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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1990 21
1991 60
1992 117
1993 191
1994 255
1995 347
1996 403
1997 522
1998 660
1999 930
2000 1118
2001 1379
2002 1531
2003 1693
2004 1987
2005 2183
2006 2406
2007 2514
2008 2785
2009 2961
2010 3162
2011 3485
2012 3754
2013 3953
2014 3909
2015 4062
2016 3897
2017 3881
2018 3790
2019 1896
2020 30
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53,059 results
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Page 1
Preface. NF-kappa B.
May MJ. Methods Mol Biol 2015. PMID 25897435
The noncanonical NF-κB pathway.
Sun SC. Immunol Rev 2012 - Review. PMID 22435551 Free PMC article.
The noncanonical nuclear factor-κB (NF-κB) signaling pathway mediates activation of the p52/RelB NF-κB complex and, thereby, regulates specific immunological processes. This NF-κB pathway relies on the inducible processing of NF-κB2 precursor protein, p100, as opposed to the degradation of IκBα in the canonical NF-κB pathway. ...
The noncanonical nuclear factor-κB (NF-κB) signaling pathway mediates activation of the p52/RelB NF-κB complex and, thereby, r …
NF-κB and the Transcriptional Control of Inflammation.
Mitchell JP and Carmody RJ. Int Rev Cell Mol Biol 2018 - Review. PMID 29305014
The NF-κB transcription factor was discovered 30 years ago and has since emerged as the master regulator of inflammation and immune homeostasis. ...We also describe the emerging importance of posttranslational modifications of NF-κB in the regulation of inflammation, and highlight the future challenges faced by researchers who aim to target NF-κB transcriptional activity for therapeutic benefit in treating chronic inflammatory diseases....
The NF-κB transcription factor was discovered 30 years ago and has since emerged as the master regulator of inflammation and immune h …
Synaptic NF-kappa B pathway in neuronal plasticity and memory.
Salles A, et al. J Physiol Paris 2014 - Review. PMID 24854662
Several transcription factors are present at the synapse, and among these are the Rel-NF-kappa B pathway components. NF-kappa B is a constitutive transcription factor, with a strong presence in the brain of which a considerable part is located in the neuropiles. This localization of the transcription factor, plus evidence pointing to different functions, is what gave place to two general hypotheses for synaptic NF-kappa B: (a) The transcription factor plays a role in the synapse to nucleus communication, and it is retrogradely transported from polarized localizations to regulate gene expression; (b) The transcription factor modulates the synaptic function locally. ...
Several transcription factors are present at the synapse, and among these are the Rel-NF-kappa B pathway components. …
Signaling to NF-kappaB by Toll-like receptors.
Kawai T and Akira S. Trends Mol Med 2007 - Review. PMID 18029230
All TLR signaling pathways culminate in activation of the transcription factor nuclear factor-kappaB (NF-kappaB), which controls the expression of an array of inflammatory cytokine genes. ...Here, we review recent progress in our understanding of the role of NF-kappaB in TLR signaling pathways and discuss potential implications for molecular medicine....
All TLR signaling pathways culminate in activation of the transcription factor nuclear factor-kappaB (NF-kappaB), which controls the …
Introduction to NF-kappaB: players, pathways, perspectives.
Gilmore TD. Oncogene 2006 - Review. PMID 17072321
This article serves as an introduction to the collection of reviews on nuclear factor-kappaB (NF-kappaB). It provides an overview of the discovery and current status of NF-kappaB as a research topic. Described are the structures, activities and regulation of the proteins in the NF-kappaB family of transcription factors. NF-kappaB signaling is primarily regulated by inhibitor kappaB (IkappaB) proteins and the IkappaB kinase complex through two major pathways: the canonical and non-canonical NF-kappaB pathways. ...
This article serves as an introduction to the collection of reviews on nuclear factor-kappaB (NF-kappaB). It provides an overview of …
I kappa B-independent control of NF-kappa B activity by modulatory phosphorylations.
Schmitz ML, et al. Trends Biochem Sci 2001 - Review. PMID 11246025
Activation of the transcription factor nuclear factor kappa B (NF-kappa B) requires its release from inhibitor of NF-kappa B (I kappa B) proteins in the cytoplasm. ...Although their overall impact on NF-kappa B function has yet to be determined, modifications of this factor will very probably provide a mechanism to fine tune NF-kappa B function....
Activation of the transcription factor nuclear factor kappa B (NF-kappa B) requires its release from inhi …
Activation of NF-kappa B by reactive oxygen intermediates in the nervous system.
Kaltschmidt B, et al. Antioxid Redox Signal 1999 - Review. PMID 11228742
Nuclear factor kappa B (NF-kappa B) is a transcription factor crucially involved in glial and neuronal function. NF-kappa B is ubiquitously distributed within the nervous system, and its inducible activity can be discerned from constitutive activity. ...This activates translocation of NF-kappa B to the nucleus, where it binds to kappa B motifs of target genes and activates transcription. ...
Nuclear factor kappa B (NF-kappa B) is a transcription factor crucially involved in glial and neuronal fu …
Linear Energy Transfer Modulates Radiation-Induced NF-kappa B Activation and Expression of its Downstream Target Genes.
Chishti AA, et al. Radiat Res 2018. PMID 29369006
The maximal RBE for NF-κB activation and cell killing occurred at an LET value of 80 and 175 keV/μm, respectively. There was a dose-dependent increase in expression of NF-κB target genes NF-κB1A and CXCL8. A qPCR array of 84 NF-κB target genes revealed that TNF and a set of CXCL genes (CXCL1, CXCL2, CXCL8, CXCL10), CCL2, VCAM1, CD83, NF-κB1, NF-κB2 and NF-κBIA were strongly upregulated after exposure to X rays and neon ions (LET 92 keV/μm). ...
The maximal RBE for NF-κB activation and cell killing occurred at an LET value of 80 and 175 keV/μm, respectively. There was a dose-d …
Molecular basis of NF-κB signaling.
Napetschnig J and Wu H. Annu Rev Biophys 2013 - Review. PMID 23495970 Free PMC article.
NF-κB (nuclear factor kappa B) family transcription factors are master regulators of immune and inflammatory processes in response to both injury and infection. ...Here, we review the plethora of structural studies in these NF-κB activation pathways, including the TRAF (TNF receptor-associated factor) proteins, IKK, NF-κB, ubiquitin ligases, and deubiquitinating enzymes. ...
NF-κB (nuclear factor kappa B) family transcription factors are master regulators of immune and inflammatory processes
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