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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1997 15
1998 40
1999 94
2000 159
2001 189
2002 198
2003 234
2004 222
2005 189
2006 255
2007 245
2008 287
2009 233
2010 254
2011 266
2012 185
2013 182
2014 180
2015 181
2016 143
2017 145
2018 102
2019 49
2020 0
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3,605 results
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Page 1
ERK1/2 MAP kinases: structure, function, and regulation
Roskoski R. Pharmacol Res 2012 - Review. PMID 22569528
A variety of scaffold proteins including KSR1/2, IQGAP1, MP1, β-Arrestin1/2 participate in the regulation of the ERK1/2 MAP kinase cascade. The regulatory dephosphorylation of ERK1/2 is mediated by protein-tyrosine specific phosphatases, protein-serine/threonine phosphatases, and dual specificity phosphatases. ...
A variety of scaffold proteins including KSR1/2, IQGAP1, MP1, β-Arrestin1/2 participate in the regulation of the ERK1/2 MAP kinase ca …
The RNA-Binding Protein PCBP1 Functions as a Tumor Suppressor in Prostate Cancer by Inhibiting Mitogen Activated Protein Kinase 1.
Zhang Y, et al. Cell Physiol Biochem 2018. PMID 30078000 Free article.
BACKGROUND/AIMS: Poly r(C) binding protein (PCBP) 1 or heterogeneous ribonucleoprotein (hnRNP) E1 is a RNA binding protein functional in multiple biological processes. ...RESULTS: The expression of mitogen activated protein kinase 1 (MAPK1) or extracellular signal regulated kinase 2 (ERK2) was increased following PCBP1 loss. ...
BACKGROUND/AIMS: Poly r(C) binding protein (PCBP) 1 or heterogeneous ribonucleoprotein (hnRNP) E1 is a RNA binding protein
Regulation of mitogen-activated protein kinase 3/1 activity during meiosis resumption in mammals.
Prochazka R and Blaha M. J Reprod Dev 2015 - Review. PMID 26688146 Free PMC article.
All new evidence argues for a multiple roles of mitogen-activated protein kinase 3/1 (MAPK3/1) in the gonadotropin-induced ovulation processes. ...In this review, we aimed to summarize recent advances in the elucidation of gonadotropin-induced mechanisms leading to the activation of MAPK3/1 in preovulatory follicles and cultured cumulus-oocyte complexes and to point out a specific role of this kinase in the processes accompanying final maturation of the mammalian oocyte....
All new evidence argues for a multiple roles of mitogen-activated protein kinase 3/1 (MAPK3/1) in …
MiR-378a-3p enhances adipogenesis by targeting mitogen-activated protein kinase 1.
Huang N, et al. Biochem Biophys Res Commun 2015. PMID 25529446
Mir-378a-3p induced adipogenesis by targeting mitogen-activated protein kinase 1 (MAPK1). Overexpression of miR-378a-3p or silencing MAPK1 reduced MAPK1 expression and enhanced adipogenesis, whereas blockage of endogenous miR-378a-3p had the opposite effect, suggesting that miR-378a-3p promotes the adipogenesis of 3T3-L1 cells by targeting MAPK1....
Mir-378a-3p induced adipogenesis by targeting mitogen-activated protein kinase 1 (MAPK1). Overexpression …
Effect of contraction on mitogen-activated protein kinase signal transduction in skeletal muscle. Involvement Of the mitogen- and stress-activated protein kinase 1.
Ryder JW, et al. J Biol Chem 2000. PMID 10625698 Free article.
Growing evidence suggests that activation of mitogen-activated protein kinase (MAPK) signal transduction mediates changes in muscle gene expression in response to exercise. ...Muscle contraction also activated MAPK downstream targets p90 ribosomal S6 kinase (p90(Rsk)), MAPK-activated protein kinase 2 (MAPKAP-K2), and mitogen- and stress-activated protein kinase 1 (MSK1). ...
Growing evidence suggests that activation of mitogen-activated protein kinase (MAPK) signal transduction mediate …
Cancer drug addiction is relayed by an ERK2-dependent phenotype switch
Kong X, et al. Nature 2017. PMID 28976960 Free PMC article.
We performed an unbiased CRISPR-Cas9 knockout screen on melanoma cells that were both resistant and addicted to inhibition of the serine/threonine-protein kinase BRAF, in order to functionally mine their genome for 'addiction genes'. Here we describe a signalling pathway comprising ERK2 kinase and JUNB and FRA1 transcription factors, disruption of which allowed addicted tumour cells to survive on treatment discontinuation. ...
We performed an unbiased CRISPR-Cas9 knockout screen on melanoma cells that were both resistant and addicted to inhibition of the serine/thr …
Local destabilization, rigid body, and fuzzy docking facilitate the phosphorylation of the transcription factor Ets-1 by the mitogen-activated protein kinase ERK2.
Piserchio A, et al. Proc Natl Acad Sci U S A 2017. PMID 28716922 Free PMC article.
Mitogen-activated protein (MAP) kinase substrates are believed to require consensus docking motifs (D-site, F-site) to engage and facilitate efficient site-specific phosphorylation at specific serine/threonine-proline sequences by their cognate kinases. In contrast to other MAP kinase substrates, the transcription factor Ets-1 has no canonical docking motifs, yet it is efficiently phosphorylated by the MAP kinase ERK2 at a consensus threonine site (T38). ...
Mitogen-activated protein (MAP) kinase substrates are believed to require consensus docking motifs (D-site, F-si
Mitogen-activated protein kinase 2 regulates physiological and pathological bone turnover.
Braun T, et al. J Bone Miner Res 2013. PMID 23169443 Free article.
The objective of this study was to investigate the role of the serine-threonine kinase mitogen-activated protein kinase 2 (MK2) in bone homeostasis. ...Mechanistically, loss of MK2 causes impaired DNA binding of c-fos and nuclear factor of activated T cells cytoplasmic 1 (NFATc1) to tartrate-resistant acid phosphatase (TRAP) and the calcitonin receptor gene promoter. ...
The objective of this study was to investigate the role of the serine-threonine kinase mitogen-activated protein
Rapid activation of ERK1/2 mitogen-activated protein kinase by corticosterone in PC12 cells.
Qiu J, et al. Biochem Biophys Res Commun 2001. PMID 11573966
The present study using Western immunoblot and protein kinase activity assay, for the first time, showed that corticosterone (B) can induce a rapid activation of Erk1/2 mitogen-activated protein kinase (MAPK) in PC12 cells. ...On the other hand, protein kinase C activator (PMA) can activate and protein kinase C inhibitor (Gö6976) can block the activation of Erk1/2 MAPK induced by B. ...
The present study using Western immunoblot and protein kinase activity assay, for the first time, showed that corticosterone ( …
Interaction of kinase-interaction-motif protein tyrosine phosphatases with the mitogen-activated protein kinase ERK2.
Francis DM, et al. PLoS One 2014. PMID 24637728 Free PMC article.
The mitogen-activation protein kinase ERK2 is tightly regulated by multiple phosphatases, including those of the kinase interaction motif (KIM) PTP family (STEP, PTPSL and HePTP). ...
The mitogen-activation protein kinase ERK2 is tightly regulated by multiple phosphatases, including those of the kin
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