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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1964 1
1978 1
1981 3
1982 1
1984 1
1986 1
1987 2
1988 2
1989 1
1990 1
1991 5
1992 6
1993 7
1994 5
1995 2
1996 12
1997 19
1998 18
1999 25
2000 24
2001 39
2002 74
2003 78
2004 365
2005 860
2006 906
2007 917
2008 884
2009 935
2010 1025
2011 1107
2012 1212
2013 1393
2014 1253
2015 1338
2016 1154
2017 829
2018 570
2019 239
2020 1
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13,748 results
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Page 1
A multiprotein supercomplex controlling oncogenic signalling in lymphoma.
Phelan JD, et al. Nature 2018. PMID 29925955 Free PMC article.
We discovered a new mode of oncogenic BCR signalling in ibrutinib-responsive cell lines and biopsies, coordinated by a multiprotein supercomplex formed by MYD88, TLR9 and the BCR (hereafter termed the My-T-BCR supercomplex). ...
We discovered a new mode of oncogenic BCR signalling in ibrutinib-responsive cell lines and biopsies, coordinated by a multiprotein s …
Structures, Functions, and Dynamics of ESCRT-III/Vps4 Membrane Remodeling and Fission Complexes.
McCullough J, et al. Annu Rev Cell Dev Biol 2018 - Review. PMID 30095293 Free PMC article.
The endosomal sorting complexes required for transport (ESCRT) pathway mediates cellular membrane remodeling and fission reactions. The pathway comprises five core complexes: ALIX, ESCRT-I, ESCRT-II, ESCRT-III, and Vps4. These soluble complexes are typically recruited to target membranes by site-specific adaptors that bind one or both of the early-acting ESCRT factors: ALIX and ESCRT-I/ESCRT-II. ...
The endosomal sorting complexes required for transport (ESCRT) pathway mediates cellular membrane remodeling and fission reactions. T …
Cotranslational assembly of protein complexes in eukaryotes revealed by ribosome profiling.
Shiber A, et al. Nature 2018. PMID 30158700 Free PMC article.
Here we provide a systematic and mechanistic analysis of the assembly of protein complexes in eukaryotes using ribosome profiling. ...We find nine complexes assemble cotranslationally; the three complexes that do not show cotranslational interactions are regulated by dedicated assembly chaperones(5-7). ...
Here we provide a systematic and mechanistic analysis of the assembly of protein complexes in eukaryotes using ribosome profiling. .. …
Towards a Unified Model of SMC Complex Function
Hassler M, et al. Curr Biol 2018 - Review. PMID 30399354 Free PMC article.
Protein complexes built of structural maintenance of chromosomes (SMC) and kleisin subunits, including cohesin, condensin and the Smc5/6 complex, are master organizers of genome architecture in all kingdoms of life. ...Here, we review the current knowledge about the biochemical and structural properties of SMC protein complexes that might enable them to extrude DNA loops and compare their action to other motor proteins and nucleic acid translocases. ...
Protein complexes built of structural maintenance of chromosomes (SMC) and kleisin subunits, including cohesin, condensin and the Smc …
Complex-centric proteome profiling by SEC-SWATH-MS
Heusel M, et al. Mol Syst Biol 2019. PMID 30642884 Free PMC article.
The organization of proteins into macromolecular complexes and their quantitative distribution across these complexes is, therefore, of great biological and clinical significance. ...Our analysis of the HEK293 cell line proteome delineates 462 complexes composed of 2,127 protein subunits. The technique identifies novel sub-complexes and assembly intermediates of central regulatory complexes while assessing the quantitative subunit distribution across them. ...
The organization of proteins into macromolecular complexes and their quantitative distribution across these complexes is, ther …
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