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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1951 3
1952 2
1953 3
1954 4
1955 5
1956 11
1957 4
1958 5
1959 12
1960 6
1961 12
1962 19
1963 13
1964 15
1965 5
1971 4
1973 1
1974 17
1975 257
1976 309
1977 379
1978 459
1979 612
1980 708
1981 796
1982 883
1983 908
1984 1093
1985 1058
1986 1138
1987 1173
1988 1330
1989 1398
1990 1423
1991 1589
1992 1685
1993 1967
1994 2429
1995 2818
1996 3359
1997 3836
1998 4492
1999 5334
2000 6255
2001 6980
2002 7568
2003 8015
2004 8896
2005 9739
2006 10913
2007 11762
2008 12548
2009 13436
2010 14808
2011 16102
2012 16547
2013 16467
2014 16871
2015 16999
2016 16265
2017 15426
2018 15844
2019 5979
2020 66
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261,720 results
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Page 1
Creation of mutant mice with megabase-sized deletions containing custom-designed breakpoints by means of the CRISPR/Cas9 system.
Kato T, et al. Sci Rep 2017. PMID 28246396 Free PMC article.
So far, mutant mice with deletions of up to 1.2 megabases (Mb) have been generated by microinjection of the CRISPR/Cas9 system into fertilized eggs; however, a method for generation of mutant mice with a deletion of more than several Mb size is necessary because such deletions have often been identified as possible causes of human diseases. ...Using this method, we efficiently and rapidly generated mutant mice carrying deletions up to 5 Mb....
So far, mutant mice with deletions of up to 1.2 megabases (Mb) have been generated by microinjection of the CRISPR/Cas9 system …
Evaluating mutant mice: anatomic pathology.
Brayton C, et al. Vet Pathol 2001 - Review. PMID 11199155
Consequently, biomedical research institutions have seen significant increases in the use of mice since the early 1980s, and these increases are largely attributable to the use of genetically modified mice. The role of comparative pathology in research on mutant mouse models of disease is increasing in response to these trends. Evaluation and phenotypic characterization of mutant mice, via clinical and anatomic pathology techniques, will be an important component of functional genomics initiatives....
Consequently, biomedical research institutions have seen significant increases in the use of mice since the early 1980s, and these in …
Cognitive assessment of mice strains heterozygous for cell-adhesion genes reveals strain-specific alterations in timing.
Gallistel CR, et al. Philos Trans R Soc Lond B Biol Sci 2014. PMID 24446498 Free PMC article.
We used a fully automated system for the behavioural measurement of physiologically meaningful properties of basic mechanisms of cognition to test two strains of heterozygous mutant mice, Bfc (batface) and L1, and their wild-type littermate controls. ...These effects are functionally specific, because many other measures made on the same mice are unaffected, namely: the accuracy of matching temporal investment ratios to income ratios in a matching protocol, the rate of instrumental and classical conditioning, the latency to initiate a cued instrumental response, the trials on task and the impulsivity in a switch paradigm, the accuracy with which mice adjust timed switches to changes in the temporal constraints, the days to acquisition, and mean onset time and onset variability in the circadian anticipation of food availability....
We used a fully automated system for the behavioural measurement of physiologically meaningful properties of basic mechanisms of cognition t …
Spontaneous behavior in the social homecage discriminates strains, lesions and mutations in mice.
Vannoni E, et al. J Neurosci Methods 2014. PMID 24792526
COMPARISON WITH EXISTING METHODS: Monitoring of mutant mice with known deficits in hippocampus-dependent tests produced profiles very similar to those of hippocampally lesioned mice. CONCLUSIONS: Taken together, our results suggest that already the monitoring of spontaneous behavior during a week of free adaptation in the IntelliCage can contribute significantly to high throughput prescreening of mutant mice....
COMPARISON WITH EXISTING METHODS: Monitoring of mutant mice with known deficits in hippocampus-dependent tests produced profil …
In the name of reproducibility
Mallapaty S. Lab Anim (NY) 2018. PMID 29942069
A phenotype survey of 36 mutant mouse strains with gene-targeted defects in glycosyltransferases or glycan-binding proteins.
Orr SL, et al. Glycobiology 2013. PMID 23118208 Free PMC article.
The CFG constructed 16 new homozygous mutant mouse strains and completed the initial phenotype screen of the majority of these new mutant strains. ...Phenotype differences include abnormal testis morphology in GlcNAcT9- and Siglec-H-deficient mice and lethality in Pomgnt1-deficient mice. ...
The CFG constructed 16 new homozygous mutant mouse strains and completed the initial phenotype screen of the majority of these …
Mice made easy.
Cohen J. Science 2016. PMID 27811248
The p53-deficient mouse: a model for basic and applied cancer studies
Donehower LA. Semin Cancer Biol 1996 - Review. PMID 9110404
Null (p53-/-) mice have an average time to tumor development of 4.5 months, while half of the heterozygous (p53+/-) mice develop tumors by 18 months. The p53-deficient mice have been particularly valuable in examining the effects of p53 loss on tumor progression. In addition, the mice hold significant promise as tools to assess carcinogens, teratogens, chemopreventative agents, and cancer therapeutic regimens....
Null (p53-/-) mice have an average time to tumor development of 4.5 months, while half of the heterozygous (p53+/-) mice devel …
Mutant laboratory mice with abnormalities in pigmentation: annotated tables.
Nakamura M, et al. J Dermatol Sci 2002 - Review. PMID 11916127
Numerous transgenic, targeted mutagenesis (so-called 'knockouts'), conditional (so-called 'gene switch') and spontaneous mutant mice develop abnormal coat color phenotypes. ...Since defined abnormalities in such mutant mice provide important clues to the as yet often poorly understood functional roles of many gene products, this overview includes a corresponding, annotated table of mutant mice with pigmentation alterations. ...
Numerous transgenic, targeted mutagenesis (so-called 'knockouts'), conditional (so-called 'gene switch') and spontaneous mutant mi
261,720 results
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