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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 13
1946 16
1947 46
1948 53
1949 47
1950 77
1951 69
1952 71
1953 71
1954 85
1955 101
1956 105
1957 98
1958 86
1959 106
1960 86
1961 100
1962 106
1963 230
1964 308
1965 223
1966 217
1967 237
1968 297
1969 285
1970 288
1971 338
1972 350
1973 489
1974 509
1975 525
1976 528
1977 546
1978 562
1979 592
1980 666
1981 701
1982 805
1983 779
1984 832
1985 857
1986 854
1987 748
1988 753
1989 766
1990 816
1991 795
1992 769
1993 849
1994 805
1995 827
1996 798
1997 753
1998 770
1999 731
2000 817
2001 724
2002 691
2003 840
2004 798
2005 920
2006 924
2007 860
2008 940
2009 906
2010 897
2011 863
2012 873
2013 824
2014 869
2015 799
2016 786
2017 731
2018 677
2019 339
2020 2
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37,838 results
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Page 1
Morphine Zwitterion.
Alston TA. J Anesth Hist 2017. PMID 28641830
Stable isotope-labelled morphine to study in vivo central and peripheral morphine glucuronidation and brain transport in tolerant mice.
Weinsanto I, et al. Br J Pharmacol 2018. PMID 30051501 Free PMC article.
On the ninth day, both groups received a final injection of morphine (85%) and d3-morphine (morphine bearing three (2) H; 15%, w/w). ...Interestingly, d3-morphine metabolism was decreased compared to morphine without any interference with our study. CONCLUSIONS AND IMPLICATIONS: Our data suggests that tolerance to the analgesic effects of morphine is not linked to increased glucuronidation to M3G or to altered global BBB permeability of morphine....
On the ninth day, both groups received a final injection of morphine (85%) and d3-morphine (morphine bearing three (2) …
[Morphine in the treatment of acute pulmonary oedema].
Ellingsrud C and Agewall S. Tidsskr Nor Laegeforen 2014 - Review. PMID 25492336 Norwegian. Free article.
Vasodilation caused by morphine has been described in other patient groups, but there is little evidence in the literature to suggest that morphine causes vasodilation in patients with pulmonary oedema. ...There are no reliable clinical studies that document better prognosis from the use of morphine. INTERPRETATION: Based on the available studies, the possibility cannot be excluded that the use of morphine results in increased mortality among patients with acute pulmonary oedema. ...
Vasodilation caused by morphine has been described in other patient groups, but there is little evidence in the literature to suggest …
Total Synthesis of (-)-Morphine.
Umihara H, et al. Chemistry 2017. PMID 28378531
Asymmetric total synthesis of (-)-morphine has been accomplished in 18 steps from commercially available 7-methoxy-2-tetralone. ...
Asymmetric total synthesis of (-)-morphine has been accomplished in 18 steps from commercially available 7-methoxy-2-tetralone. ...
Serum and urine concentrations of morphine and morphine metabolites in patients with advanced cancer receiving continuous intravenous morphine: an observational study.
Lee YJ, et al. BMC Palliat Care 2015 - Clinical Trial. PMID 26507979 Free PMC article.
BACKGROUND: The feasibility and clinical implication of drug monitoring of morphine, morphine-6-glucuronide (M6G) and morphine-3-glucuronide (M3G) need further investigation. ...Median dose of morphine was 82.0 mg/24 h. In a multivariate analysis, total daily morphine dose was the most significant predictors of both serum and urine concentration of morphine. ...
BACKGROUND: The feasibility and clinical implication of drug monitoring of morphine, morphine-6-glucuronide (M6G) and morph
Intrathecal morphine in mice: a new technique.
Hylden JL and Wilcox GL. Eur J Pharmacol 1980. PMID 6893963
Intrathecal [3H]morphine base was not found in significant quantities in either the midbrain or forebrain. Submicrogram quantities of morphine sulfate induced Straub tail response and tail-flick analgesia. ...
Intrathecal [3H]morphine base was not found in significant quantities in either the midbrain or forebrain. Submicrogram quantities of …
Morphine: new aspects in the study of an ancient compound.
Benyhe S. Life Sci 1994 - Review. PMID 8084213
Nevertheless, consideration of morphine as endogenous ligand for opioid receptors seems to be speculative. Recently, the primary receptor for morphine-type drugs called the mu-opioid receptor has been cloned from rat brain. There is accumulating evidence that morphine actions are, at least partly, due to one of its major metabolite morphine-6-glucuronide in man. ...
Nevertheless, consideration of morphine as endogenous ligand for opioid receptors seems to be speculative. Recently, the primary rece …
Stability and compatibility of morphine.
Vermeire A and Remon JP. Int J Pharm 1999 - Review. PMID 10502612
Morphine degrades in aqueous solutions with the formation of mainly pseudomorphine, to a lesser extent morphine-N-oxide and probably apomorphine. ...The data reported on the stability of morphine infusion solutions kept under ambient conditions indicated that oxygen, light, the type of reservoir, the type of diluent, the salt form and the concentration of morphine do not affect the stability of morphine solutions stored for up to 3 months. ...
Morphine degrades in aqueous solutions with the formation of mainly pseudomorphine, to a lesser extent morphine-N-oxide and pr
Oral morphine in chronic cancer pain.
Walsh TD. Pain 1984 - Review. PMID 6200818
Specifically in the case of morphine it is clear that: it is a very effective analgesic given orally, dosage must be individualized, parenteral use or exotic analgesic 'cocktails' are usually unnecessary, and tolerance, dependence and respiratory depression are rarely common or serious problems which prevent effective pain control provided morphine is used appropriately in accordance with its pharmacological characteristics. Heroin is a suitable alternative to morphine (particularly for intramuscular administration) if differences in milligram potency are taken into account, but has no advantages in terms of either analgesic efficacy or side effects. ...
Specifically in the case of morphine it is clear that: it is a very effective analgesic given orally, dosage must be individualized, …
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