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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1956 1
1979 2
1980 10
1981 50
1982 53
1983 101
1984 75
1985 78
1986 105
1987 156
1988 160
1989 199
1990 247
1991 237
1992 228
1993 281
1994 253
1995 233
1996 235
1997 219
1998 210
1999 272
2000 231
2001 251
2002 241
2003 247
2004 277
2005 287
2006 309
2007 316
2008 312
2009 341
2010 327
2011 321
2012 330
2013 353
2014 344
2015 351
2016 308
2017 337
2018 279
2019 143
2020 6
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8,717 results
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Page 1
Midazolam as a first-line treatment for neonatal seizures: Retrospective study.
Dao K, et al. Pediatr Int 2018. PMID 29878631
We retrospectively studied the tolerability of midazolam in 72 newborn infants who received i.v. or i.n. midazolam as first-line treatment for seizures. No major side-effect exclusively due to midazolam was reported. The i.n. route was used for 20 patients (27.8%). Effectiveness could not be formally evaluated due to the absence of systematic electroencephalogram recording while midazolam was administered. ...
We retrospectively studied the tolerability of midazolam in 72 newborn infants who received i.v. or i.n. midazolam as first-li …
Population pharmacodynamic modelling of midazolam induced sedation in terminally ill adult patients.
Franken LG, et al. Br J Clin Pharmacol 2018. PMID 28960387 Free PMC article.
RESULTS: The effect of midazolam on the sedation level was best described by a differential odds model including a baseline probability, Emax model and interindividual variability on the overall effect. ...CONCLUSION: We were able to describe the clinical response to midazolam accurately. As expected, there was large variability in response to midazolam. ...
RESULTS: The effect of midazolam on the sedation level was best described by a differential odds model including a baseline probabili …
Comparison of oral dexmedetomidine and midazolam for premedication and emergence delirium in children after dental procedures under general anesthesia: a retrospective study.
Keles S and Kocaturk O. Drug Des Devel Ther 2018. PMID 29636599 Free PMC article.
The aim of this study was to compare the effect of oral dexmedetomidine (DEX) and oral midazolam (MID) on preoperative cooperation and emergence delirium (ED) among children who underwent dental procedures at our hospital between 2016 and 2017. ...
The aim of this study was to compare the effect of oral dexmedetomidine (DEX) and oral midazolam (MID) on preoperative cooperation an …
Hypoalbuminaemia and decreased midazolam clearance in terminally ill adult patients, an inflammatory effect?
Franken LG, et al. Br J Clin Pharmacol 2017 - Clinical Trial. PMID 28177137 Free PMC article.
To find clinically relevant parameters for dose individualization, we performed a pharmacokinetic study on midazolam, 1OH-midazolam (1-OH-M) and 1OH-midazolam-glucuronide (1-OH-MG) in terminally ill patients. ...In addition, low albumin levels were associated with decreased midazolam clearance, explaining 18.2% of the IIV. CONCLUSION: Our study indicates albumin levels and eGFR as relevant clinical parameters to optimize midazolam dosing in terminally ill patients. ...
To find clinically relevant parameters for dose individualization, we performed a pharmacokinetic study on midazolam, 1OH-midazola
Implementation of Intranasal Midazolam for Prolonged Seizures in a Child Neurology Practice.
Crawford D. J Neurosci Nurs 2016. PMID 27602530
Currently, evidence supports the use of intranasal midazolam as an effective, and in many cases, preferable treatment option for prolonged seizures in children. ...Provider surveys analyzed provider attitudes toward intranasal midazolam and its frequency of use. Because of this project, a dramatic increase in the prescribing of intranasal midazolam was observed within a child neurology practice....
Currently, evidence supports the use of intranasal midazolam as an effective, and in many cases, preferable treatment option for prol …
Potential for Drug Repositioning of Midazolam for Dentin Regeneration.
Karakida T, et al. Int J Mol Sci 2019. PMID 30720745 Free PMC article.
An induction of the anesthetic and sedative drug; midazolam (MDZ), regulatesinhibitory neurotransmitters in the vertebrate nervous system. ...
An induction of the anesthetic and sedative drug; midazolam (MDZ), regulatesinhibitory neurotransmitters in the vertebrate nervous sy …
Intranasal Midazolam Sedation in a Pediatric Emergency Dental Clinic.
Peerbhay F and Elsheikhomer AM. Anesth Prog 2016 - Clinical Trial. PMID 27585415 Free PMC article.
The purpose of this study was to compare the effectiveness and recovery times of 0.3 and 0.5 mg/kg intranasal midazolam (INM) administered with a mucosal atomizer device (MAD) in a pediatric emergency dental hospital clinic. ...
The purpose of this study was to compare the effectiveness and recovery times of 0.3 and 0.5 mg/kg intranasal midazolam (INM) adminis …
The safety and tolerability of intranasal midazolam in epilepsy.
Mula M. Expert Rev Neurother 2014 - Review. PMID 24910118
This article aims to provide an overview of intranasal midazolam in the acute management of epileptic seizures. Available data suggest that midazolam 0.2 mg/kg is as effective as diazepam 0.5 mg/kg, especially in children with febrile or afebrile seizures. ...Moreover, comparisons with buccal midazolam are warranted....
This article aims to provide an overview of intranasal midazolam in the acute management of epileptic seizures. Available data sugges …
Pharmacokinetics, pharmacodynamics, and tolerability of USL261, midazolam nasal spray: Randomized study in healthy geriatric and non-geriatric adults.
Berg AK, et al. Epilepsy Behav 2017 - Clinical Trial. PMID 28544992 Free article.
CONCLUSIONS: Despite increased midazolam exposure in geriatric subjects, there were no differences between age groups in pharmacodynamic effects or adverse event rates. ...Overall, pharmacokinetic findings for USL261 were similar to studies evaluating intravenous midazolam, whereas pharmacodynamic effects were less pronounced in the elderly than previously reported....
CONCLUSIONS: Despite increased midazolam exposure in geriatric subjects, there were no differences between age groups in pharmacodyna …
The Prediction of the Area under the Curve and Clearance of Midazolam from Single-Point Plasma Concentration and Urinary Excretion in Healthy Volunteers.
Miura M, et al. Biol Pharm Bull 2019 - Clinical Trial. PMID 31474719 Free article.
To determine the area under the curve (AUC) of midazolam or midazolam clearance for CYP3A4 activity, multiple plasma samples of midazolam are required. This study aimed to evaluate whether measurement of a single plasma concentration or urinary excretion of midazolam could be used to predict the AUC of midazolam in healthy volunteers. ...
To determine the area under the curve (AUC) of midazolam or midazolam clearance for CYP3A4 activity, multiple plasma samples o …
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