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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2005 4
2006 27
2007 43
2008 51
2009 74
2010 67
2011 68
2012 87
2013 85
2014 73
2015 89
2016 77
2017 98
2018 77
2019 43
2020 0
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825 results
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Page 1
Matrix metalloproteinase-13 refines pathological staging of precancerous colorectal lesions.
Wernicke AK, et al. Oncotarget 2016. PMID 27716617 Free PMC article.
Here we investigate the association between grade of dysplasia and Matrix metalloproteinase-13 (MMP-13) expression in 137 biopsies from patients with cancerous and non-cancerous colorectal adenomas. ...A newly adopted immunoreactive scoring system for MMP-13 was demonstrated as reliable readout.The strength of the association between pathologic stage and immunoreactive MMP-13 scoring emphasizes its eligibility for diagnosis in precancerous colorectal lesions....
Here we investigate the association between grade of dysplasia and Matrix metalloproteinase-13 (MMP-13) expressi …
Matrix metalloproteinase-13: A special focus on its regulation by signaling cascades and microRNAs in bone.
S S, et al. Int J Biol Macromol 2018 - Review. PMID 29273522
Bone remodeling is an orchestrated process involving osteoblasts and osteoclasts to maintain mineral homeostasis in the internal milieu, mediated chiefly by matrix metalloproteinases (MMPs). ...
Bone remodeling is an orchestrated process involving osteoblasts and osteoclasts to maintain mineral homeostasis in the internal milieu, med …
Interferonregulatoryfactor-8(IRF-8) regulates the expression of matrix metalloproteinase-13 (MMP-13) in chondrocytes.
Yang Q, et al. Cell Stress Chaperones 2018. PMID 29247272 Free PMC article.
Low levels of inflammation-induced expression of matrix metalloproteinase (MMP) play a crucial role in articular cartilage matrix destruction in osteoarthritis (OA) patients. ...Overexpression of IRF-8 in human chondrocytes by transduction with lentiviral-IRF-8 exacerbated IL-1β-induced expression of matrix metalloproteinase-13 (MMP-13) in human chondrocytes. ...
Low levels of inflammation-induced expression of matrix metalloproteinase (MMP) play a crucial role in articular cartilage …
Matrix metalloproteinase-13 participates in neuroprotection and neurorepair after cerebral ischemia in mice.
Ma F, et al. Neurobiol Dis 2016. PMID 27001146
One approach is the remodeling of extracellular matrix, which participates in both brain injury and neurovascular repair when matrix metalloproteinases (MMPs) are thought to be key players. Our aim was to investigate the role of MMP-13 (collagenase-3) in the acute (24h and 3days) and delayed (2weeks) phases of stroke. ...
One approach is the remodeling of extracellular matrix, which participates in both brain injury and neurovascular repair when matr
Parathyroid hormone-induced down-regulation of miR-532-5p for matrix metalloproteinase-13 expression in rat osteoblasts.
Mohanakrishnan V, et al. J Cell Biochem 2018. PMID 29626351
We previously reported that PTH stimulates the expression of matrix metalloproteinase-13 (MMP-13) in rat osteoblasts and that MMP-13 plays a key role in bone remodeling, endochondral bone formation, and bone repair. ...In this study, we hypothesized that the down-regulation of miRNAs that target MMP-13 by PTH leads to the stimulation of MMP-13 expression in osteoblasts. ...
We previously reported that PTH stimulates the expression of matrix metalloproteinase-13 (MMP-13) in rat osteobl …
Hypoxia-Induced Matrix Metalloproteinase-13 Expression in Exosomes from Nasopharyngeal Carcinoma Enhances Metastases.
Shan Y, et al. Cell Death Dis 2018. PMID 29515112 Free PMC article.
HIF-1α rapidly accumulates and trans-activates hundreds of genes, such as matrix metalloproteinases (MMPs). We found that MMP-13 was over-expressed in exosomes and cells under hypoxic conditions. HIF-1α depletion in hypoxic CNE2 cells led to decreased MMP-13 levels in exosomes and significantly reduced cell migration and invasion. ...
HIF-1α rapidly accumulates and trans-activates hundreds of genes, such as matrix metalloproteinases (MMPs). We found that MMP- …
Glucocorticoids induce apoptosis and matrix metalloproteinase-13 expression in chondrocytes through the NOX4/ROS/p38 MAPK pathway.
Huang Y, et al. J Steroid Biochem Mol Biol 2018. PMID 29526705
Changes in matrix metalloproteinase 13 (MMP-13) expression levels in Dex-treated chondrocytes were also investigated. The Dex treatment increased NOX4 expression via the glucocorticoid receptor (GR). ...Moreover, treatment of cells with these agents blocked MMP-13 expression in Dex-treated chondrocytes. NOX4 silencing also suppressed p38 MAPK and MMP-13 expression. ...
Changes in matrix metalloproteinase 13 (MMP-13) expression levels in Dex-treated chondrocytes were also investig …
Downregulation of microRNA-9 increases matrix metalloproteinase-13 expression levels and facilitates osteoarthritis onset.
Zhang H, et al. Mol Med Rep 2018. PMID 29286096 Free PMC article.
Matrix metalloproteinase-13 (MMP-13) degrades collagen and other matrix components, thus playing a critical role in the development of osteoarthritis (OA). ...
Matrix metalloproteinase-13 (MMP-13) degrades collagen and other matrix components, thus playing a critic
Expression analysis of matrix metalloproteinase-13 in human gastric cancer in the presence of Helicobacter Pylori infection.
Sheibani S, et al. Cancer Biomark 2017. PMID 28128735
BACKGROUND: Matrix metalloproteinases (MMPs) can degrade essentially the extracellular matrix (ECM) components. MMPs are important regulators of tumor growth; hence the enzymes are considered as important targets for cancer therapy. ...RESULTS: The results showed 30% elevation of MMP-13 expression in tumor tissues. H.pylori infection did not have a significant effect on the expression of MMP-13. ...
BACKGROUND: Matrix metalloproteinases (MMPs) can degrade essentially the extracellular matrix (ECM) components. MMPs ar …
FOXO3a (Forkhead Transcription Factor O Subfamily Member 3a) Links Vascular Smooth Muscle Cell Apoptosis, Matrix Breakdown, Atherosclerosis, and Vascular Remodeling Through a Novel Pathway Involving MMP13 (Matrix Metalloproteinase 13).
Yu H, et al. Arterioscler Thromb Vasc Biol 2018. PMID 29326312 Free PMC article.
APPROACH AND RESULTS: Expression of a conditional FOXO3a allele (FOXO3aA3ER) potently induced VSMC apoptosis, expression and activation of MMP13 (matrix metalloproteinase 13), and downregulation of endogenous TIMPs (tissue inhibitors of MMPs). mmp13 and mmp2 were direct FOXO3a transcriptional targets in VSMCs. ...FOXO3a-induced MMP activation represents a direct mechanistic link between VSMC apoptosis and matrix breakdown in vascular disease....
APPROACH AND RESULTS: Expression of a conditional FOXO3a allele (FOXO3aA3ER) potently induced VSMC apoptosis, expression and activation of M …
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