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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1995 2
1996 28
1997 44
1998 43
1999 53
2000 49
2001 74
2002 97
2003 103
2004 140
2005 178
2006 205
2007 233
2008 237
2009 277
2010 278
2011 285
2012 312
2013 310
2014 298
2015 323
2016 282
2017 294
2018 239
2019 133
2020 2
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3,935 results
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NADPH oxidases and cancer.
Roy K, et al. Clin Sci (Lond) 2015 - Review. PMID 25818486
The mechanism by which reactive oxygen species (ROS) are produced by tumour cells remained incompletely understood until the discovery over the last 15 years of the family of NADPH oxidases (NOXs 1-5 and dual oxidases DUOX1/2) which are structural homologues of gp91phox, the major membrane-bound component of the respiratory burst oxidase of leucocytes. ...
The mechanism by which reactive oxygen species (ROS) are produced by tumour cells remained incompletely understood until the discovery over …
NADPH oxidases in Parkinson's disease: a systematic review.
Belarbi K, et al. Mol Neurodegener 2017 - Review. PMID 29132391 Free PMC article.
Increased immunoreactivities for the NADPH oxidases catalytic subunits Nox1, Nox2 and Nox4 have been reported in the brain of PD patients. ...Furthermore, this review highlights different steps that are essential for NADPH oxidases enzymatic activity and pinpoints major obstacles to overcome for the development of effective NADPH oxidases inhibitors for PD....
Increased immunoreactivities for the NADPH oxidases catalytic subunits Nox1, Nox2 and Nox4 have been reported in the brain of …
The Role of NADPH Oxidases and Oxidative Stress in Neurodegenerative Disorders.
Tarafdar A and Pula G. Int J Mol Sci 2018 - Review. PMID 30513656 Free PMC article.
For a number of years, nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOX) was synonymous with NOX2/gp91(phox) and was considered to be a peculiarity of professional phagocytic cells. ...Elevated ROS leads to oxidative stress (OS), which has been associated with a myriad of inflammatory and degenerative pathologies. ...
For a number of years, nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOX) was synonymous with NOX2/gp91(phox) …
Regulation of NADPH oxidases in skeletal muscle.
Ferreira LF and Laitano O. Free Radic Biol Med 2016 - Review. PMID 27184955 Free PMC article.
The only known function of NAD(P)H oxidases is to produce reactive oxygen species (ROS). Skeletal muscles express three isoforms of NAD(P)H oxidases (Nox1, Nox2, and Nox4) that have been identified as critical modulators of redox homeostasis. ...Our review addresses the expression and regulation of NAD(P)H oxidases with emphasis on aspects that are relevant to skeletal muscle. ...
The only known function of NAD(P)H oxidases is to produce reactive oxygen species (ROS). Skeletal muscles express three isoforms of N …
NADPH oxidases and ROS signaling in the gastrointestinal tract.
Aviello G and Knaus UG. Mucosal Immunol 2018 - Review. PMID 29743611
NOX/DUOX NADPH oxidases are the only enzymes solely dedicated to ROS production and the prime ROS producer for intracellular and intercellular communication due to their widespread expression and intricate regulation. Here we discuss new insights of how NADPH oxidases act via ROS as multifaceted regulators of the intestinal barrier in homeostasis, infectious disease and intestinal inflammation. ...
NOX/DUOX NADPH oxidases are the only enzymes solely dedicated to ROS production and the prime ROS producer for intracellular a …
NADPH Oxidases and Their Roles in Skin Homeostasis and Carcinogenesis.
Rudolf J, et al. Antioxid Redox Signal 2018 - Review. PMID 28990413
However, continuous (re)activation of NADPH oxidases can disturb the redox balance of cells, in the worst-case scenario in a permanent manner. Abnormal NADPH oxidase activity has been associated with a wide spectrum of diseases, as well as with aging and carcinogenesis. ...
However, continuous (re)activation of NADPH oxidases can disturb the redox balance of cells, in the worst-case scenario in a p …
Nox family NADPH oxidases: Molecular mechanisms of activation.
Brandes RP, et al. Free Radic Biol Med 2014 - Review. PMID 25157786
NADPH oxidases of the Nox family are important enzymatic sources of reactive oxygen species (ROS). Numerous homologue-specific mechanisms control the activity of this enzyme family involving calcium, free fatty acids, protein-protein interactions, intracellular trafficking, and posttranslational modifications such as phosphorylation, acetylation, or sumoylation. ...
NADPH oxidases of the Nox family are important enzymatic sources of reactive oxygen species (ROS). Numerous homologue-specific
NADPH oxidases and vascular remodeling in cardiovascular diseases.
García-Redondo AB, et al. Pharmacol Res 2016 - Review. PMID 27773825
A misbalance between the production and detoxification of ROS increases oxidative stress that is involved in the vascular remodeling associated with cardiovascular diseases such as hypertension by affecting inflammation, hypertrophy, migration, growth/apoptosis and extracellular matrix protein turnover. The major and more specific source of ROS in the cardiovascular system is the NADPH oxidase (NOX) family of enzymes composed of seven members (NOX1-5, DUOX 1/2). ...
A misbalance between the production and detoxification of ROS increases oxidative stress that is involved in the vascular remodeling …
NADPH oxidases in bone homeostasis and osteoporosis.
Schröder K. Free Radic Biol Med 2019 - Review. PMID 30189265
Importantly the members of the NADPH oxidase family differ in their localization and in the type and amount of ROS produced. ...This review will highlight the function of different NADPH oxidases in differentiation and function of bone cells and thereby will discuss the role of NADPH oxidases in bone homeostasis and osteoporosis....
Importantly the members of the NADPH oxidase family differ in their localization and in the type and amount of ROS produced. . …
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