mammary tumor occurrence was monitored every day. The length of time before palpable tumor is examined is defined as tumor-free survi
Chemoprevention of Preclinical Breast and Lung Cancer with the Bromodomain Inhibitor I-BET 762
Zhang D, et al. Cancer Prev Res (Phila) 2018. PMID 29246957 Free article.
Because of limited success in reducing the high mortality of these diseases, new drugs and approaches are desperately needed. ...I-BET 762 is a new bromodomain inhibitor that reversibly targets BET (bromodomain and extraterminal) proteins and impairs their ability to bind to acetylated lysines on histones, thus interrupting downstream transcription. ...
Because of limited success in reducing the high mortality of these diseases, new drugs and approaches are desperately needed. …
Combinatorial effect of zoledronic acid and irradiation on the prevention of DMBA-induced precancerogenic changes in the mammary tissues of rats.
G Rocak S, et al. J Cancer Res Ther 2016. PMID 27461625 Free article.
Hence, the development of new breast cancer chemopreventive drugs with acceptable efficacy and toxicity that are suitable for use for a protracted period of time is urgently needed. ...Our results suggest that the administration of ZOL and irradiation in combination can offer maximal protection against DMBA-induced mammary precancerogenic changes....
Hence, the development of new breast cancer chemopreventive drugs with acceptable efficacy and toxicity that are suitable for use for …
Chemoprevention of N-nitroso-N-methylurea-induced rat mammary cancer by miso and tamoxifen, alone and in combination.
Gotoh T, et al. Jpn J Cancer Res 1998. PMID 9685851 Free PMC article.
We examined the effects of a Japanese fermented soybean product, miso, and tamoxifen (TAM), alone and in combination, on N-nitroso-N-methylurea (MNU)-induced rat mammary cancer. ...In the second experiment, the effect of the combination of miso and TAM on established rat mammary tumors was investigated. When the mammary tumors induced by MNU reached 10 to 25 mm, the rats were divided into 3 treatment groups: regular diet, regular diet + TAM, and 10% miso diet + TAM. ...
We examined the effects of a Japanese fermented soybean product, miso, and tamoxifen (TAM), alone and in combination, on N-nitroso-N-methylu …
Pomegranate exerts chemoprevention of experimentally induced mammary tumorigenesis by suppression of cell proliferation and induction of apoptosis.
Bishayee A, et al. Nutr Cancer 2016. PMID 26699876 Free PMC article.
Breast cancer is the second leading cause of cancer-related death in women in the United States and discovery and development of safe chemopreventive drugs is urgently needed. ...PE exhibited a striking reduction of DMBA-induced mammary tumor incidence, total tumor burden, and reversed histopathological changes. ...
Breast cancer is the second leading cause of cancer-related death in women in the United States and discovery and development of safe chemop …
Low-calorie diet prevents the development of mammary tumors in C3H mice and reduces circulating prolactin level, murine mammary tumor virus expression, and proliferation of mammary alveolar cells.
Sarkar NH, et al. Proc Natl Acad Sci U S A 1982. PMID 6296850 Free PMC article.
In order to understand the mechanism by which a low-calorie diet decreases the occurrence of mammary tumors in mice, we compared the sex cycle, the amounts of circulating thyroid-stimulating hormone (thyrotropin), growth hormone, and prolactin, the production of type A and B virus particles in the mammary glands, and the morphology of the mammary glands of mice fed low- and high-calorie diets. ...Our findings suggest that the reduction in serum prolactin level, mammary tumor virus production, and proliferation of mammary alveolar lesions associated with dietary calorie restriction is responsible for lowering the incidence of mammary tumors in mice....
In order to understand the mechanism by which a low-calorie diet decreases the occurrence of mammary tumors in mice, we compared the …
Dietary effects of soy isoflavones daidzein and genistein on 7,12-dimethylbenz[a]anthracene-induced mammary mutagenesis and carcinogenesis in ovariectomized Big Blue transgenic rats.
Manjanatha MG, et al. Carcinogenesis 2006. PMID 17127718
In general, feeding the isoflavones or E2 separately did not cause any significant changes in DMBA-induced mutagenicity in the mammary. ...Mammary histology indicated that hyperplasia was induced in most of the treatment groups including control. Although DMBA treatment did not induce mammary tumors in the OVX rats, adenoma and adenocarcinoma were detected in the mammary glands of INT rats....
In general, feeding the isoflavones or E2 separately did not cause any significant changes in DMBA-induced mutagenicity in the mammary
Chemopreventive effects of hydatid disease on experimental breast cancer
Altun A, et al. Asian Pac J Cancer Prev 2015. PMID 25743804 Free article.
Since there have been significant improvements in treatment of breast cancer, there is still a big need for alternative approaches. ...Then DMBA was applied to mammary tissues of all rats. Immunohistochemistry studies for Ki-67 and S-100 in the tumoral tissue sections of DMBA induced mammary tumor in rats were performed. ...
Since there have been significant improvements in treatment of breast cancer, there is still a big need for alternative approaches. . …
Prevention of mammary carcinogenesis in C3H/OuJ mice by green tea and tamoxifen.
Sakata M, et al. Asian Pac J Cancer Prev 2011. PMID 21545231 Free article.
In this study, we investigated their effects, alone or in combination, on mammary carcinogenesis using breast cancer cells and preneoplastic lesions inC3H/OuJ mice. ...The number and size of mammary tumors were measured weekly during treatment. At 48 weeks of age, mice were sacrificed for the examination of hyperplastic alveolar nodules (HAN) and argyrophilic nucleolar organizer regions (AgNOR). ...
In this study, we investigated their effects, alone or in combination, on mammary carcinogenesis using breast cancer cells and preneo …
1,345 results
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