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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1952 1
1953 4
1954 5
1955 5
1956 4
1957 2
1958 3
1959 6
1960 2
1961 8
1962 9
1963 14
1964 22
1965 9
1966 4
1967 7
1968 1
1970 31
1971 19
1972 300
1973 825
1974 929
1975 986
1976 910
1977 991
1978 961
1979 1107
1980 1231
1981 1607
1982 1847
1983 1715
1984 1815
1985 1866
1986 1694
1987 1717
1988 1864
1989 2040
1990 1880
1991 1956
1992 2184
1993 2763
1994 3079
1995 3316
1996 3526
1997 3732
1998 4191
1999 4605
2000 5437
2001 5674
2002 6398
2003 7019
2004 7672
2005 8605
2006 10015
2007 10825
2008 11884
2009 12995
2010 14956
2011 16054
2012 17121
2013 17704
2014 18312
2015 18932
2016 18854
2017 18983
2018 19860
2019 8117
2020 143
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280,801 results
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Page 1
Responses of Male C57BL/6N Mice to Observing the Euthanasia of Other Mice.
Boivin GP, et al. J Am Assoc Lab Anim Sci 2016. PMID 27423146 Free PMC article.
To determine if mice are a sensitive species we reviewed literature on empathy in mice, and measured the cardiovascular and activity response of mice observing euthanasia of conspecifics. We studied male 16-wk-old C57BL/6N mice and found no increase in cardiovascular parameters or activity in the response of the mice to observing CO2 euthanasia. ...
To determine if mice are a sensitive species we reviewed literature on empathy in mice, and measured the cardiovascular and ac …
What's in a (Sub)strain?
Goldstein JM and Wagers AJ. Stem Cell Reports 2018. PMID 30110622 Free PMC article.
C57BL/6J and C57BL/6N inbred mice are widely, and often interchangeably, used for stem cell research; yet, these substrains harbor discrete genetic differences that can cause phenotypic disparities. In this issue of Stem Cell Reports, Morales-Hernández et al. identify one particular difference-disruption of Nicotinamide Nucleotide Transhydrogenase (Nnt)-that increases reactive oxygen exposure and impairs hematopoietic progenitor cell function in C57BL/6J, as compared to C57BL/6N, mice....
C57BL/6J and C57BL/6N inbred mice are widely, and often interchangeably, used for stem cell research; yet, these substrains ha …
Body temperature of C57BL/6J mice with age.
Talan M. Exp Gerontol 1984. PMID 6723816
On the basis of a study of rectal temperature in a group of 180, C57BL/6J male mice, ranging in age from 3 months to 30 months, the following conclusions were drawn: 1) The positive correlation between body weight and body temperature typical for rodents was found only for young adults of the C57BL/6J strain; 2) body temperature of male C57BL/6J did not appear to decline until about 23.5 months, after which there was a significant negative correlation (r = -0.53) between age and temperature....
On the basis of a study of rectal temperature in a group of 180, C57BL/6J male mice, ranging in age from 3 months to 30 months, the f …
Genetic differences among C57BL/6 substrains
Mekada K, et al. Exp Anim 2009. PMID 19448337 Free article.
The C57BL/6 mouse is the most well-known inbred mouse strain, and has been widely used as a genetic background for congenic and mutant mice. ...These data will be useful for accurate genetic monitoring of genetically engineered mice with the C57BL/6 background....
The C57BL/6 mouse is the most well-known inbred mouse strain, and has been widely used as a genetic background for congenic and mutan …
Clinical Chemistry Reference Intervals for C57BL/6J, C57BL/6N, and C3HeB/FeJ Mice (Mus musculus).
Otto GP, et al. J Am Assoc Lab Anim Sci 2016. PMID 27423143 Free PMC article.
Although various mouse inbred strains are widely used to investigate disease mechanisms and to establish new therapeutic strategies, sex-specific reference intervals for laboratory diagnostic analytes that are generated from large numbers of animals have been unavailable. ...In addition, we include an overview of the literature that reports clinical chemistry values for wild-type mice of different strains. ...
Although various mouse inbred strains are widely used to investigate disease mechanisms and to establish new therapeutic strategies, …
Postnatal Development of the Craniofacial Skeleton in Male C57BL/6J Mice.
Maga AM. J Am Assoc Lab Anim Sci 2016. PMID 27025802 Free PMC article.
C57BL/6J is one of the most commonly used inbred mouse strains in biomedical research, including studies of craniofacial development and teratogenic studies of craniofacial malformation. The current study quantitatively assessed the development of the skull in male C57BL/6J mice by using high-resolution 3D imaging of 55 landmarks from 48 male mice over 10 developmental time points from postnatal day 0 to 90. ...
C57BL/6J is one of the most commonly used inbred mouse strains in biomedical research, including studies of craniofacial development …
Socially dominant mice in C57BL6 background show increased social motivation.
Kunkel T and Wang H. Behav Brain Res 2018. PMID 28859999 Free PMC article.
Mice with top and bottom social ranks are subjected to a three-chamber social interaction test to measure social motivation. The top ranked mice spend more time interacting with a stranger mouse than the bottom ranked mice, suggesting that social dominance may positively influence social motivation. ...
Mice with top and bottom social ranks are subjected to a three-chamber social interaction test to measure social motivation. The top
Unusual anatomical origins of the coronary arteries in C57BL/6 mice. Are they strain-specific?
López-García A, et al. J Anat 2016. PMID 27345017 Free PMC article.
The aim here was to elucidate whether this pattern is unique to C57BL/6 mice or appears in other laboratory mouse strains and in wild-living mice. Stereomicroscopy, scanning electron microscopy, light microscopy and a corrosion cast technique were used to examine 597 adult mice belonging to three inbred strains (C57BL/6, Balb/c, DBA/2), three outbred stocks (CD1, OF1, NMRI) two hybrid lines (129sv × BL/6, CD2F1) and wild mice. ...
The aim here was to elucidate whether this pattern is unique to C57BL/6 mice or appears in other laboratory mouse strains and in wild …
Behavioural characterization of C57BL/6N and BALB/c female mice in social home cage - Effect of mixed housing in complex environment.
Heinla I, et al. Physiol Behav 2018. PMID 29382562 Free article.
Mixing of two strains resulted in reduction of body weight and anhedonia in B6 mice. In addition, the B6 mice showed clear preference to previous home-cage, and formed a new home-base faster than BALB mice. In contrast, BALB mice showed enhanced activity and moving between the cages without showing any preference to previous home-cage. ...
Mixing of two strains resulted in reduction of body weight and anhedonia in B6 mice. In addition, the B6 mice showed clear pre …
Experiments done in Black-6 mice: what does it mean?
Åhlgren J and Voikar V. Lab Anim (NY) 2019. PMID 31011223
Attempts to enhance the replicability and to reduce the variability in basic research has led to the recommendation to use isogenic mice. ...However, C57BL/6 mice are maintained as substrains by multiple vendors. Evidence exists that the subtle differences between these mouse lines have not been systematically investigated and are often ignored. ...
Attempts to enhance the replicability and to reduce the variability in basic research has led to the recommendation to use isogenic mice
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