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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1982 1
1983 6
1984 21
1985 15
1986 15
1987 23
1988 27
1989 51
1990 19
1991 37
1992 33
1993 58
1994 42
1995 48
1996 73
1997 39
1998 45
1999 24
2000 55
2001 51
2002 62
2003 57
2004 45
2005 40
2006 52
2007 57
2008 57
2009 56
2010 67
2011 58
2012 42
2013 65
2014 68
2015 59
2016 37
2017 33
2018 36
2019 19
2020 0
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1,502 results
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Page 1
Mechanisms of Organ Dysfunction in Sepsis.
Pool R, et al. Crit Care Clin 2018 - Review. PMID 29149942 Free PMC article.
Sepsis-associated organ dysfunction involves multiple responses to inflammation, including endothelial and microvascular dysfunction, immune and autonomic dysregulation, and cellular metabolic reprogramming. ...
Sepsis-associated organ dysfunction involves multiple responses to inflammation, including endothelial and microvascular dysfu …
Abdominal Compartment Hypertension and Abdominal Compartment Syndrome
Maluso P, et al. Crit Care Clin 2016 - Review. PMID 27016163
Left untreated, ACS can lead to multisystem organ failure and death....
Left untreated, ACS can lead to multisystem organ failure and death....
[Pathophysiology of sepsis]
Uhle F, et al. Anasthesiol Intensivmed Notfallmed Schmerzther 2015 - Review. PMID 25723606 German.
Multiple organ failure: a common problem in surgical intensive care unit patients.
Livingston DH and Deitch EA. Ann Med 1995 - Review. PMID 7741992
The management of the surgical patient with multiple system organ failure remains a formidable problem. Despite advances in critical care, the mortality of multiple organ failure remains unchanged since the syndrome was characterized almost two decades ago. ...This review will examine the current theories in the pathogenesis of multiple organ failure and detail two clinical decisions, early stabilization of fractures and prompt re-exploration for suspected abdominal sepsis, that have been associated with a reduction in the frequency of the development of organ failure....
The management of the surgical patient with multiple system organ failure remains a formidable problem. Despite advance …
The Gut as the Motor of Multiple Organ Dysfunction in Critical Illness.
Klingensmith NJ and Coopersmith CM. Crit Care Clin 2016 - Review. PMID 27016162 Free PMC article.
All elements of the gut - the epithelium, the immune system, and the microbiome - are impacted by critical illness and can, in turn, propagate a pathologic host response leading to multiple organ dysfunction syndrome. ...Gut failure is common in critically ill patients; however, therapeutics targeting the gut have proven to be challenging to implement at the bedside. ...
All elements of the gut - the epithelium, the immune system, and the microbiome - are impacted by critical illness and can, in turn, propaga …
Multiple organ failure, multiple organ dysfunction syndrome, and systemic inflammatory response syndrome. Why no magic bullets?
Baue AE. Arch Surg 1997 - Review. PMID 9230852
The concept of multiple organ failure and related abnormalities was first developed in the 1970s. Multiple organ failure became evident when the support systems in intensive care units were able to keep patients alive long enough for multiple organ problems to develop in them. The high mortality of patients with multiple organ failure provided a focus for the problems that ultimately led to death for many patients in the intensive care unit. ...
The concept of multiple organ failure and related abnormalities was first developed in the 1970s. Multiple or
Multiple organ failure syndrome.
Cerra FB. Dis Mon 1992 - Review. PMID 1478149
The systemic responses include shock, reperfusion, systemic inflammation (hypermetabolism) with primary organ dysfunction, and secondary organ dysfunction that either becomes progressive and leads to death or from which the patient recovers and enters into a period of prolonged rehabilitation. ...The research indicates that the responses may contribute to the development of cell and organ injury and to progressive multiple organ failure syndrome and death, particularly in the case of the systemic inflammatory response. ...
The systemic responses include shock, reperfusion, systemic inflammation (hypermetabolism) with primary organ dysfunction, and second …
Sepsis, mitochondrial failure and multiple organ dysfunction.
Duran-Bedolla J, et al. Clin Invest Med 2014 - Review. PMID 24690420
PURPOSE: The purpose of this review is to consider the state of oxidative stress, failure of the antioxidant systems and mitochondrial failure as the main physiopathological mechanisms leading to multiple organ dysfunction during sepsis. ...The loss of the redox balance, together with a systemic inflammatory response during sepsis, can lead to progressive and irreversible mitochondrial failure, energy depletion, hypoxia, septic shock, severe sepsis, multiple organ dysfunction and death of the patient. ...
PURPOSE: The purpose of this review is to consider the state of oxidative stress, failure of the antioxidant systems and mitochondria …
Multiple system organ failure.
Fry DE. Surg Clin North Am 1988 - Review. PMID 3277299
Multiple system organ failure represents the final common pathway to a fatal outcome in severely infected patients. Despite the development of extensive support technology, the mortality rate in this group of patients remains high: in excess of 50 per cent. ...
Multiple system organ failure represents the final common pathway to a fatal outcome in severely infected patients. Des
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