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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 5
1946 16
1947 16
1948 26
1949 20
1950 22
1951 27
1952 23
1953 22
1954 32
1955 21
1956 40
1957 37
1958 40
1959 31
1960 39
1961 64
1962 51
1963 83
1964 195
1965 319
1966 390
1967 764
1968 1179
1969 1475
1970 1621
1971 2181
1972 2643
1973 3154
1974 3890
1975 3783
1976 3830
1977 3925
1978 3650
1979 4207
1980 4070
1981 3996
1982 4261
1983 4250
1984 4568
1985 5169
1986 5152
1987 4778
1988 4551
1989 5030
1990 5279
1991 4397
1992 3705
1993 3747
1994 3756
1995 3288
1996 3269
1997 2849
1998 2365
1999 2176
2000 2367
2001 2188
2002 1986
2003 2003
2004 1994
2005 2141
2006 2201
2007 2213
2008 2385
2009 2062
2010 2090
2011 2098
2012 2084
2013 2108
2014 1970
2015 1802
2016 1541
2017 1415
2018 1471
2019 948
2020 27
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153,181 results
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Page 1
Lead-like Drugs: A Perspective
Raymer B and Bhattacharya SK. J Med Chem 2018 - Review. PMID 30052440
Many of these recent drugs are close analogs of previously known drugs or natural substrates, with a key focus of their medicinal chemistry optimization being the choice of a low molecular weight starting point and maintaining low molecular weight during the optimization. However, the identification of low molecular weight starting points may be limited by the availability of suitable low molecular weight screening sets. ...
Many of these recent drugs are close analogs of previously known drugs or natural substrates, with a key focus of their medicinal chemistry …
Homo-Conjugation of Low Molecular Weight Organic Acids Competes with Their Complexation with Cu(II).
Zhao J, et al. Environ Sci Technol 2018. PMID 29664618
We used eight low molecular weight organic acids (LMOC) with representative structures to simulate DOM molecules. The interactions between LMOC molecules resulted in the decreased Cu(II)-LMOC binding with increasing LMOC concentrations, but higher pH values than theoretical calculation after mixing LMOC solutions of different pHs. ...
We used eight low molecular weight organic acids (LMOC) with representative structures to simulate DOM molecules. The interact …
Electrospray ionization for mass spectrometry of large biomolecules
Fenn JB, et al. Science 1989 - Review. PMID 2675315
Spectra have been obtained for biopolymers including oligonucleotides and proteins, the latter having molecular weights up to 130,000, with as yet no evidence of an upper limit....
Spectra have been obtained for biopolymers including oligonucleotides and proteins, the latter having molecular weights up to 130,000 …
Low Molecular Weight Nucleoside Gelators: A Platform for Protein Aggregation Inhibition.
Johnson L, et al. Mol Pharm 2019. PMID 30495960
Low molecular weight nucleoside gelators hold great promise in drug delivery and particularly for the delivery of biologics because of their excellent biocompatibility. ...
Low molecular weight nucleoside gelators hold great promise in drug delivery and particularly for the delivery of biologics be …
Molecular Weight Effects on the Glass Transition and Confinement Behavior of Polymer Thin Films.
Xia W, et al. Macromol Rapid Commun 2015. PMID 26033661
However, the coupled influence of molecular weight (MW) and surface effects on Tg is not well understood for low MW film systems below the entanglement length. Utilizing atomistically informed coarse-grained molecular dynamics simulations for poly(methyl methacrylate) (PMMA), it is demonstrated that the decrease in free-standing film Tg with respect to bulk is more significant for low MW compared to high MW systems. ...
However, the coupled influence of molecular weight (MW) and surface effects on Tg is not well understood for low MW film syste …
The molecular-weight range of mucosal-heparin preparations.
Johnson EA and Mulloy B. Carbohydr Res 1976. PMID 1000525
A recently reported method describes the determination of the molecular-weight range of heparins by using an electrofocusing procedure to isolate individual molecular species. ...The molecular-weight range of the heparin was observed to be broader than that usually reported....
A recently reported method describes the determination of the molecular-weight range of heparins by using an electrofocusing p …
A label-free diffraction-based sensing displacement immunosensor to quantify low molecular weight organic compounds.
Avella-Oliver M, et al. Anal Chim Acta 2018. PMID 30172323
Herein we present a diffractometric immunosensor to quantify low molecular weight organic compounds in a label-free, simple, and sensitive fashion. ...From a general viewpoint, this study also aims to provide insights into exploiting this approach towards prospective in-field analysis and screening strategies to sense multiple low molecular weight compounds in label-free conditions....
Herein we present a diffractometric immunosensor to quantify low molecular weight organic compounds in a label-free, simple, a …
153,181 results
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