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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1997 1
1998 3
1999 14
2000 23
2001 36
2002 29
2003 34
2004 36
2005 30
2006 56
2007 56
2008 98
2009 75
2010 127
2011 174
2012 157
2013 186
2014 154
2015 183
2016 172
2017 162
2018 139
2019 55
2020 0
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1,768 results
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Page 1
Mitogen-Activated Protein Kinase Pathway: Genetic Analysis of 95 Adrenocortical Tumors.
Rubin B, et al. Cancer Invest 2015. PMID 26536286
Mitogen-activated protein kinase (MAPK) pathway is often deregulated in adrenocortical tumors (ACT) but with no concrete data confirming alteration rate. ...Therefore, even if MAPK signaling is activated in ACT, our results suggest that genetic alterations do not seem to represent a frequent mechanism of ACT tumorigenesis....
Mitogen-activated protein kinase (MAPK) pathway is often deregulated in adrenocortical tumors (ACT) but with no
The RNA-Binding Protein PCBP1 Functions as a Tumor Suppressor in Prostate Cancer by Inhibiting Mitogen Activated Protein Kinase 1.
Zhang Y, et al. Cell Physiol Biochem 2018. PMID 30078000 Free article.
BACKGROUND/AIMS: Poly r(C) binding protein (PCBP) 1 or heterogeneous ribonucleoprotein (hnRNP) E1 is a RNA binding protein functional in multiple biological processes. ...RESULTS: The expression of mitogen activated protein kinase 1 (MAPK1) or extracellular signal regulated kinase 2 (ERK2) was increased following PCBP1 loss. ...
BACKGROUND/AIMS: Poly r(C) binding protein (PCBP) 1 or heterogeneous ribonucleoprotein (hnRNP) E1 is a RNA binding protein
MicroRNA-212 Targets Mitogen-Activated Protein Kinase 1 to Inhibit Proliferation and Invasion of Prostate Cancer Cells.
Hu B, et al. Oncol Res 2018. PMID 29321092
In addition, mitogen-activated protein kinase 1 (MAPK1), a well-known oncogene, was identified as a novel target of miR-212 in PCa, as confirmed by bioinformatics, luciferase reporter assay, qRT-PCR, and Western blot analysis. ...
In addition, mitogen-activated protein kinase 1 (MAPK1), a well-known oncogene, was identified as a novel …
HIV-induced matrix metalloproteinase-9 activation through mitogen-activated protein kinase signalling promotes HSV-1 cell-to-cell spread in oral epithelial cells.
Sufiawati I and Tugizov SM. J Gen Virol 2018. PMID 29775175 Free PMC article.
We have shown that cell-free HIV-1 and viral proteins tat and gp120 activate mitogen-activated protein kinases (MAPKs) in tonsil epithelial cells, disrupting their tight and adherens junctions. ...Inactivation of MMP-9 also reduced HIV-promoted HSV-1 spread. These results indicate that HIV-1-activated MAPK/NF-κB and MMP-9 play a critical role in the disruption of oral epithelial junctions and HSV-1 cell-to-cell spread. ...
We have shown that cell-free HIV-1 and viral proteins tat and gp120 activate mitogen-activated protein kinases ( …
Mitogen-activated protein kinase 1 from disk abalone (Haliotis discus discus): Roles in early development and immunity-related transcriptional responses.
Perera NCN, et al. Fish Shellfish Immunol 2016. PMID 27765698
Mitogen-activated protein kinase (MAPK) is involved in the regulation of cellular events by mediating signal transduction pathways. ...In addition, a conservative glycine rich ATP-phosphate-binding loop and a threonine-x-tyrosine motif (TEY) important for the autophosphorylation were also identified in the protein. ...
Mitogen-activated protein kinase (MAPK) is involved in the regulation of cellular events by mediating signal tra
Deletion of mitogen-activated protein kinase 1 inhibits development and growth of Toxoplasma gondii.
Cao L, et al. Parasitol Res 2016. PMID 26526952
Mitogen-activated protein kinases (MAPKs) regulate key signaling events in a variety of eukaryotic cells. Toxoplasma gondii, the causative agents of toxoplasmosis, possesses a p38α MAPK homologue, MAPK1, which is an important manipulator of host immunity and virulence in mice. ...
Mitogen-activated protein kinases (MAPKs) regulate key signaling events in a variety of eukaryotic cells. Toxoplasma go
Mitogen- and stress-activated protein kinase 1 mediates activation of Akt by ultraviolet B irradiation.
Nomura M, et al. J Biol Chem 2001. PMID 11350959 Free article.
Interestingly, Akt activation by UVB was attenuated by treatment with PD 98059, a specific mitogen-activated protein kinase/extracellular signal-regulated protein kinase (Erk) kinase 1 inhibitor, or SB 202190, a specific p38 kinase inhibitor. ...Instead, Akt was phosphorylated at both threonine 308 and serine 473 and activated by UVB-activated mitogen- and stress-activated protein kinase 1 (Msk1). ...
Interestingly, Akt activation by UVB was attenuated by treatment with PD 98059, a specific mitogen-activated protein
Repression of breast cancer cell growth by proteasome inhibitors in vitro: impact of mitogen-activated protein kinase phosphatase 1.
Patel BS, et al. Cancer Biol Ther 2015. PMID 25774547 Free PMC article.
Mitogen activated protein kinase phosphatase-1 (MKP-1) has emerged as an important protein mediating breast cancer oncogenesis and chemoresistance to cancer chemotherapies, especially proteasome inhibitors. ...Notably, these effects are specific to cancer cells, as bortezomib activated p38 MAPK and induced MKP-1 in MCF-7 and MDA-MB-231 breast cancer cells, but not in control cells (MCF-10A). ...
Mitogen activated protein kinase phosphatase-1 (MKP-1) has emerged as an important protein
Local destabilization, rigid body, and fuzzy docking facilitate the phosphorylation of the transcription factor Ets-1 by the mitogen-activated protein kinase ERK2.
Piserchio A, et al. Proc Natl Acad Sci U S A 2017. PMID 28716922 Free PMC article.
Mitogen-activated protein (MAP) kinase substrates are believed to require consensus docking motifs (D-site, F-site) to engage and facilitate efficient site-specific phosphorylation at specific serine/threonine-proline sequences by their cognate kinases. In contrast to other MAP kinase substrates, the transcription factor Ets-1 has no canonical docking motifs, yet it is efficiently phosphorylated by the MAP kinase ERK2 at a consensus threonine site (T38). ...
Mitogen-activated protein (MAP) kinase substrates are believed to require consensus docking motifs (D-site, F-si
MicroRNA-454 inhibits the malignant biological behaviours of gastric cancer cells by directly targeting mitogen-activated protein kinase 1.
Wang X, et al. Oncol Rep 2018. PMID 29286172
Subsequently, mitogen‑activated protein kinase 1 (MAPK1) was identified as a direct target of miR‑454. MAPK1 was upregulated in GC tissues and was found to be negatively correlated with the miR‑454 expression level. ...
Subsequently, mitogen‑activated protein kinase 1 (MAPK1) was identified as a direct target of miR‑454. MAPK1 was upregu …
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