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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1971 1
1972 1
1973 4
1975 1
1976 2
1977 1
1980 5
1981 4
1982 2
1983 3
1984 1
1985 1
1986 5
1987 6
1988 7
1989 5
1990 11
1991 8
1992 13
1993 10
1994 14
1995 33
1996 42
1997 59
1998 68
1999 68
2000 59
2001 73
2002 77
2003 65
2004 85
2005 106
2006 132
2007 102
2008 122
2009 104
2010 119
2011 139
2012 133
2013 132
2014 167
2015 192
2016 170
2017 171
2018 184
2019 93
2020 3
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2,535 results
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Page 1
Melatonin in Heart Failure: A Promising Therapeutic Strategy?
Nduhirabandi F and Maarman GJ. Molecules 2018 - Review. PMID 30037127 Free PMC article.
In this review, available evidence for the role of melatonin in heart failure is discussed. Current challenges and possible limitations of using melatonin in heart failure are also addressed. While few clinical studies have investigated the role of melatonin in the context of heart failure, current findings from experimental studies support the potential use of melatonin as preventive and adjunctive curative therapy in heart failure....
In this review, available evidence for the role of melatonin in heart failure is discussed. Current challenges and possible limitatio …
Recent developments in research of melatonin and its potential therapeutic applications.
Stanford SC. Br J Pharmacol 2018. PMID 30917240 Free PMC article.
This article is part of a themed section on Recent Developments in Research of Melatonin and its Potential Therapeutic Applications. ...
This article is part of a themed section on Recent Developments in Research of Melatonin and its Potential Therapeutic Applica …
Melatonin for the prevention and treatment of cancer.
Li Y, et al. Oncotarget 2017 - Review. PMID 28415828 Free PMC article.
The epidemiological studies have indicated a possible oncostatic property of melatonin on different types of tumors. Besides, experimental studies have documented that melatonin could exert growth inhibition on some human tumor cells in vitro and in animal models. ...Melatonin could also be utilized as adjuvant of cancer therapies, through reinforcing the therapeutic effects and reducing the side effects of chemotherapies or radiation. ...
The epidemiological studies have indicated a possible oncostatic property of melatonin on different types of tumors. Besides, experim …
Role of Melatonin in the Inflammatory Process and its Therapeutic Potential.
Carrascal L, et al. Curr Pharm Des 2018 - Review. PMID 29701146
Therapeutic assays with melatonin indicate that it has a beneficial therapeutic value in the treatment of several inflammatory diseases, such as Alzheimer, Amiotrophic Lateral, Multiple Sclerosis and Huntigton´s disease as well as ulcerative colitis. ...In this review we present the use of melatonin in the control of inflammation underlying the above mentioned diseases. These actions are mediated through their receptors but also with their direct antioxidant action and melatonin's ability to break the vicious cycle of ROSinflammation. ...
Therapeutic assays with melatonin indicate that it has a beneficial therapeutic value in the treatment of several infla
Therapeutic potential of melatonin in oral medicine and periodontology.
Najeeb S, et al. Kaohsiung J Med Sci 2016 - Review. PMID 27523451 Free article.
Research has suggested that melatonin is effective in treating the aforementioned pathologies. Furthermore, melatonin has been observed to enhance osseointegration and bone regeneration. ...Topical administration of melatonin has a positive effect on periodontal health and osseointegration. Furthermore, melatonin is particularly effective in improving the periodontal parameters of diabetic patients with periodontitis. ...
Research has suggested that melatonin is effective in treating the aforementioned pathologies. Furthermore, melatonin has been …
Sleep-related melatonin use in healthy children.
Janjua I and Goldman RD. Can Fam Physician 2016. PMID 27076541 Free PMC article.
Her job involves shift work and she uses melatonin herself to help her fall asleep. She asked if her son could take melatonin. ...For children with otherwise undiagnosed insomnia and healthy sleep hygiene, melatonin use should be considered. While melatonin seems to be safe, there is a lack of evidence for its routine use among healthy children....
Her job involves shift work and she uses melatonin herself to help her fall asleep. She asked if her son could take melatonin. …
Therapeutic role of melatonin in migraine prophylaxis: A systematic review.
Long R, et al. Medicine (Baltimore) 2019. PMID 30653130 Free PMC article.
Thus far, many diseases have been found to associate with melatonin, including the migraine. Therefore, melatonin's therapeutic potential for migraine is drawing attention. ...Future studies of perfect design in methodology, pharmacology, and therapeutics are needed to achieve a deeper awareness of melatonin's role in migraine as well as more studies to explore the safety issues of melatonin medicine....
Thus far, many diseases have been found to associate with melatonin, including the migraine. Therefore, melatonin's therape
An update on the use of melatonin as a stroke therapeutic.
Gonzales-Portillo GS, et al. Minerva Med 2015 - Review. PMID 25000217
Delivery of melatonin and targeting melatonin receptors pose as neuroprotective strategies for stroke therapy. The potential of melatonin-based therapeutics for clinical application in stroke patients requires translational research to guide the conduct of clinical trials. We review recent preclinical and clinical data that support the use of melatonin for stroke....
Delivery of melatonin and targeting melatonin receptors pose as neuroprotective strategies for stroke therapy. The potential o …
Does melatonin have therapeutic use in tinnitus?
Merrick L, et al. South Med J 2014 - Review. PMID 24945170
Some investigators have noted that melatonin may alleviate subjective symptoms of tinnitus. Moreover, melatonin may have properties protective against ototoxic drugs such as amikacin, gentamicin, or cancer therapeutic agents that are dose dependent. ...We recommend that melatonin be considered for use in patients with significant tinnitus....
Some investigators have noted that melatonin may alleviate subjective symptoms of tinnitus. Moreover, melatonin may have prope …
The potential use of melatonin to treat protozoan parasitic infections: A review.
Daryani A, et al. Biomed Pharmacother 2018 - Review. PMID 29136773
Due to the antioxidant and immunomodulatory effects of melatonin, it is suggested that this molecule could be a therapeutic alternative agent to fight bacterial, viral, and parasitic infections by a variety of mechanisms. ...In giardiasis, serum melatonin levels are elevated in these patients; this suggests a positive correlation between the level of melatonin and phagocytic activity in the G. duodenalis infected patients, possibly related to melatonin's immunomodulatory effect. ...
Due to the antioxidant and immunomodulatory effects of melatonin, it is suggested that this molecule could be a therapeutic al …
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