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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 10
1946 24
1947 33
1948 49
1949 50
1950 65
1951 87
1952 93
1953 115
1954 104
1955 117
1956 138
1957 131
1958 190
1959 191
1960 199
1961 221
1962 265
1963 343
1964 569
1965 628
1966 603
1967 824
1968 1000
1969 1062
1970 1085
1971 1121
1972 1141
1973 1114
1974 1070
1975 997
1976 948
1977 866
1978 824
1979 803
1980 755
1981 702
1982 702
1983 656
1984 754
1985 728
1986 661
1987 641
1988 670
1989 658
1990 719
1991 780
1992 734
1993 726
1994 850
1995 852
1996 900
1997 868
1998 927
1999 1110
2000 1867
2001 2426
2002 2678
2003 2613
2004 2793
2005 3044
2006 3252
2007 4077
2008 4316
2009 4725
2010 5481
2011 6854
2012 8780
2013 9315
2014 9716
2015 10205
2016 10279
2017 10161
2018 10463
2019 6012
2020 179
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137,351 results
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Page 1
Steady states and stability in metabolic networks without regulation.
Ivanov O, et al. J Theor Biol 2016. PMID 26992576
Metabolic networks are often extremely complex. Despite intensive efforts many details of these networks, e.g., exact kinetic rates and parameters of metabolic reactions, are not known, making it difficult to derive their properties. ...Specifically, metabolic networks with single-substrate-single-product reactions have disconnected steady states, whereas in metabolic networks with multiple-substrates-multiple-product reactions manifolds of steady states arise. ...
Metabolic networks are often extremely complex. Despite intensive efforts many details of these networks, e.g., exact kinetic rates a
Cooperative Instruction of Signaling and Metabolic Pathways on the Epigenetic Landscape.
Kim JA. Mol Cells 2018 - Review. PMID 29665673 Free PMC article.
Metabolic dynamics altered by these stimuli also affect the activity of epigenetic modifiers. Here, I review the current understanding of epigenetic regulation via signaling and metabolic pathways. In addition, I will discuss possible ways to achieve specificity of epigenetic modifications through the cooperation of stimuli-induced signal transduction and metabolic reprogramming....
Metabolic dynamics altered by these stimuli also affect the activity of epigenetic modifiers. Here, I review the current understandin
The MetaCyc database of metabolic pathways and enzymes and the BioCyc collection of pathway/genome databases.
Caspi R, et al. Nucleic Acids Res 2016. PMID 26527732 Free PMC article.
The MetaCyc database (MetaCyc.org) is a freely accessible comprehensive database describing metabolic pathways and enzymes from all domains of life. The majority of MetaCyc pathways are small-molecule metabolic pathways that have been experimentally determined. MetaCyc contains more than 2400 pathways derived from >46,000 publications, and is the largest curated collection of metabolic pathways. ...
The MetaCyc database (MetaCyc.org) is a freely accessible comprehensive database describing metabolic pathways and enzymes from all d …
The pentose phosphate pathway and cancer
Patra KC and Hay N. Trends Biochem Sci 2014 - Review. PMID 25037503 Free PMC article.
Metabolic Reprogramming of Immune Cells in Cancer Progression.
Biswas SK. Immunity 2015 - Review. PMID 26377897 Free article.
However, recent studies reveal that immune cells upon activation also show distinct metabolic changes that impact their immune functions. Such metabolic reprogramming and its functional effects are well known for cancer cells. Given that immune cells have emerged as crucial players in cancer progression, it is important to understand whether immune cells also undergo metabolic reprogramming in tumors and how this might affect their contribution in cancer progression. ...
However, recent studies reveal that immune cells upon activation also show distinct metabolic changes that impact their immune functi …
Combining inferred regulatory and reconstructed metabolic networks enhances phenotype prediction in yeast.
Wang Z, et al. PLoS Comput Biol 2017. PMID 28520713 Free PMC article.
Gene regulatory and metabolic network models have been used successfully in many organisms, but inherent differences between them make networks difficult to integrate. ...IDREAM consistently outperformed PROM using any of three popular yeast metabolic models and across three experimental growth conditions. ...
Gene regulatory and metabolic network models have been used successfully in many organisms, but inherent differences between them mak …
Methods and advances in metabolic flux analysis: a mini-review.
Antoniewicz MR. J Ind Microbiol Biotechnol 2015 - Review. PMID 25613286
Metabolic flux analysis (MFA) is one of the pillars of metabolic engineering. Over the past three decades, it has been widely used to quantify intracellular metabolic fluxes in both native (wild type) and engineered biological systems. ...In this mini-review, we discuss and classify the various methods of MFA that have been developed, which include stoichiometric MFA, (13)C metabolic flux analysis, isotopic non-stationary (13)C metabolic flux analysis, dynamic metabolic flux analysis, and (13)C dynamic metabolic flux analysis. ...
Metabolic flux analysis (MFA) is one of the pillars of metabolic engineering. Over the past three decades, it has been widely
137,351 results
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