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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1990 2
1991 9
1992 19
1993 41
1994 83
1995 137
1996 319
1997 483
1998 721
1999 1264
2000 2226
2001 2845
2002 3143
2003 3472
2004 2683
2005 1017
2006 1052
2007 1064
2008 1022
2009 933
2010 1053
2011 1082
2012 1087
2013 1018
2014 953
2015 891
2016 901
2017 879
2018 853
2019 433
2020 5
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29,263 results
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Page 1
Roles of Mitogen-Activated Protein Kinases in Osteoclast Biology.
Lee K, et al. Int J Mol Sci 2018 - Review. PMID 30275408 Free PMC article.
Signaling mediated by mitogen-activated protein kinases (MAPKs), including extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38, has been recognized to be critical for normal osteoclast differentiation and activation. ...
Signaling mediated by mitogen-activated protein kinases (MAPKs), including extracellular signal-regulated kinase …
Mitogen-Activated Protein Kinases: Functions in Signal Transduction and Human Diseases.
Tikkanen R and Nikolic-Paterson DJ. Int J Mol Sci 2019. PMID 31569533 Free PMC article.
Mitogen-activated protein kinases (MAPKs) are involved in signaling processes induced by various stimuli, such as growth factors, stress, or even autoantibodies [...]....
Mitogen-activated protein kinases (MAPKs) are involved in signaling processes induced by various stimuli, such a
Thrombomodulin Regulation of Mitogen-Activated Protein Kinases.
Giri H, et al. Int J Mol Sci 2019 - Review. PMID 30991642 Free PMC article.
The multifaceted role of mitogen-activated protein kinases (MAPKs) in modulating signal transduction pathways in inflammatory conditions such as infection, cardiovascular disease, and cancer has been well established. ...
The multifaceted role of mitogen-activated protein kinases (MAPKs) in modulating signal transduction pathways in …
Role of Mitogen Activated Protein Kinase Signaling in Parkinson's Disease.
Bohush A, et al. Int J Mol Sci 2018 - Review. PMID 30274251 Free PMC article.
In recent years, genetic studies have prominently advocated for the role of improper protein phosphorylation caused by a dysfunction in kinases and/or phosphatases as an important player in progression and pathogenesis of PD. Thus, in this review, we focus on the role of selected MAP kinases such as JNKs, ERK1/2, and p38 MAP kinases in PD pathology....
In recent years, genetic studies have prominently advocated for the role of improper protein phosphorylation caused by a dysfunction …
Mitogen Activated Protein Kinases in Steatotic and Non-Steatotic Livers Submitted to Ischemia-Reperfusion.
Jiménez-Castro MB, et al. Int J Mol Sci 2019 - Review. PMID 30974915 Free PMC article.
: We analyzed the participation of mitogen-activated protein kinases (MAPKs), namely p38, JNK and ERK 1/2 in steatotic and non-steatotic livers undergoing ischemia-reperfusion (I-R), an unresolved problem in clinical practice. ...The data presented herein suggest that further investigations are required to elucidate more extensively the mechanisms by which these kinases work in hepatic I-R. ...
: We analyzed the participation of mitogen-activated protein kinases (MAPKs), namely p38, JNK and ERK 1/2 in ste …
Mitogen-activated protein kinases MPK3 and MPK6 are required for stem cell maintenance in the Arabidopsis shoot apical meristem.
Lee H, et al. Plant Cell Rep 2019. PMID 30552452 Free PMC article.
Here, we report that mitogen-activated protein kinases (MAPKs, also known as MPKs in plants) act in an intracellular signaling cascade to play an important role in the maintenance of SAM development. ...Taken together, these results suggest that MPK3 and MPK6 activated by CLV3p signals through mainly CLV1 and BAM1 receptors are key regulators controlling stem cell homeostasis in the SAM....
Here, we report that mitogen-activated protein kinases (MAPKs, also known as MPKs in plants) act in an intracell …
The Importance of the Right Framework: Mitogen-Activated Protein Kinase Pathway and the Scaffolding Protein PTPIP51.
Dietel E, et al. Int J Mol Sci 2018 - Review. PMID 30360441 Free PMC article.
The protein tyrosine phosphatase interacting protein 51 (PTPIP51) regulates and interconnects signaling pathways, such as the mitogen-activated protein kinase (MAPK) pathway and an abundance of different others, e.g., Akt signaling, NF-κB signaling, and the communication between different cell organelles. ...The phosphorylation status is finely tuned by receptor tyrosine kinases (EGFR, Her2), non-receptor tyrosine kinases (c-Src) and the phosphatase protein tyrosine phosphatase 1B (PTP1B). ...
The protein tyrosine phosphatase interacting protein 51 (PTPIP51) regulates and interconnects signaling pathways, such as the …
Mitogen-activated protein kinases MPK4 and MPK12 are key components mediating CO(2) -induced stomatal movements.
Tõldsepp K, et al. Plant J 2018. PMID 30203878 Free PMC article.
Recently, mutations in the mitogen-activated protein (MAP) kinase, MPK12, have been shown to partially impair CO(2) -induced stomatal closure. ...The activities of MPK4 and MPK12 protein kinases were not directly modulated by CO(2) /bicarbonate in vitro, suggesting that they are not direct CO(2) /bicarbonate sensors. ...
Recently, mutations in the mitogen-activated protein (MAP) kinase, MPK12, have been shown to partially impair CO(2) -in …
Mitogen-Activated Protein Kinase Cross-Talk Interaction Modulates the Production of Melanins in Aspergillus fumigatus.
Manfiolli AO, et al. mBio 2019. PMID 30914505 Free PMC article.
The A. fumigatus genome contains four genes coding for mitogen-activated protein kinases (MAPKs), which are important regulatory knots involved in diverse cellular responses. ...Additionally, DHN-melanin formation was also increased after deletion of genes coding for the Gα protein GpaA and for the G protein-coupled receptor GprM. ...
The A. fumigatus genome contains four genes coding for mitogen-activated protein kinases (MAPKs), which are impo …
NK cell-mediated cytotoxicity contributes to tumor control by a cytostatic drug combination
Ruscetti M, et al. Science 2018. PMID 30573629 Free PMC article.
We show that mitogen-activated protein kinase (MAPK) and cyclin-dependent kinase 4/6 inhibitors act in combination to suppress the proliferation of KRAS-mutant lung cancer cells while simultaneously provoking a natural killer (NK) cell surveillance program leading to tumor cell death. The drug combination, but neither agent alone, promotes retinoblastoma (RB) protein-mediated cellular senescence and activation of the immunomodulatory senescence-associated secretory phenotype (SASP). ...
We show that mitogen-activated protein kinase (MAPK) and cyclin-dependent kinase 4/6 inhibitors act in combination to s …
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