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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1952 2
1953 3
1954 2
1956 3
1957 14
1958 10
1959 9
1964 11
1965 41
1966 108
1967 164
1968 210
1969 272
1970 332
1971 454
1972 516
1973 588
1974 560
1975 510
1976 434
1977 423
1978 336
1979 390
1980 365
1981 295
1982 310
1983 288
1984 286
1985 279
1986 309
1987 311
1988 340
1989 408
1990 380
1991 407
1992 382
1993 378
1994 388
1995 376
1996 381
1997 423
1998 467
1999 522
2000 649
2001 751
2002 801
2003 875
2004 938
2005 1088
2006 1003
2007 1203
2008 1280
2009 1363
2010 1475
2011 1520
2012 1724
2013 1935
2014 1893
2015 2034
2016 2117
2017 2242
2018 2210
2019 1103
2020 24
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37,385 results
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Page 1
Mitochondria as a therapeutic target for common pathologies.
Murphy MP and Hartley RC. Nat Rev Drug Discov 2018 - Review. PMID 30393373
Although the development of mitochondrial therapies has largely focused on diseases caused by mutations in mitochondrial DNA or in nuclear genes encoding mitochondrial proteins, it has been found that mitochondrial dysfunction also contributes to the pathology of many common disorders, including neurodegeneration, metabolic disease, heart failure, ischaemia-reperfusion injury and protozoal infections. Mitochondria therefore represent an important drug target for these highly prevalent diseases. Several strategies aimed at therapeutically restoring mitochondrial function are emerging, and a small number of agents have entered clinical trials. ...
Although the development of mitochondrial therapies has largely focused on diseases caused by mutations in mitochondrial DNA o …
Protective Effects of Melatonin and Mitochondria-targeted Antioxidants Against Oxidative Stress: A Review.
Ramis MR, et al. Curr Med Chem 2015 - Review. PMID 26087763
The resulting deleterious effects of the damage to mitochondria can be prevented by antioxidants. Melatonin is an endogenously-produced indoleamine that modulates numerous functions, including mitochondria-related functions; this result from its capacity to penetrate all morphophysiological barriers and to enter all subcellular compartments due to its amphiphilic nature. ...Mitochondria-targeted antioxidants accumulate in several hundred-fold greater concentrations within mitochondria and protect these critical organelles from oxidative damage. ...
The resulting deleterious effects of the damage to mitochondria can be prevented by antioxidants. Melatonin is an endogenously …
Toxicity of Antiepileptic Drugs to Mitochondria.
Finsterer J. Handb Exp Pharmacol 2017 - Review. PMID 27590225
Some of the side and beneficial effects of antiepileptic drugs (AEDs) are mediated via the influence on mitochondria. This is of particular importance in patients requiring AED treatment for mitochondrial epilepsy. ...In the majority of the AEDs, however, information about their influence of mitochondria is lacking. In clinical practice mitochondrial epilepsy should be initially treated with AEDs with low mitochondrion-toxic potential. ...
Some of the side and beneficial effects of antiepileptic drugs (AEDs) are mediated via the influence on mitochondria. This is …
Mitochondrial Biogenesis as a Pharmacological Target: A New Approach to Acute and Chronic Diseases.
Whitaker RM, et al. Annu Rev Pharmacol Toxicol 2016 - Review. PMID 26566156
Mitochondrial dysfunction is a key pathophysiological component of many acute and chronic diseases. Maintenance of mitochondrial homeostasis through the balance of mitochondrial turnover, fission and fusion, and generation of new mitochondria via mitochondrial biogenesis is critical for tissue health. ...This review provides an overview of the role of mitochondrial dysfunction in acute and chronic diseases, details the current state of therapeutics for the stimulation of mitochondrial biogenesis and their effects on disease outcomes, describes new screening methodologies to identify novel stimulators and noncanonical pathways of mitochondrial biogenesis, and discusses potential hurdles of mitochondrial biogenesis as a therapeutic strategy....
Mitochondrial dysfunction is a key pathophysiological component of many acute and chronic diseases. Maintenance of mitochondrial
Pharmacological targeting of mitochondria in cancer stem cells: An ancient organelle at the crossroad of novel anti-cancer therapies.
Skoda J, et al. Pharmacol Res 2019 - Review. PMID 30453033
Mitochondria play vital roles in various cellular processes, ranging from cellular metabolism to signal transduction and cell death regulation. As these properties are critical for cancer growth, the mitochondrion has recently become an attractive target for anti-cancer therapies. ...
Mitochondria play vital roles in various cellular processes, ranging from cellular metabolism to signal transduction and cell death r
Drug induced mitochondrial dysfunction: Mechanisms and adverse clinical consequences.
Vuda M and Kamath A. Mitochondrion 2016 - Review. PMID 27771494
Several commonly used medications impair mitochondrial function resulting in adverse effects or toxicities. Drug induced mitochondrial dysfunction may be a consequence of increased production of reactive oxygen species, altered mitochondrial permeability transition, impaired mitochondrial respiration, mitochondrial DNA damage or inhibition of beta-oxidation of fatty acids. The clinical manifestation depends on the specific drug and its effect on mitochondria. Given the ubiquitous presence of mitochondria and its central role in cellular metabolism, drug-mitochondrial interactions may manifest clinically as hepatotoxicity, enteropathy, myelosuppression, lipodystrophy syndrome or neuropsychiatric adverse effects, to name a few. ...
Several commonly used medications impair mitochondrial function resulting in adverse effects or toxicities. Drug induce …
Aiming for the target: Mitochondrial drug delivery in traumatic brain injury.
Lamade AM, et al. Neuropharmacology 2019 - Review. PMID 30009835 Free PMC article.
Mitochondrial drug localization is accomplished using (1) the mitochondrial membrane potential, (2) affinity of a carrier to mitochondria-specific components (e.g. lipids), (3) piggybacking on the cells own mitochondria trafficking systems, or (4) nanoparticle-based approaches. In this review, we briefly consider the mitochondrial delivery strategies and drug targets that illustrate the promise of these mitochondria-specific approaches in the design of TBI pharmacotherapy. ...
Mitochondrial drug localization is accomplished using (1) the mitochondrial membrane potential, (2) affinity of a carri
[Research progress on regulation effect of Panax notoginseng saponins on mitochondria].
Yang ZP and Bao YM. Zhongguo Zhong Yao Za Zhi 2017 - Review. PMID 28994528 Chinese.
Mitochondria is the key energy source of cells and plays an important role in energy synthesis and release, and maintenance of cellular functions. ...Therefore, the mitochondria is one of the important targets of PNS. In this paper, the regulation effects of P. notoginseng saponins on mitochondria were reviewed....
Mitochondria is the key energy source of cells and plays an important role in energy synthesis and release, and maintenance of cellul
Propofol Related Infusion Syndrome: Ultrastructural Evidence for a Mitochondrial Disorder.
Vollmer JP, et al. Crit Care Med 2018. PMID 29252954
Electron microscopy revealed dark, electron dense amorphous structures associated with mitochondria in heart muscle and liver tissue obtained at autopsy. ...CONCLUSIONS: Electron dense bodies found in association with mitochondria in muscle and liver cells probably correspond to accumulation of free fatty acid provide direct morphological evidence for the mitochondrial damage in propofol-related infusion syndrome....
Electron microscopy revealed dark, electron dense amorphous structures associated with mitochondria in heart muscle and liver tissue …
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