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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1954 1
1956 1
1957 1
1959 1
1960 1
1961 2
1962 1
1963 2
1964 7
1965 4
1968 1
1974 1
1977 2
1980 2
1981 10
1982 5
1983 13
1984 20
1985 30
1986 33
1987 36
1988 36
1989 44
1990 49
1991 46
1992 53
1993 74
1994 98
1995 97
1996 127
1997 141
1998 255
1999 280
2000 313
2001 425
2002 570
2003 635
2004 756
2005 789
2006 869
2007 970
2008 1063
2009 1170
2010 1212
2011 1257
2012 1353
2013 1390
2014 1415
2015 1548
2016 1374
2017 1291
2018 1114
2019 513
2020 6
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19,024 results
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Page 1
A concert of RNA-binding proteins coordinates mitochondrial function.
Schatton D and Rugarli EI. Crit Rev Biochem Mol Biol 2018 - Review. PMID 30741581
At the heart of post-transcriptional responses are a number of RNA-binding proteins that specifically bind mRNAs encoding mitochondrial proteins and define their fate, by influencing transcript maturation, stability, translation, and localization. Thus, RNA-binding proteins provide a uniquely complex regulatory code that orchestrates mitochondrial function during physiological and pathological conditions....
At the heart of post-transcriptional responses are a number of RNA-binding proteins that specifically bind mRNAs encoding mitochon
Mitochondrial protein translocation-associated degradation.
Mårtensson CU, et al. Nature 2019. PMID 31118508
Mitochondrial biogenesis and functions depend on the import of precursor proteins via the 'translocase of the outer membrane' (TOM complex). ...The mitoTAD pathway ensures that mitochondria maintain their full protein-import capacity, and protects cells against proteotoxic stress induced by impaired transport of proteins into mitochondria....
Mitochondrial biogenesis and functions depend on the import of precursor proteins via the 'translocase of the outer membrane'
Recruitment of Cytosolic J-Proteins by TOM Receptors Promotes Mitochondrial Protein Biogenesis.
Opaliński Ł, et al. Cell Rep 2018. PMID 30463002 Free PMC article.
Mitochondria possess elaborate machineries for the import of proteins from the cytosol. Cytosolic factors like Hsp70 chaperones and their co-chaperones, the J-proteins, guide proteins to the mitochondrial surface. ...Our findings suggest that cytosolic J-proteins target distinct TOM receptors and promote the biogenesis of mitochondrial proteins....
Mitochondria possess elaborate machineries for the import of proteins from the cytosol. Cytosolic factors like Hsp70 chaperone
Strangers in strange lands: mitochondrial proteins found at extra-mitochondrial locations.
Scanlon DP and Salter MW. Biochem J 2019 - Review. PMID 30617163
The mitochondrial proteome is estimated to contain ∼1100 proteins, the vast majority of which are nuclear-encoded, with only 13 proteins encoded by the mitochondrial genome. The import of these nuclear-encoded proteins into mitochondria was widely believed to be unidirectional, but recent discoveries have revealed that many these 'mitochondrial' proteins are exported, and have extra-mitochondrial activities divergent from their mitochondrial function. ...
The mitochondrial proteome is estimated to contain ∼1100 proteins, the vast majority of which are nuclear-encoded, with only 1 …
Posttranslational modifications of mitochondrial fission and fusion proteins in cardiac physiology and pathophysiology.
Adaniya SM, et al. Am J Physiol Cell Physiol 2019 - Review. PMID 30758993 Free PMC article.
Thus, understanding the PTMs of fission and fusion proteins may allow us to understand the complexities that determine the balance of mitochondrial fission and fusion as well as mitochondrial function in various cell types and organs including cardiomyocytes and the heart. ...We also discuss the molecular mechanisms underlying abnormal mitochondrial morphology in HF and their contributions to the development of cardiac diseases, highlighting the crucial roles of PTMs of mitochondrial fission and fusion proteins. ...
Thus, understanding the PTMs of fission and fusion proteins may allow us to understand the complexities that determine the balance of …
Overproduction of Mitochondrial Fission Proteins in Membranous Nephropathy in Children.
Wei QJ, et al. Kidney Blood Press Res 2018. PMID 30566949 Free article.
Mitochondrial fission proteins are found to be involved in podocyte injury in vitro. Increased glomerular expression of mitochondrial fission proteins was found in adriamycin nephropathy in our previous study. Whether or not mitochondrial fission proteins are involved in podocyte injury in NS is not clear. This study explored the glomerular expression and possible pathological significance of mitochondrial fission-associated proteins, including dynamin-related protein 1 (Drp1) and mitochondrial fission protein 1 (Fis1), in children with NS. ...
Mitochondrial fission proteins are found to be involved in podocyte injury in vitro. Increased glomerular expression of mit
Neofunctionalization of Mitochondrial Proteins and Incorporation into Signaling Networks in Plants.
Lama S, et al. Mol Biol Evol 2019. PMID 30938771 Free PMC article.
Because of their symbiotic origin, many mitochondrial proteins are well conserved across eukaryotic kingdoms. It is however less obvious how specific lineages have obtained novel nuclear-encoded mitochondrial proteins. ...Overall, this study provides insight into how novel mitochondrial proteins can be created via "intercompartmental" gene duplication events. ...
Because of their symbiotic origin, many mitochondrial proteins are well conserved across eukaryotic kingdoms. It is however le …
Mitochondrial Proteins in the Development of Parkinson's Disease.
Zilocchi M, et al. Adv Exp Med Biol 2019. PMID 31452133
Strong evidences suggest that mitochondrial impairment and altered mitochondrial disposal play a key role in the development of this pathology. ...In particular, we focus our attention on mitochondrial dynamics, mitochondrial biogenesis, and mitophagy and explain how their impairment could have a negative impact on dopaminergic neurons function and survival. ...
Strong evidences suggest that mitochondrial impairment and altered mitochondrial disposal play a key role in the development o …
The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging.
D'Amico D, et al. Mol Cell 2019. PMID 30642763 Free PMC article.
Multi-omics and cross-species analyses of PUM2 function show that it inhibits the translation of the mRNA encoding for the mitochondrial fission factor (Mff), thereby impairing mitochondrial fission and mitophagy. ...Our data reveal how a PUM2-mediated layer of post-transcriptional regulation links altered Mff translation to mitochondrial dynamics and mitophagy, thereby mediating age-related mitochondrial dysfunctions....
Multi-omics and cross-species analyses of PUM2 function show that it inhibits the translation of the mRNA encoding for the mitochondrial
A mitochondrial FUNDC1/HSC70 interaction organizes the proteostatic stress response at the risk of cell morbidity.
Li Y, et al. EMBO J 2019. PMID 30591555 Free PMC article.
Integrative approaches including csCLEM, Apex, and biochemical analysis reveal that MAPAs contain ubiquitinated cytosolic proteins, autophagy receptor p62, and mitochondrial proteins. MAPAs are segregated from mitochondria in a FIS1-dependent manner and can subsequently be degraded via autophagy. Although the FUNDC1/HSC70 pathway promotes the degradation of unfolded cytosolic proteins, excessive accumulation of unfolded proteins on the mitochondria prior to MAPA formation impairs mitochondrial integrity and activates AMPK, leading to cellular senescence. ...
Integrative approaches including csCLEM, Apex, and biochemical analysis reveal that MAPAs contain ubiquitinated cytosolic proteins, a …
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