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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 25
1946 56
1947 71
1948 96
1949 93
1950 95
1951 98
1952 131
1953 145
1954 173
1955 192
1956 235
1957 227
1958 249
1959 238
1960 223
1961 320
1962 311
1963 703
1964 960
1965 730
1966 685
1967 944
1968 1045
1969 1164
1970 1206
1971 1443
1972 1735
1973 2258
1974 2835
1975 3216
1976 3693
1977 4662
1978 5698
1979 6938
1980 9067
1981 10135
1982 12155
1983 12949
1984 14905
1985 16676
1986 18029
1987 18902
1988 21421
1989 24005
1990 26795
1991 29122
1992 31714
1993 34822
1994 37369
1995 39260
1996 40960
1997 43390
1998 46071
1999 48069
2000 52046
2001 54324
2002 56124
2003 58980
2004 62254
2005 65909
2006 69800
2007 71810
2008 74028
2009 75949
2010 79063
2011 82841
2012 85896
2013 87360
2014 85608
2015 85251
2016 81621
2017 79479
2018 75707
2019 35408
2020 815
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1,845,577 results
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Page 1
Current strategies for protein production and purification enabling membrane protein structural biology.
Pandey A, et al. Biochem Cell Biol 2016 - Review. Among authors: Patterson RE. PMID 27010607 Free PMC article.
Membrane proteins are still heavily under-represented in the protein data bank (PDB), owing to multiple bottlenecks. The typical low abundance of membrane proteins in their natural hosts makes it necessary to overexpress these proteins either in heterologous systems or through in vitro translation/cell-free expression. ...Combined, these advances have made the past 10-15 years very exciting and eventful for the field of membrane protein structural biology, with an exponential growth in the number of solved membrane protein structures. ...
Membrane proteins are still heavily under-represented in the protein data bank (PDB), owing to multiple bottlene
Semisynthesis of Membrane-Attached Proteins Using Split Inteins.
Hackl S, et al. Methods Mol Biol 2017. PMID 27714612
The site-selective installation of lipid modifications on proteins is critically important in our understanding of how membrane association influences the biophysical properties of proteins as well as to study certain proteins in their native environment. ...A synthetic peptide carrying two lipid chains is also made chemically to serve as a membrane anchor and subsequently linked to the C-terminal split intein by native chemical ligation. ...
The site-selective installation of lipid modifications on proteins is critically important in our understanding of how membrane
Bioinformatics approaches for functional annotation of membrane proteins.
Gromiha MM and Ou YY. Brief Bioinform 2014 - Review. PMID 23524979
Membrane proteins perform diverse functions in living organisms such as transporters, receptors and channels. The functions of membrane proteins have been investigated with several computational approaches, such as developing databases, analyzing the structure-function relationship and establishing algorithms to discriminate different type of membrane proteins. ...In this comprehensive review, we elaborately focus on three aspects of membrane protein functions: (i) databases for different types of membrane proteins based on their functions including transporters, receptors and ion channels, annotated functional data for genomes, as well as functionally important amino acid residues in membrane proteins obtained from experimental data, (ii) analysis of membrane protein functions based on their structures, motifs, amino acid properties and other features and (iii) algorithms for discriminating different types of membrane proteins and annotating them in genomic sequences. ...
Membrane proteins perform diverse functions in living organisms such as transporters, receptors and channels. The funct
Mem-mEN: Predicting Multi-Functional Types of Membrane Proteins by Interpretable Elastic Nets.
Wan S, et al. IEEE/ACM Trans Comput Biol Bioinform 2016. PMID 26336143
Membrane proteins play important roles in various biological processes within organisms. Predicting the functional types of membrane proteins is indispensable to the characterization of membrane proteins. Recent studies have extended to predicting single- and multi-type membrane proteins. However, existing predictors perform poorly and more importantly, they are often lack of interpretability. ...
Membrane proteins play important roles in various biological processes within organisms. Predicting the f
A cascade of multiple proteins and lipids catalyzes membrane fusion.
Wickner W and Rizo J. Mol Biol Cell 2017 - Review. PMID 28292915 Free PMC article.
Recent studies suggest revisions to the SNARE paradigm of membrane fusion. Membrane tethers and/or SNAREs recruit proteins of the Sec 1/Munc18 family to catalyze SNARE assembly into trans-complexes. SNARE-domain zippering draws the bilayers into immediate apposition and provides a platform to position fusion triggers such as Sec 17/α-SNAP and/or synaptotagmin, which insert their apolar "wedge" domains into the bilayers, initiating the lipid rearrangements of fusion....
Recent studies suggest revisions to the SNARE paradigm of membrane fusion. Membrane tethers and/or SNAREs recruit pr
Cell surface membrane proteins as personalized biomarkers: where we stand and where we are headed.
Várady G, et al. Biomark Med 2013 - Review. PMID 24044572
Membrane proteins comprise approximately 30% of total human proteins; they play a key role in various physiological functions and pathological conditions, although, currently, only a limited number of membrane proteins are applied as biomarkers. In many normal tissues, cell surface membrane proteins are not easily accessible for diagnostic sampling, and tumor-derived membrane preparations - while serving as potential tumor biomarkers - may not reflect physiological protein expression. ...
Membrane proteins comprise approximately 30% of total human proteins; they play a key role in various physiol
A structural perspective on tail-anchored protein biogenesis by the GET pathway.
Mateja A and Keenan RJ. Curr Opin Struct Biol 2018 - Review. PMID 30173121 Free PMC article.
Many tail-anchored (TA) membrane proteins are targeted to and inserted into the endoplasmic reticulum (ER) by the `guided entry of tail-anchored proteins' (GET) pathway. This post-translational pathway uses transmembrane-domain selective cytosolic chaperones for targeting, and a dedicated membrane protein complex for insertion. ...
Many tail-anchored (TA) membrane proteins are targeted to and inserted into the endoplasmic reticulum (ER) by the `guided entr …
An introduction to membrane proteins.
Hedin LE, et al. J Proteome Res 2011 - Review. PMID 21815691
α-Helical membrane proteins are important for many biological functions. Due to physicochemical constraints, the structures of membrane proteins differ from the structure of soluble proteins. Historically, membrane protein structures were assumed to be more or less two-dimensional, consisting of long, straight, membrane-spanning parallel helices packed against each other. ...
α-Helical membrane proteins are important for many biological functions. Due to physicochemical constraints, the struct …
1,845,577 results
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