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1993 1
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1999 5
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2002 36
2003 37
2004 34
2005 65
2006 87
2007 95
2008 97
2009 103
2010 95
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2013 131
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2018 97
2019 32
2020 0
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NK cell receptor NKG2D sets activation threshold for the NCR1 receptor early in NK cell development.
Jelenčić V, et al. Nat Immunol 2018. Among authors: Lenartic M. PMID 30224819 Free PMC article.
Expression of NKG2D before the immature NK cell stage increased expression of the adaptor CD3ζ. Reduced expression of CD3ζ in Klrk1(-/-) mice was associated with enhanced signal transduction through NCR1, and CD3ζ deficiency resulted in hyper-responsiveness to stimulation via NCR1. Thus, an activating receptor developmentally set the activity of another activating receptor on NK cells and determined NK cell reactivity to cellular threats....
Expression of NKG2D before the immature NK cell stage increased expression of the adaptor CD3ζ. Reduced expression of CD3ζ in …
Natural Killer Cells Degenerate Intact Sensory Afferents following Nerve Injury
Davies AJ, et al. Cell 2019. Among authors: Lee J, Lee KM, Lee JE. PMID 30712871 Free PMC article.
Sensory axons degenerate following separation from their cell body, but partial injury to peripheral nerves may leave the integrity of damaged axons preserved. ...This neuro-immune mechanism of selective NK cell-mediated degeneration of damaged but intact sensory axons complements Wallerian degeneration and suggests the therapeutic potential of modulating NK cell function to resolve painful neuropathy through the clearance of partially damaged nerves....
Sensory axons degenerate following separation from their cell body, but partial injury to peripheral nerves may leave the inte …
NKG2D and Its Ligands: "One for All, All for One"
Zingoni A, et al. Front Immunol 2018 - Review. PMID 29662484 Free PMC article.
These ligands are poorly expressed on normal cells but can be induced on damaged, transformed or infected cells, with the final NKG2D ligand expression resulting from multiple levels of regulation. ...A large body of evidence demonstrates that NK cell activation can be triggered by different NKG2D ligands, often expressed on the same cell, suggesting a functional redundancy of these molecules. ...
These ligands are poorly expressed on normal cells but can be induced on damaged, transformed or infected cells, with the final NKG2D ligand …
Antibody-mediated inhibition of MICA and MICB shedding promotes NK cell-driven tumor immunity.
Ferrari de Andrade L, et al. Science 2018. PMID 29599246 Free PMC article.
We rationally designed antibodies targeting the MICA α3 domain, the site of proteolytic shedding, and found that these antibodies prevented loss of cell surface MICA and MICB by human cancer cells. ...Antitumor immunity was mediated mainly by natural killer (NK) cells through activation of NKG2D and CD16 Fc receptors. This approach prevents the loss of important immunostimulatory ligands by human cancers and reactivates antitumor immunity....
We rationally designed antibodies targeting the MICA α3 domain, the site of proteolytic shedding, and found that these antibodies prevented …
Regulation of NKG2D-Dependent NK Cell Functions: The Yin and the Yang of Receptor Endocytosis.
Molfetta R, et al. Int J Mol Sci 2017 - Review. PMID 28767057 Free PMC article.
Although NKG2D ligands represent danger signals that render target cells more susceptible to NK cell lysis, accumulating evidence demonstrates that persistent exposure to ligand-expressing cells causes the decrease of NKG2D surface expression leading to a functional impairment of NKG2D-dependent NK cell functions. ...However, receptor endocytosis is not only a mechanism of receptor clearance from the cell surface, but is also required for the proper activation of signalling events leading to the functional program of NK cells. ...
Although NKG2D ligands represent danger signals that render target cells more susceptible to NK cell lysis, accumulating evide …
Mechanisms of NK Cell Activation and Clinical Activity of the Therapeutic SLAMF7 Antibody, Elotuzumab in Multiple Myeloma.
Campbell KS, et al. Front Immunol 2018 - Review. PMID 30455698 Free PMC article.
Multiple myeloma (MM) is a bone marrow plasma cell neoplasm and is the second most-common hematologic malignancy. Despite advances in therapy, MM remains largely incurable. ...In RRMM patients, elotuzumab monotherapy did not produce objective responses, but did enhance the activity of approved standard of care therapies, including lenalidomide or bortezomib, which are known to enhance anti-tumor responses by NK cells. ...
Multiple myeloma (MM) is a bone marrow plasma cell neoplasm and is the second most-common hematologic malignancy. Despite advances in …
NK cell heparanase controls tumor invasion and immune surveillance.
Putz EM, et al. J Clin Invest 2017. PMID 28581441 Free PMC article.
NK cells are highly efficient at preventing cancer metastasis but are infrequently found in the core of primary tumors. Here, have we demonstrated that freshly isolated mouse and human NK cells express low levels of the endo-β-D-glucuronidase heparanase that increase upon NK cell activation. ...NK cell invasion of primary tumors and recruitment to the site of metastasis were strictly dependent on the presence of heparanase. ...
NK cells are highly efficient at preventing cancer metastasis but are infrequently found in the core of primary tumors. Here, have we
NKG2D and its ligands in cancer
Dhar P and Wu JD. Curr Opin Immunol 2018 - Review. PMID 29525346 Free PMC article.
NKG2D is an activating immune receptor expressed by NK and effector T cells. Induced expression of NKG2D ligand on tumor cell surface during oncogenic insults renders cancer cells susceptible to immune destruction. ...
NKG2D is an activating immune receptor expressed by NK and effector T cells. Induced expression of NKG2D ligand on tumor cell
Natural killer group 2D receptor and its ligands in cancer immune escape
Duan S, et al. Mol Cancer 2019 - Review. PMID 30813924 Free PMC article.
In this review, we describe the mechanisms of natural killer group 2D (NKG2D) receptor and NKG2D ligand (NKG2DL) in tumor immune responses.Natural killer (NK) cells are important cytotoxic cells in the immune system, and the activated NKG2D receptor on the NK cell surface can bind to NKG2DL expressed in tumor cells, enabling NK cells to activate and kill tumor cells. ...Tumor cells regulate the expression of NKG2DL at the level of transcription, translation, and post-translation and thereby escape recognition by NK cells. ...
In this review, we describe the mechanisms of natural killer group 2D (NKG2D) receptor and NKG2D ligand (NKG2DL) in tumor immune responses.N …
Alopecia areata: a review of disease pathogenesis
Rajabi F, et al. Br J Dermatol 2018 - Review. PMID 29791718
The psychological impact can be significant, leading to feelings of depression and social isolation. Objectives In this article, we seek to review the pathophysiological mechanisms proposed in recent years in a narrative fashion. ...Different immune-cell lines including plasmacytoid dendritic cells, natural killer cells and T cells, along with key molecules such as interferon-γ, interleukin-15, MICA and NKG2D, have been identified as contributing to the autoimmune process. ...
The psychological impact can be significant, leading to feelings of depression and social isolation. Objectives In this article, we s …
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