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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 3
1946 25
1947 30
1948 22
1949 24
1950 33
1951 31
1952 37
1953 50
1954 47
1955 68
1956 73
1957 87
1958 91
1959 95
1960 78
1961 98
1962 94
1963 94
1964 150
1965 69
1966 299
1967 998
1968 1292
1969 1458
1970 1416
1971 1718
1972 2119
1973 2040
1974 1900
1975 2092
1976 2151
1977 2282
1978 2386
1979 2252
1980 2141
1981 2288
1982 2137
1983 2360
1984 2581
1985 2615
1986 2878
1987 3076
1988 3259
1989 3415
1990 3393
1991 3206
1992 3087
1993 3090
1994 3221
1995 2910
1996 3106
1997 3181
1998 3652
1999 3648
2000 4109
2001 4263
2002 4471
2003 4842
2004 5184
2005 5515
2006 5891
2007 5937
2008 5849
2009 6213
2010 5845
2011 5825
2012 5920
2013 5951
2014 5938
2015 5907
2016 5524
2017 5299
2018 4906
2019 1881
2020 41
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178,604 results
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Page 1
HEK293 cell line: a vehicle for the expression of recombinant proteins.
Thomas P and Smart TG. J Pharmacol Toxicol Methods 2005 - Review. PMID 15862464
The principal attributes which have made the HEK cell a popular choice among electrophysiologists to study isolated receptor channels include; its quick and easy reproduction and maintenance; amenability to transfection using a wide variety of methods; high efficiency of transfection and protein production; faithful translation and processing of proteins; and small cell size with minimal processes appropriate for voltage-clamp experimentation. These, and other attributes, also mean that complementary biochemical/cell biological evaluations of expressed proteins can be performed in concert with functional analyses to establish detailed pharmacological and biophysical profiles for the action of new drugs and their targets. ...
The principal attributes which have made the HEK cell a popular choice among electrophysiologists to study isolated receptor c …
Modifiers of membrane dipole potentials as tools for investigating ion channel formation and functioning.
Ostroumova OS, et al. Int Rev Cell Mol Biol 2015 - Review. PMID 25708465
The role of the membrane dipole potential is of particular interest because of its powerful impact on membrane permeability and lipid-protein interactions, including protein insertion, oligomerization, and function. ...As a result, the membrane interior is several hundred millivolts more positive than the external aqueous phase. This potential decrease depends on the lipid, and especially sterol, composition of the membrane. ...
The role of the membrane dipole potential is of particular interest because of its powerful impact on membran
Protonophoric action of triclosan causes calcium efflux from mitochondria, plasma membrane depolarization and bursts of miniature end-plate potentials.
Popova LB, et al. Biochim Biophys Acta Biomembr 2018. PMID 29317196 Free article.
Here, we for the first time report data on a high protonophoric activity of TCS on planar BLM. TCS proved to be a more effective protonophore on planar BLM, than classical uncouplers. ...Also similar to the action of common uncouplers, TCS caused a pronounced increase in frequency of miniature end-plate potentials at neuromuscular junctions. ...
Here, we for the first time report data on a high protonophoric activity of TCS on planar BLM. TCS proved to be a more …
Membrane potentials at zero current. The significance of a constant ionic permeability ratio.
Sandblom JP and Eisenman G. Biophys J 1967. PMID 6035122 Free PMC article.
The possibility has been examined that the Goldman-Hodgkin-Katz equation for V(0), the total membrane potential at zero current, can be derived with constant permeability ratios from a thermodynamic treatment. ...From these relationships it was possible to define the permeability ratio in terms of the thermodynamic properties of the membrane quite generally and to identify the permeability ratio as the product of mobility ratio and ratio of partition coefficients. ...
The possibility has been examined that the Goldman-Hodgkin-Katz equation for V(0), the total membrane potential at zero …
Effect of the use of a model with peer instruction for the teaching of membrane potential and action potential.
Albuquerque FDS, et al. Adv Physiol Educ 2018. PMID 30387701 Free article.
A group of teachers from Northeast Brazil developed a model of membrane potentials and action potential and tested the hypothesis that using the peer-instruction model would provide a better performance for students in reading traditional texts and lectures. ...At the end of the lecture, everyone responded to a posttest. Student performance in the pretest did not differ significantly between groups. ...
A group of teachers from Northeast Brazil developed a model of membrane potentials and action potential and tested the …
Membrane resistance and shunting inhibition: where biophysics meets state-dependent human neurophysiology.
Paulus W and Rothwell JC. J Physiol 2016 - Review. PMID 26940751 Free PMC article.
Activation of neurons not only changes their membrane potential and firing rate but as a secondary action reduces membrane resistance. ...Membrane conductance is also increased during shunting inhibition, which accompanies the classic GABAA IPSP. This short-circuits nearby EPSPs and is suggested here to contribute to the magnitude and time course of short-interval intracortical inhibition and intracortical facilitation....
Activation of neurons not only changes their membrane potential and firing rate but as a secondary action reduces membrane
Modeling of Electroporation Induced by Pulsed Electric Fields in Irregularly Shaped Cells.
Mescia L, et al. IEEE Trans Biomed Eng 2018. PMID 29346108
During the past decades, the poration of cell membrane induced by pulsed electric fields has been widely investigated. Since the basic mechanisms of this process have not yet been fully clarified, many research activities are focused on the development of suitable theoretical and numerical models. ...For each type of cell, the influence of the relevant shape, the dielectric properties, and the external electric pulse characteristics on the electroporation process has been analyzed. ...
During the past decades, the poration of cell membrane induced by pulsed electric fields has been widely investi …
Alternative Models to Hodgkin-Huxley Equations
Deng B. Bull Math Biol 2017. PMID 28500440
Firstly, it is only phenomenological not mechanistic. Secondly, it fails to exhibit the all-or-nothing firing mechanism for action potential generation. Thirdly, it lacks a theory for ion channel opening and closing activation across the cell membrane. Fourthly, it does not count for the phenomenon of voltage-gating which is vitally important for action potential generation. ...
Firstly, it is only phenomenological not mechanistic. Secondly, it fails to exhibit the all-or-nothing firing mechanism for action …
Actions of Neuropeptide Y on Synaptic Transmission in the Lateral Habenula
Cheon M, et al. Neuroscience 2019. Among authors: Park H. PMID 31082535
Neuropeptide Y is a peptide neuromodulator with protective roles including anxiolytic and antidepressant-like effects in animal models of depression and post-traumatic stress disorder. ...We observed that NPY inhibited excitatory neurotransmission in a subset of LHb neurons whereas potentiating in a small population of neurons. ...
Neuropeptide Y is a peptide neuromodulator with protective roles including anxiolytic and antidepressant-like effects in anima …
Electrophysiological effects of melatonin on rat trigeminal ganglion neurons that participate in nociception in vitro.
Huang F, et al. Eur Rev Med Pharmacol Sci 2018. PMID 29863270 Free article.
The neuron was voltage clamped using the whole cell patch clamp technique. We recorded resting membrane potential, action potential threshold and number, action potential duration and GABA-activated inward currents in the presence of 0.01 μM, 10 μM MT, and in the absence of MT. RESULTS: In the presence of high concentration of MT, the spontaneous action potential disappeared and action potential threshold was significantly increased. ...
The neuron was voltage clamped using the whole cell patch clamp technique. We recorded resting membrane potential, acti …
178,604 results
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