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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2003 1
2005 2
2006 20
2007 44
2008 57
2009 69
2010 59
2011 57
2012 59
2013 61
2014 54
2015 73
2016 63
2017 59
2018 46
2019 33
2020 0
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654 results
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Page 1
Targeting matrix metalloproteinase-13 in bronchial epithelial repair.
Howell C, et al. Clin Exp Allergy 2018. PMID 29924890
OBJECTIVE: The objective was to test the hypothesis that poly I:C, a model of viral infection, limits epithelial repair through the stimulated release of matrix metalloproteinase-13 (MMP-13). ...Bosentan enhanced the rate of bronchial epithelial repair by a mechanism that was independent of MMP-13. CONCLUSIONS AND CLINICAL RELEVANCE: Bronchial epithelial repair is limited by endothelin and by MMP-13, a protease that degrades coagulation factors, such as fibrinogen, and matrix proteins essential for epithelial repair. ...
OBJECTIVE: The objective was to test the hypothesis that poly I:C, a model of viral infection, limits epithelial repair through the stimulat …
Interferonregulatoryfactor-8(IRF-8) regulates the expression of matrix metalloproteinase-13 (MMP-13) in chondrocytes.
Yang Q, et al. Cell Stress Chaperones 2018. PMID 29247272 Free PMC article.
Low levels of inflammation-induced expression of matrix metalloproteinase (MMP) play a crucial role in articular cartilage matrix destruction in osteoarthritis (OA) patients. ...Overexpression of IRF-8 in human chondrocytes by transduction with lentiviral-IRF-8 exacerbated IL-1β-induced expression of matrix metalloproteinase-13 (MMP-13) in human chondrocytes. ...
Low levels of inflammation-induced expression of matrix metalloproteinase (MMP) play a crucial role in articular cartilage …
Matrix metalloproteinase-13 refines pathological staging of precancerous colorectal lesions.
Wernicke AK, et al. Oncotarget 2016. PMID 27716617 Free PMC article.
Here we investigate the association between grade of dysplasia and Matrix metalloproteinase-13 (MMP-13) expression in 137 biopsies from patients with cancerous and non-cancerous colorectal adenomas. ...A newly adopted immunoreactive scoring system for MMP-13 was demonstrated as reliable readout.The strength of the association between pathologic stage and immunoreactive MMP-13 scoring emphasizes its eligibility for diagnosis in precancerous colorectal lesions....
Here we investigate the association between grade of dysplasia and Matrix metalloproteinase-13 (MMP-13) expressi …
Matrix metalloproteinase-13: A special focus on its regulation by signaling cascades and microRNAs in bone.
S S, et al. Int J Biol Macromol 2018 - Review. PMID 29273522
Bone remodeling is an orchestrated process involving osteoblasts and osteoclasts to maintain mineral homeostasis in the internal milieu, mediated chiefly by matrix metalloproteinases (MMPs). ...
Bone remodeling is an orchestrated process involving osteoblasts and osteoclasts to maintain mineral homeostasis in the internal milieu, med …
Matrix metalloproteinase 13-containing exosomes promote nasopharyngeal carcinoma metastasis.
You Y, et al. Cancer Sci 2015. PMID 26362844 Free PMC article.
Matrix metalloproteinase 13 is an important kind of matrix proteinase that is often overexpressed in various tumors and increases the risk of metastasis. ...
Matrix metalloproteinase 13 is an important kind of matrix proteinase that is often overexpressed in various tum
Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development.
Little CB, et al. Arthritis Rheum 2009. PMID 19950295 Free PMC article.
OBJECTIVE: To investigate the role of matrix metalloproteinase 13 (MMP-13; collagenase 3) in osteoarthritis (OA). METHODS: OA was surgically induced in the knees of MMP-13-knockout mice and wild-type mice, and mice were compared. ...MMP-13 deficiency can inhibit cartilage erosion in the presence of aggrecan depletion, supporting the potential for therapeutic intervention in established OA with MMP-13 inhibitors....
OBJECTIVE: To investigate the role of matrix metalloproteinase 13 (MMP-13; collagenase 3) in osteoarthritis (OA) …
Matrix metalloproteinase-13 participates in neuroprotection and neurorepair after cerebral ischemia in mice.
Ma F, et al. Neurobiol Dis 2016. PMID 27001146
One approach is the remodeling of extracellular matrix, which participates in both brain injury and neurovascular repair when matrix metalloproteinases (MMPs) are thought to be key players. Our aim was to investigate the role of MMP-13 (collagenase-3) in the acute (24h and 3days) and delayed (2weeks) phases of stroke. ...
One approach is the remodeling of extracellular matrix, which participates in both brain injury and neurovascular repair when matr
Recent Research Advances in Selective Matrix Metalloproteinase-13 Inhibitors as Anti-Osteoarthritis Agents.
Xie XW, et al. ChemMedChem 2017 - Review. PMID 28722301
Matrix metalloproteinase-13 (MMP-13) plays a key role in the degradation of type II collagen in cartilage and bone in osteoarthritis (OA). The subtle differences between the S1' loop of MMP-13 and that of other MMPs offer a structural base for the design of selective MMP-13 inhibitors to mitigate the unperceived risk associated with inhibiting other MMP isoforms. ...
Matrix metalloproteinase-13 (MMP-13) plays a key role in the degradation of type II collagen in cartilage and bo
Parathyroid hormone-induced down-regulation of miR-532-5p for matrix metalloproteinase-13 expression in rat osteoblasts.
Mohanakrishnan V, et al. J Cell Biochem 2018. PMID 29626351
We previously reported that PTH stimulates the expression of matrix metalloproteinase-13 (MMP-13) in rat osteoblasts and that MMP-13 plays a key role in bone remodeling, endochondral bone formation, and bone repair. ...In this study, we hypothesized that the down-regulation of miRNAs that target MMP-13 by PTH leads to the stimulation of MMP-13 expression in osteoblasts. ...
We previously reported that PTH stimulates the expression of matrix metalloproteinase-13 (MMP-13) in rat osteobl …
Hypoxia-Induced Matrix Metalloproteinase-13 Expression in Exosomes from Nasopharyngeal Carcinoma Enhances Metastases.
Shan Y, et al. Cell Death Dis 2018. PMID 29515112 Free PMC article.
HIF-1α rapidly accumulates and trans-activates hundreds of genes, such as matrix metalloproteinases (MMPs). We found that MMP-13 was over-expressed in exosomes and cells under hypoxic conditions. HIF-1α depletion in hypoxic CNE2 cells led to decreased MMP-13 levels in exosomes and significantly reduced cell migration and invasion. ...
HIF-1α rapidly accumulates and trans-activates hundreds of genes, such as matrix metalloproteinases (MMPs). We found that MMP- …
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