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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2004 1
2006 1
2007 3
2008 5
2009 23
2010 777
2011 2482
2012 2652
2013 3340
2014 3849
2015 4191
2016 4170
2017 3978
2018 3241
2019 1467
2020 29
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26,774 results
Results by year
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Page 1
Targeted therapy in cancer.
Tsimberidou AM. Cancer Chemother Pharmacol 2015 - Review. PMID 26391154 Free PMC article.
PURPOSE: To describe the emergence of targeted therapies that have led to significant breakthroughs in cancer therapy and completed or ongoing clinical trials of novel agents for the treatment of patients with advanced cancer. ...Tumor molecular profiling has enabled the reclassification of cancer and elucidated some mechanisms of disease progression or resistance to treatment, the heterogeneity between primary and metastatic tumors, and the dynamic changes of tumor molecular profiling over time. ...
PURPOSE: To describe the emergence of targeted therapies that have led to significant breakthroughs in cancer therapy and comp …
Prospects for combining targeted and conventional cancer therapy with immunotherapy.
Gotwals P, et al. Nat Rev Cancer 2017 - Review. PMID 28338065
In one approach, efforts to understand the underlying cell-autonomous, genetic drivers of tumorigenesis have led to the development of clinically important targeted agents that result in profound, but often not durable, tumour responses in genetically defined patient populations. ...Targeted and immune-based therapies have already transformed the standard-of-care for several malignancies. However, additional insights into the effects of targeted therapies, along with conventional chemotherapy and radiation therapy, on the induction of antitumour immunity will help to advance the design of combination strategies that increase the rate of complete and durable clinical response in patients....
In one approach, efforts to understand the underlying cell-autonomous, genetic drivers of tumorigenesis have led to the development of clini …
Molecular mechanism and targeted therapy of Hsp90 involved in lung cancer: New discoveries and developments (Review).
Rong B and Yang S. Int J Oncol 2018 - Review. PMID 29207057
The exploration of the molecular mechanisms and signaling pathways on lung cancer is very important for developing new strategies of diagnosis and treatment to this disease, such as finding valuable lung cancer markers and molecularly targeted therapies. ...In addition, a series of Hsp90 inhibitors have been investigated as effective molecular targeted therapy tactics fighting against lung cancer. ...
The exploration of the molecular mechanisms and signaling pathways on lung cancer is very important for developing new strategies of …
Precision medicine in pediatric oncology
Forrest SJ, et al. Curr Opin Pediatr 2018 - Review. PMID 29189430 Free PMC article.
PURPOSE OF REVIEW: The current review describes recent advances and unique challenges in precision medicine for pediatric cancers and highlights clinical trials assessing the clinical impact of targeted therapy matched to molecular alterations identified by tumor profiling. ...SUMMARY: The primary results of the first round of pediatric precision oncology clinical trials will provide us with a greater understanding of the clinical impact of linking tumor profiling to selection of targeted therapies. ...
PURPOSE OF REVIEW: The current review describes recent advances and unique challenges in precision medicine for pediatric cancers and highli …
[Molecular tumour therapy].
Michel C, et al. Internist (Berl) 2015 - Review. PMID 26585240 German.
In recent years, molecular tumour therapy has dramatically improved the treatment of various types of cancer. Molecular therapy is expected to attack malignant cells more specifically with fewer side effects than conventional chemotherapy. Both kinase inhibitors and monoclonal antibodies are key components of today's molecular cancer therapy. These substances cannot fully overcome the major tumour-biological problems, e.g. therapy resistance. ...
In recent years, molecular tumour therapy has dramatically improved the treatment of various types of cancer. Molecular
[Molecular targeted therapy].
Tanaka Y, et al. Brain Nerve 2014. PMID 25597049 Japanese.
Systemic lupus erythematosus
Lisnevskaia L, et al. Lancet 2014 - Review. PMID 24881804
Increased understanding of the cells and molecules involved in the development of the diseases has encouraged the identification of new, better targeted biological approaches to its treatment. ...
Increased understanding of the cells and molecules involved in the development of the diseases has encouraged the identification of new, bet …
Systemic Therapy for Hepatocellular Carcinoma: 2017 Update.
Kudo M. Oncology 2017 - Review. PMID 29258077 Free article.
Systemic therapy for hepatocellular carcinoma (HCC) changed drastically after the introduction of the molecular targeted agent sorafenib in 2007. ...The development of novel molecular targeted agents as alternatives to sorafenib has been limited by difficulties unique to HCC. ...
Systemic therapy for hepatocellular carcinoma (HCC) changed drastically after the introduction of the molecular targeted
Immune Effects of Chemotherapy, Radiation, and Targeted Therapy and Opportunities for Combination With Immunotherapy.
Wargo JA, et al. Semin Oncol 2015 - Review. PMID 26320064 Free PMC article.
There have been significant advances in cancer treatment over the past several years through the use of chemotherapy, radiation therapy, molecularly targeted therapy, and immunotherapy. ...Thus, the influence of chemotherapy, radiation therapy, and molecularly targeted therapy on the host anti-tumor immune response and the host anti-host response (ie, autoimmune toxicity) must be taken into consideration when designing immunotherapy-based combination regimens. ...
There have been significant advances in cancer treatment over the past several years through the use of chemotherapy, radiation therapy
Molecular Targeted Therapy in Modern Oncology: Imaging Assessment of Treatment Response and Toxicities.
Krajewski KM, et al. Korean J Radiol 2017 - Review. PMID 28096716 Free PMC article.
The use of therapies targeted to the molecular features of individual tumors and the tumor microenvironment has become much more common. In this review, anti-angiogenic and other molecular targeted therapies are discussed, with a focus on typical and atypical response patterns and imaging manifestations of drug toxicities....
The use of therapies targeted to the molecular features of individual tumors and the tumor microenvironment has become much mo …
26,774 results
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