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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 10
1946 74
1947 64
1948 85
1949 61
1950 79
1951 81
1952 57
1953 70
1954 59
1955 64
1956 72
1957 75
1958 88
1959 100
1960 120
1961 169
1962 209
1963 652
1964 1401
1965 1084
1966 942
1967 1177
1968 1267
1969 1446
1970 1573
1971 1573
1972 1593
1973 1827
1974 2296
1975 2128
1976 1811
1977 1579
1978 1483
1979 1736
1980 1495
1981 1819
1982 2066
1983 2230
1984 2511
1985 2526
1986 2839
1987 3035
1988 3359
1989 3927
1990 4313
1991 3565
1992 4077
1993 4804
1994 5403
1995 5729
1996 5816
1997 6133
1998 7136
1999 6939
2000 7490
2001 7672
2002 7376
2003 7957
2004 8722
2005 9412
2006 9827
2007 10274
2008 10592
2009 10376
2010 10938
2011 11821
2012 12360
2013 12769
2014 12933
2015 13346
2016 12608
2017 11670
2018 11359
2019 5263
2020 106
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289,852 results
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Page 1
The mechanisms of UV mutagenesis
Ikehata H and Ono T. J Radiat Res 2011 - Review. PMID 21436607 Free article.
Daylight UV induces a characteristic UV-specific mutation, a UV-signature mutation occurring preferentially at methyl-CpG sites, which is also observed frequently after exposure to either UVB or UVA, but not to UVC. The wavelengths relevant to the mutation are so consistent with the composition of daylight UV that the mutation is called solar-UV signature, highlighting the importance of this type of mutation for creatures with the cytosine-methylated genome that are exposed to the sun in the natural environment. ...
Daylight UV induces a characteristic UV-specific mutation, a UV-signature mutation occurring preferentially at methyl-CpG site …
Detecting Somatic Mutations in Normal Cells
Dou Y, et al. Trends Genet 2018 - Review. PMID 29731376 Free PMC article.
We discuss several experimental designs and common pitfalls in somatic mutation detection, as well as more recent developments such as phasing and linked-read technology. ...
We discuss several experimental designs and common pitfalls in somatic mutation detection, as well as more recent developments such a …
Repeat instability: mechanisms of dynamic mutations
Pearson CE, et al. Nat Rev Genet 2005 - Review. PMID 16205713
Disease-causing repeat instability is an important and unique form of mutation that is linked to more than 40 neurological, neurodegenerative and neuromuscular disorders. ...
Disease-causing repeat instability is an important and unique form of mutation that is linked to more than 40 neurological, neurodege …
Mutation rates and the evolution of germline structure.
Scally A. Philos Trans R Soc Lond B Biol Sci 2016. PMID 27325834 Free PMC article.
Genome sequencing studies of de novo mutations in humans have revealed surprising incongruities in our understanding of human germline mutation. ...More generally, I argue that the mutation rate and its evolution depend intimately on the structure of the germline in humans and other primates.This article is part of the themed issue 'Dating species divergences using rocks and clocks'....
Genome sequencing studies of de novo mutations in humans have revealed surprising incongruities in our understanding of human germline mu
Linked-read analysis identifies mutations in single-cell DNA-sequencing data
Bohrson CL, et al. Nat Genet 2019. PMID 30886424 Free PMC article.
Here, we describe linked-read analysis (LiRA), a method that accurately identifies somatic single-nucleotide variants (sSNVs) by using read-level phasing with nearby germline heterozygous polymorphisms, thereby enabling the characterization of mutational signatures and estimation of somatic mutation rates in single cells....
Here, we describe linked-read analysis (LiRA), a method that accurately identifies somatic single-nucleotide variants (sSNVs) by using read- …
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