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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1951 2
1953 1
1955 2
1958 1
1959 1
1962 3
1963 2
1964 4
1968 1
1969 1
1970 26
1971 197
1972 212
1973 223
1974 174
1975 142
1976 118
1977 101
1978 116
1979 135
1980 127
1981 153
1982 124
1983 176
1984 193
1985 210
1986 145
1987 145
1988 155
1989 141
1990 154
1991 136
1992 187
1993 161
1994 196
1995 217
1996 208
1997 192
1998 161
1999 171
2000 198
2001 253
2002 320
2003 356
2004 311
2005 284
2006 336
2007 342
2008 378
2009 378
2010 395
2011 392
2012 397
2013 459
2014 454
2015 428
2016 479
2017 492
2018 523
2019 289
2020 5
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11,528 results
Results by year
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Page 1
m6A facilitates hippocampus-dependent learning and memory through YTHDF1
Shi H, et al. Nature 2018. PMID 30401835 Free PMC article.
Re-expression of YTHDF1 in the hippocampus of adult Ythdf1-knockout mice rescues the behavioural and synaptic defects, whereas hippocampus-specific acute knockdown of Ythdf1 or Mettl3, which encodes the catalytic component of the m(6)A methyltransferase complex, recapitulates the hippocampal deficiency. ...
Re-expression of YTHDF1 in the hippocampus of adult Ythdf1-knockout mice rescues the behavioural and synaptic defects, whereas hippocampus-s …
Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionally
Huang H, et al. Nature 2019. PMID 30867593 Free PMC article.
Mechanistically, H3K36me3 is recognized and bound directly by METTL14, a crucial component of the m(6)A methyltransferase complex (MTC), which in turn facilitates the binding of the m(6)A MTC to adjacent RNA polymerase II, thereby delivering the m(6)A MTC to actively transcribed nascent RNAs to deposit m(6)A co-transcriptionally. ...
Mechanistically, H3K36me3 is recognized and bound directly by METTL14, a crucial component of the m(6)A methyltransferase complex (MT …
m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer
Liu J, et al. Nat Cell Biol 2018. PMID 30154548 Free PMC article.
To study the roles of m(6)A mRNA methylation in cell proliferation and tumorigenicity, we investigated human endometrial cancer in which a hotspot R298P mutation is present in a key component of the methyltransferase complex (METTL14). We found that about 70% of endometrial tumours exhibit reductions in m(6)A methylation that are probably due to either this METTL14 mutation or reduced expression of METTL3, another component of the methyltransferase complex. ...
To study the roles of m(6)A mRNA methylation in cell proliferation and tumorigenicity, we investigated human endometrial cancer in which a h …
Eukaryotic 5-methylcytosine (m⁵C) RNA Methyltransferases: Mechanisms, Cellular Functions, and Links to Disease.
Bohnsack KE, et al. Genes (Basel) 2019 - Review. PMID 30704115 Free PMC article.
In eukaryotes, C5 methylation of RNA cytosines is catalyzed by enzymes of the NOL1/NOP2/SUN domain (NSUN) family, as well as the DNA methyltransferase homologue DNMT2. ...Importantly, this knowledge has enabled a better understanding of the molecular basis of a number of diseases caused by mutations in the genes encoding m⁵C methyltransferases or changes in the expression level of these enzymes....
In eukaryotes, C5 methylation of RNA cytosines is catalyzed by enzymes of the NOL1/NOP2/SUN domain (NSUN) family, as well as the DNA meth
Single-cell mapping of lineage and identity in direct reprogramming
Biddy BA, et al. Nature 2018. PMID 30518857 Free PMC article.
We find that expression of a putative methyltransferase, Mettl7a1, is associated with the successful reprogramming trajectory; adding Mettl7a1 to the reprogramming cocktail increases the yield of induced endoderm progenitors. ...
We find that expression of a putative methyltransferase, Mettl7a1, is associated with the successful reprogramming trajectory; adding …
The Critical Role of RNA m6A Methylation in Cancer
Lan Q, et al. Cancer Res 2019 - Review. PMID 30894375
Although RNA methyltransferase inhibitors are not available yet, FTO inhibitors have shown promising anticancer effects in vitro and in animal models of cancer. Further screening for selective and potent RNA methyltransferase, demethylase, or m(6)A-binding protein inhibitors may lead to compounds suitable for future clinical trials in cancer patients....
Although RNA methyltransferase inhibitors are not available yet, FTO inhibitors have shown promising anticancer effects in vitro and …
Mettl3-mediated m6A RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis
Wu Y, et al. Nat Commun 2018. PMID 30429466 Free PMC article.
Here we show that conditional knockout of the m(6)A methyltransferase Mettl3 in bone marrow mesenchymal stem cells (MSCs) induces pathological features of osteoporosis in mice. ...
Here we show that conditional knockout of the m(6)A methyltransferase Mettl3 in bone marrow mesenchymal stem cells (MSCs) induces pat …
11,528 results
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