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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1948 1
1966 2
1967 4
1968 1
1973 4
1974 39
1975 92
1976 66
1977 80
1978 63
1979 109
1980 123
1981 114
1982 112
1983 97
1984 80
1985 89
1986 97
1987 85
1988 158
1989 163
1990 95
1991 131
1992 142
1993 131
1994 130
1995 106
1996 108
1997 136
1998 126
1999 118
2000 120
2001 119
2002 120
2003 174
2004 219
2005 194
2006 269
2007 332
2008 320
2009 321
2010 441
2011 388
2012 346
2013 363
2014 367
2015 363
2016 354
2017 436
2018 405
2019 134
2020 2
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7,962 results
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Page 1
How cryo-electron microscopy and X-ray crystallography complement each other.
Wang HW and Wang JW. Protein Sci 2017 - Review. PMID 27543495 Free PMC article.
While the two methods are different in many respects, from sample preparation to structure determination, they both have the power to solve macromolecular structures at atomic resolution. It is important to understand the unique advantages and caveats of the two methods in solving structures and to appreciate the complementary nature of the two methods in structural biology. ...
While the two methods are different in many respects, from sample preparation to structure determination, they both have the power to …
Detection and Characterization of Extracellular Vesicles by Transmission and Cryo-Transmission Electron Microscopy.
Cizmar P and Yuana Y. Methods Mol Biol 2017. PMID 28828660
Transmission electron microscopy (TEM) and transmission scanning electron Microscopy (TSEM), which denotes application of a scanning electron microscope (SEM) in the transmission mode, have been used to detect and characterize particles down to an imaging resolution of ~1 nm. ...
Transmission electron microscopy (TEM) and transmission scanning electron Microscopy (TSEM), which denotes appli …
Quantitative Cryo-Scanning Transmission Electron Microscopy of Biological Materials.
Elbaum M. Adv Mater 2018 - Review. PMID 29748979
Cryo-microscopy is challenging, however, because of the sensitivity to electron irradiation and due to the weak electron scattering of organic material. ...Tomographic imaging is typically performed in wide-field transmission electron microscopy (TEM) mode with phase contrast generated by defocus. ...
Cryo-microscopy is challenging, however, because of the sensitivity to electron irradiation and due to the weak electron
Low-temperature electron microscopy: techniques and protocols.
Fleck RA. Methods Mol Biol 2015. PMID 25428009
As applied to both scanning and transmission electron microscopy, cryo-electron microscopy is a strategy whereby the application of low-temperature techniques are used to reduce or remove processing artifacts which are commonly encountered in more conventional room temperature electron microscopy techniques which rely heavily on chemical fixation and heavy metal staining. Often, cryo-electron microscopy allows direct observation of specimens, which have not been stained or chemically fixed....
As applied to both scanning and transmission electron microscopy, cryo-electron microscopy is a strategy whereby …
The genetic encoded toolbox for electron microscopy and connectomics.
Shigemoto R and Joesch M. Wiley Interdiscip Rev Dev Biol 2017 - Review. PMID 28800674
Developments in bioengineering and molecular biology have introduced a palette of genetically encoded probes for identification of specific cell populations in electron microscopy. ...These genetic encoded tags for electron microscopy promise to simplify the analysis of circuit motifs and become a central tool for structure-function studies of synaptic connections in the brain. ...
Developments in bioengineering and molecular biology have introduced a palette of genetically encoded probes for identification of specific …
Cryo-electron microscopy--a primer for the non-microscopist.
Milne JL, et al. FEBS J 2013 - Review. PMID 23181775 Free PMC article.
Cryo-electron microscopy (cryo-EM) is increasingly becoming a mainstream technology for studying the architecture of cells, viruses and protein assemblies at molecular resolution. ...We discuss the ways in which these methods are being used to study structures of macromolecular assemblies that range in size from whole cells to small proteins. ...
Cryo-electron microscopy (cryo-EM) is increasingly becoming a mainstream technology for studying the architecture of cells, vi …
Introduction to high-resolution cryo-electron microscopy.
Czarnocki-Cieciura M and Nowotny M. Postepy Biochem 2016 - Review. PMID 28132494 Free article.
Traditional cryo-electron microscopy of biological macromolecules produced macromolecular reconstructions at resolution limited to 6-10 Å. ...Thus, cryo-EM is now becoming the method of choice for structural analysis of many complex assemblies that are unsuitable for structure determination by other methods....
Traditional cryo-electron microscopy of biological macromolecules produced macromolecular reconstructions at resolution limite …
Cryogenic electron microscopy and single-particle analysis.
Elmlund D and Elmlund H. Annu Rev Biochem 2015 - Review. PMID 25747402
About 20 years ago, the first three-dimensional (3D) reconstructions at subnanometer (<10-Å) resolution of an icosahedral virus assembly were obtained by cryogenic electron microscopy (cryo-EM) and single-particle analysis. ...Almost overnight, the recent development of direct electron detectors and the attendant improvement in analysis software have advanced the technology considerably. ...
About 20 years ago, the first three-dimensional (3D) reconstructions at subnanometer (<10-Å) resolution of an icosahedral virus assembly …
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