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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1964 1
1979 1
1980 5
1981 14
1982 25
1983 28
1984 33
1985 61
1986 99
1987 130
1988 179
1989 264
1990 376
1991 390
1992 433
1993 465
1994 478
1995 440
1996 453
1997 398
1998 426
1999 404
2000 385
2001 330
2002 328
2003 336
2004 329
2005 362
2006 346
2007 308
2008 299
2009 304
2010 286
2011 265
2012 296
2013 227
2014 192
2015 202
2016 166
2017 161
2018 121
2019 58
2020 1
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9,927 results
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Page 1
Postoperative Multimodal Analgesia Pain Management With Nonopioid Analgesics and Techniques: A Review
Wick EC, et al. JAMA Surg 2017 - Review. PMID 28564673
OBSERVATIONS: Regional analgesia, acetaminophen, nonsteroidal anti-inflammatory agents, gabapentinoids, tramadol, lidocaine, and/or the N-methyl-d-aspartate class of glutamate receptor antagonists have been shown to be effective adjuncts to narcotic analgesia. ...
OBSERVATIONS: Regional analgesia, acetaminophen, nonsteroidal anti-inflammatory agents, gabapentinoids, tramadol, lidocaine, and/or the N
Cannabidiol enhances morphine antinociception, diminishes NMDA-mediated seizures and reduces stroke damage via the sigma 1 receptor
Rodríguez-Muñoz M, et al. Mol Brain 2018. PMID 30223868 Free PMC article.
Notably, sigma 1 receptor (σ1R) antagonists inhibit glutamate N-methyl-D-aspartate acid receptor (NMDAR) activity and display positive effects on most of the aforesaid diseases. ...
Notably, sigma 1 receptor (σ1R) antagonists inhibit glutamate N-methyl-D-aspartate acid receptor (NMDAR) activity and display positiv …
BDNF release and signaling are required for the antidepressant actions of GLYX-13
Kato T, et al. Mol Psychiatry 2018. PMID 29203848 Free PMC article.
GLYX-13 is a novel glutamatergic compound that acts as an N-methyl-D-aspartate (NMDA) modulator with glycine-like partial agonist properties; like the NMDA receptor antagonist ketamine GLYX-13 produces rapid antidepressant actions in depressed patients and in preclinical rodent models. ...
GLYX-13 is a novel glutamatergic compound that acts as an N-methyl-D-aspartate (NMDA) modulator with glycine-like partial agonist pro …
De novo mutations in GRIN1 cause extensive bilateral polymicrogyria
Fry AE, et al. Brain 2018. PMID 29365063 Free PMC article.
These results are striking because previous GRIN1 mutations have generally caused loss of function, and because N-methyl-d-aspartate receptor agonists have been used for many years to generate animal models of polymicrogyria. Overall, our results expand the phenotypic spectrum associated with GRIN1 mutations and highlight the important role of N-methyl-d-aspartate receptor signalling in the pathogenesis of polymicrogyria....
These results are striking because previous GRIN1 mutations have generally caused loss of function, and because N-methyl-d-aspartate …
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