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1999 1
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Page 1
SAR analysis of novel non-peptidic NPBWR1 (GPR7) antagonists.
Guerrero M, Urbano M, Schaeffer MT, Brown S, Rosen H, Roberts E. Guerrero M, et al. Bioorg Med Chem Lett. 2013 Feb 1;23(3):614-9. doi: 10.1016/j.bmcl.2012.12.030. Epub 2012 Dec 20. Bioorg Med Chem Lett. 2013. PMID: 23287738 Free PMC article.
The discovery of potent antagonists of NPBWR1 (GPR7).
Anthony Romero F, Hastings NB, Moningka R, Guo Z, Wang M, Di Salvo J, Lei Y, Trusca D, Deng Q, Tong V, Terebetski JL, Ball RG, Ujjainwalla F. Anthony Romero F, et al. Bioorg Med Chem Lett. 2012 Jan 15;22(2):1014-8. doi: 10.1016/j.bmcl.2011.11.126. Epub 2011 Dec 8. Bioorg Med Chem Lett. 2012. PMID: 22197390
G protein receptors 7 and 8 are expressed in human adrenocortical cells, and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascades.
Mazzocchi G, Rebuffat P, Ziolkowska A, Rossi GP, Malendowicz LK, Nussdorfer GG. Mazzocchi G, et al. J Clin Endocrinol Metab. 2005 Jun;90(6):3466-71. doi: 10.1210/jc.2004-2132. Epub 2005 Mar 29. J Clin Endocrinol Metab. 2005. PMID: 15797961
Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8.
Tanaka H, Yoshida T, Miyamoto N, Motoike T, Kurosu H, Shibata K, Yamanaka A, Williams SC, Richardson JA, Tsujino N, Garry MG, Lerner MR, King DS, O'Dowd BF, Sakurai T, Yanagisawa M. Tanaka H, et al. Proc Natl Acad Sci U S A. 2003 May 13;100(10):6251-6. doi: 10.1073/pnas.0837789100. Epub 2003 Apr 28. Proc Natl Acad Sci U S A. 2003. PMID: 12719537 Free PMC article.
19 results