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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 10
1946 74
1947 64
1948 85
1949 61
1950 79
1951 81
1952 57
1953 70
1954 59
1955 64
1956 72
1957 75
1958 88
1959 100
1960 120
1961 169
1962 209
1963 658
1964 1445
1965 1362
1966 1519
1967 2056
1968 2564
1969 2932
1970 3208
1971 3537
1972 3845
1973 4227
1974 4769
1975 4463
1976 4015
1977 3882
1978 3673
1979 4094
1980 3937
1981 3982
1982 4378
1983 4650
1984 5030
1985 5598
1986 5795
1987 6244
1988 7145
1989 8620
1990 9657
1991 8747
1992 9496
1993 11277
1994 13238
1995 14820
1996 15364
1997 15692
1998 17770
1999 18622
2000 20792
2001 22245
2002 22111
2003 23740
2004 25540
2005 27053
2006 27816
2007 28190
2008 29032
2009 28669
2010 30101
2011 31685
2012 32636
2013 33953
2014 33239
2015 33418
2016 32820
2017 32073
2018 30385
2019 14146
2020 230
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747,034 results
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Page 1
Measuring intolerance to mutation in human genetics.
Fuller ZL, et al. Nat Genet 2019 - Review. PMID 30962618 Free PMC article.
In numerous applications, from working with animal models to mapping the genetic basis of human disease susceptibility, knowing whether a single disrupting mutation in a gene is likely to be deleterious is useful. With this goal in mind, a number of measures have been developed to identify genes in which protein-truncating variants (PTVs), or other types of mutations, are absent or kept at very low frequency in large population samples-genes that appear 'intolerant' to mutation. ...
In numerous applications, from working with animal models to mapping the genetic basis of human disease susceptibility, knowing whether a si …
Universal Patterns of Selection in Cancer and Somatic Tissues
Martincorena I, et al. Cell 2017. PMID 29056346 Free PMC article.
Cancer develops as a result of somatic mutation and clonal selection, but quantitative measures of selection in cancer evolution are lacking. ...With increasing mutation burden, numbers of driver mutations increase, but not linearly. We systematically catalog cancer genes and show that genes vary extensively in what proportion of mutations are drivers versus passengers....
Cancer develops as a result of somatic mutation and clonal selection, but quantitative measures of selection in cancer evolution are …
Toward a Unique Definition of the Mutation Rate.
Zheng Q. Bull Math Biol 2017. PMID 28213725
As a result, researchers and educators alike are still grappling with the definition of the mutation rate. Within the context of microbial mutation, the current author proposes an idealized model to bring new clarity to the distinction between the two forms of the mutation rate that Delbrück once attempted to define and characterize. The paper also critiques two incorrect estimators of mutation rates and brings to light two important yet unexplored "invariance" hypotheses about mutation rates....
As a result, researchers and educators alike are still grappling with the definition of the mutation rate. Within the context of micr …
Mutation accumulation under UV radiation in Escherichia coli.
Shibai A, et al. Sci Rep 2017. PMID 29109412 Free PMC article.
Here, we explored the mutation profiles of UV radiation, a ubiquitous mutagen, in Escherichia coli on the genomic scale. We performed an evolution experiment under periodic UV radiation for 28 days. ...
Here, we explored the mutation profiles of UV radiation, a ubiquitous mutagen, in Escherichia coli on the genomic scale. We performed …
Repeat instability: mechanisms of dynamic mutations
Pearson CE, et al. Nat Rev Genet 2005 - Review. PMID 16205713
Disease-causing repeat instability is an important and unique form of mutation that is linked to more than 40 neurological, neurodegenerative and neuromuscular disorders. ...
Disease-causing repeat instability is an important and unique form of mutation that is linked to more than 40 neurological, neurodege …
747,034 results
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