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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1964 1
1965 7
1966 19
1967 17
1968 25
1969 20
1970 14
1971 10
1972 23
1973 17
1974 21
1975 21
1976 16
1977 24
1978 22
1979 17
1980 20
1981 17
1982 32
1983 20
1984 23
1985 32
1986 30
1987 28
1988 15
1989 17
1990 40
1991 35
1992 39
1993 42
1994 47
1995 53
1996 66
1997 53
1998 59
1999 57
2000 48
2001 39
2002 57
2003 52
2004 42
2005 52
2006 49
2007 45
2008 39
2009 68
2010 63
2011 68
2012 56
2013 55
2014 52
2015 42
2016 47
2017 45
2018 37
2019 18
2020 0
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1,861 results
Results by year
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Page 1
Chemical conversion of human and mouse fibroblasts into motor neurons.
Qin H, et al. Sci China Life Sci 2018. PMID 30159682
Transplantation of motor neurons can provide long-term functional benefits in animal models of neurodegenerative motor neuron diseases such as amyotrophic lateral sclerosis and traumatic spinal cord injury. Although embryonic stem cells can differentiate into motor neurons, alternative sources of motor neurons may be controllable for disease modeling and transplantation. ...
Transplantation of motor neurons can provide long-term functional benefits in animal models of neurodegenerative motor
Incorporating upper motor neuron health in ALS drug discovery.
Dervishi I and Ozdinler PH. Drug Discov Today 2018 - Review. PMID 29331501 Free PMC article.
Amyotrophic lateral sclerosis (ALS) is a complex disease, that affects the motor neuron circuitry. After consecutive failures in clinical trials for the past 20 years, edaravone was recently approved as the second drug for ALS. ...Here, we focus on the importance and relevance of upper motor neuron (UMN) pathology in ALS, and discuss how incorporation of UMN survival in preclinical assays will improve inclusion criteria for clinical trials and expedite the drug discovery effort in ALS and related motor neuron diseases....
Amyotrophic lateral sclerosis (ALS) is a complex disease, that affects the motor neuron circuitry. After consecutive failures in clin …
In vivo neurotrophic effects of GDNF on neonatal and adult facial motor neurons.
Yan Q, et al. Nature 1995. PMID 7830768
Here we investigate the potential motor neuron neurotrophic effects of glial-cell-line-derived neurotrophic factor (GDNF), initially identified as a neurotrophic factor for substantia nigra dopaminergic neurons. ...Our data indicate that GDNF has very profound neurotrophic effects in vivo on developing as well as on adult motor neurons, and is the most potent motor neuron trophic factor found so far....
Here we investigate the potential motor neuron neurotrophic effects of glial-cell-line-derived neurotrophic factor (GDNF), ini …
Taurine Protects Glutamate Neurotoxicity in Motor Neuron Cells.
Lee NY and Kang YS. Adv Exp Med Biol 2017. PMID 28849508
Therefore, in the present study, we investigated neuroprotective effects of taurine from glutamate excitotoxicity using motor neuron cells, mtSOD1 (G93A) transgenic cell line model of ALS (NSC-34/hSOD1G93A cells). We evidenced that taurine protects cultured motor neurons from neurotoxic injury. Our findings indicated that taurine has neuroprotective properties and may be a good candidate for therapeutic trials in ALS....
Therefore, in the present study, we investigated neuroprotective effects of taurine from glutamate excitotoxicity using motor
Selective vulnerability of spinal motor neurons to reactive dicarbonyl compounds, intermediate products of glycation, in vitro: implication of inefficient glutathione system in spinal motor neurons.
Shinpo K, et al. Brain Res 2000. PMID 10751575
We investigated the effects of two reactive dicarbonyl compounds, methylglyoxal (MG) and 3-deoxyglucosone (3-DG), on cultured spinal cord neurons. ...Treatments with glutathione (GSH)-augmenting agents showed protective effects against MG and 3-DG neurotoxicity. Motor neurons were better protected than non-motor neurons. ...
We investigated the effects of two reactive dicarbonyl compounds, methylglyoxal (MG) and 3-deoxyglucosone (3-DG), on cultured spinal …
Glucocorticoid effects on the electrical properties of spinal motor neurons.
Hall ED. Brain Res 1982. PMID 7093711
The effects of an intensive 7 day glucocorticoid (e.g. methylprednisolone) regimen have been studied on the electrical properties of cat lumbar spinal motor neurons via intracellular recording. The results reported in this paper have shown that glucocorticoid dosing produces numerous effects on motor neuron excitability and impulse generation and conduction. ...
The effects of an intensive 7 day glucocorticoid (e.g. methylprednisolone) regimen have been studied on the electrical properties of …
Effect of 5-HT2A receptor antagonist ketanserin on micturition in male rats
Wang X, et al. Neurosci Lett 2018. PMID 30278246
Immunofluorescence staining and Western blotting were made to observe the distribution of 5-HT2 A and -2C receptors in the lumbosacral cord motor neurons. ...The effects of ketanserin on the HFO and EUS-EMG activity were partially or completely reversed by the 5-HT(2A/2C) receptor agonist, DOI. ...
Immunofluorescence staining and Western blotting were made to observe the distribution of 5-HT2 A and -2C receptors in the lumbosacral cord …
G-protein-coupled receptor 30-mediated antiapoptotic effect of estrogen on spinal motor neurons following injury and its underlying mechanisms.
Chen J, et al. Mol Med Rep 2015. PMID 25872489 Free PMC article.
The effects of estrogen, the estrogen agonist, G1, and the estrogen inhibitor, G15, on motor neurons were observed using MTT assays. ...Estrogen thus appears to exert a protective effect on spinal motor neurons following OGD, via GPR30. The PI3K/Akt pathway may be one of those involved in the estrogen‑related antiapoptotic effects mediated by GPR30....
The effects of estrogen, the estrogen agonist, G1, and the estrogen inhibitor, G15, on motor neurons were observed usin …
Analysis of neuroprotective effects of valproic acid on primary motor neurons in monoculture or co-cultures with astrocytes or Schwann cells.
Ragancokova D, et al. Cell Mol Neurobiol 2009. PMID 19330445
We investigated the viability of highly purified rat embryonic motor neurons cultured on glial feeder layers, composed of either astrocytes or Schwann cells, or in the absence of glia, monoculture in presence of VPA and/or kainate (KA) using immunocytochemistry and calcium imaging. A significant effect of the culture and co-culture conditions on the viability of motor neurons in our in vitro model of excitotoxicity was detected. ...
We investigated the viability of highly purified rat embryonic motor neurons cultured on glial feeder layers, composed of eith …
Effects of metal exposure on motor neuron development, neuromasts and the escape response of zebrafish embryos.
Sonnack L, et al. Neurotoxicol Teratol 2015. PMID 26006317
Motor neuron damage was investigated by immunofluorescence staining of primary motor neurons (PMNs) and secondary motor neurons (SMNs). ...The median effective concentration (EC50) values for morphological effects 72 h post fertilization (hpf) were 14.6 mg/L for cadmium and 0.018 mg/L for copper, whereas embryos exposed up to 45.8 mg/L cobalt showed no morphological effects. ...
Motor neuron damage was investigated by immunofluorescence staining of primary motor neurons (PMNs) and secondary mo
1,861 results
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