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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1974 3
1975 2
1976 10
1977 15
1978 14
1979 19
1980 17
1981 17
1982 20
1983 26
1984 22
1985 16
1986 16
1987 14
1988 14
1989 17
1990 12
1991 12
1992 9
1993 18
1994 16
1995 12
1996 16
1997 17
1998 18
1999 15
2000 29
2001 37
2002 104
2003 147
2004 195
2005 247
2006 321
2007 425
2008 502
2009 525
2010 611
2011 672
2012 736
2013 734
2014 702
2015 797
2016 788
2017 780
2018 794
2019 346
2020 5
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8,685 results
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Page 1
Importing mitochondrial proteins: machineries and mechanisms.
Chacinska A, et al. Cell 2009 - Review. PMID 19703392 Free PMC article.
Most mitochondrial proteins are synthesized on cytosolic ribosomes and must be imported across one or both mitochondrial membranes. ...Here, we discuss recent insights into the importing and sorting of mitochondrial proteins and their contributions to mitochondrial biogenesis....
Most mitochondrial proteins are synthesized on cytosolic ribosomes and must be imported across one or both mitochondrial
Ubiquitin-Dependent Degradation of Mitochondrial Proteins Regulates Energy Metabolism.
Lavie J, et al. Cell Rep 2018. PMID 29874573 Free article.
Here, we show that ubiquitination occurs in different mitochondrial compartments, including the inner mitochondrial membrane, and that turnover of several metabolic proteins is UPS dependent. We specifically detailed mitochondrial ubiquitination and subsequent UPS-dependent degradation of succinate dehydrogenase subunit A (SDHA), which occurred when SDHA was minimally involved in mitochondrial energy metabolism. ...
Here, we show that ubiquitination occurs in different mitochondrial compartments, including the inner mitochondrial membrane, …
Mitofusins, from Mitochondria to Metabolism.
Schrepfer E and Scorrano L. Mol Cell 2016 - Review. PMID 26942673 Free article.
As key regulators of mitochondrial dynamics, the fusogenic mitofusins have recently been linked to mitochondrial biogenesis and respiratory functions, impacting on cell fate and organism homeostasis. Here we review the implication of mitofusins in the regulation of mitochondrial metabolism, and their consequence on energy homeostasis at the cellular and physiological level, highlighting their crucial role in metabolic disorders, cancer, and aging....
As key regulators of mitochondrial dynamics, the fusogenic mitofusins have recently been linked to mitochondrial biogenesis an …
Mitochondrial Machineries for Protein Import and Assembly.
Wiedemann N and Pfanner N. Annu Rev Biochem 2017 - Review. PMID 28301740
Mitochondria are essential organelles with numerous functions in cellular metabolism and homeostasis. Most of the >1,000 different mitochondrial proteins are synthesized as precursors in the cytosol and are imported into mitochondria by five transport pathways. ...Here, we discuss the versatility and dynamic organization of the mitochondrial protein import machineries. Elucidating the molecular mechanisms of mitochondrial protein translocation is crucial for understanding the integration of protein translocases into a large network that controls organelle biogenesis, function, and dynamics....
Mitochondria are essential organelles with numerous functions in cellular metabolism and homeostasis. Most of the >1,000 di
Failed mitochondrial import and impaired proteostasis trigger SUMOylation of mitochondrial proteins.
Paasch F, et al. J Biol Chem 2018. PMID 29183993 Free PMC article.
Here, we identify a large set of structurally and functionally unrelated mitochondrial proteins as substrates of the SUMO pathway in yeast. We show that SUMO modification of mitochondrial proteins does not rely on mitochondrial targeting and, in fact, is strongly enhanced upon import failure, consistent with the modification occurring in the cytosol. ...
Here, we identify a large set of structurally and functionally unrelated mitochondrial proteins as substrates of the SUMO path …
Appoptosin interacts with mitochondrial outer-membrane fusion proteins and regulates mitochondrial morphology.
Zhang C, et al. J Cell Sci 2016. PMID 26813789 Free PMC article.
Although appoptosin did not affect levels of mitochondrial outer-membrane fusion (MFN1 and MFN2), inner-membrane fusion (OPA1) and fission [DRP1 (also known as DNM1L) and FIS1] proteins, appoptosin interacted with MFN1 and MFN2, as well as with the mitochondrial ubiquitin ligase MITOL (also known as MARCH5) but not OPA1, FIS1 or DRP1. ...Together, our results demonstrate that appoptosin can interact with mitochondrial outer-membrane fusion proteins and regulates mitochondrial morphology....
Although appoptosin did not affect levels of mitochondrial outer-membrane fusion (MFN1 and MFN2), inner-membrane fusion (OPA1) and fi …
MitoCarta2.0: an updated inventory of mammalian mitochondrial proteins.
Calvo SE, et al. Nucleic Acids Res 2016. PMID 26450961 Free PMC article.
Mitochondria are complex organelles that house essential pathways involved in energy metabolism, ion homeostasis, signalling and apoptosis. ...In 2008, we made substantial progress toward this goal by performing in-depth mass spectrometry of mitochondria from 14 organs, epitope tagging/microscopy and Bayesian integration to assemble MitoCarta (www.broadinstitute.org/pubs/MitoCarta): an inventory of genes encoding mitochondrial-localized proteins and their expression across 14 mouse tissues. ...
Mitochondria are complex organelles that house essential pathways involved in energy metabolism, ion homeostasis, signalling a
Structure, function, and regulation of mitofusin-2 in health and disease
Chandhok G, et al. Biol Rev Camb Philos Soc 2018 - Review. PMID 29068134 Free PMC article.
Mitofusins (Mfn1/2), optic atrophy 1 (OPA1), and dynamin-related protein 1 (Drp1), are key regulators of mitochondrial fusion and fission. ...In recent years, significant progress has been made in our understanding of mitochondrial dynamics, which has raised interest in defining the physiological roles of key regulators of fusion and fission and led to the identification of additional functions of Mfn2 in mitochondrial metabolism, cell signalling, and apoptosis. ...
Mitofusins (Mfn1/2), optic atrophy 1 (OPA1), and dynamin-related protein 1 (Drp1), are key regulators of mitochondrial fusion and fis …
Determinants of the cytosolic turnover of mitochondrial intermembrane space proteins.
Kowalski L, et al. BMC Biol 2018. PMID 29929515 Free PMC article.
BACKGROUND: The proteome of mitochondria comprises mostly proteins that originate as precursors in the cytosol. Before import into the organelle, such proteins are exposed to cytosolic quality control mechanisms. ...Proteins that are directed to the mitochondrial intermembrane space (IMS) exemplify an entire class of mitochondrial proteins regulated by proteasomal degradation. ...
BACKGROUND: The proteome of mitochondria comprises mostly proteins that originate as precursors in the cytosol. Before import …
Mitochondrial Proteins Moonlighting in the Nucleus.
Monaghan RM and Whitmarsh AJ. Trends Biochem Sci 2015 - Review. PMID 26520802
Several proteins that contain mitochondrial-targeting sequences (MTS) also reside in the nucleus and there is increasing evidence that the nuclear translocation of mitochondrial proteins represents a novel pathway by which mitochondria signal their status to the cell. Here, we discuss the different mechanisms that control the dual mitochondrial and nuclear localisation of proteins and propose that these nuclear moonlighters represent a widespread regulatory circuit to maintain mitochondrial homeostasis....
Several proteins that contain mitochondrial-targeting sequences (MTS) also reside in the nucleus and there is increasing evide …
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