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2001 1
2003 3
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2015 3
2016 3
2019 2
2020 0
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Page 1
An improved smaller biotin ligase for BioID proximity labeling.
Kim DI, et al. Mol Biol Cell 2016. PMID 26912792 Free PMC article.
The BioID method uses a promiscuous biotin ligase to detect protein-protein associations as well as proximate proteins in living cells. Here we report improvements to the BioID method centered on BioID2, a substantially smaller promiscuous biotin ligase. BioID2 enables more-selective targeting of fusion proteins, requires less biotin supplementation, and exhibits enhanced labeling of proximate proteins. ...
The BioID method uses a promiscuous biotin ligase to detect protein-protein associations as well as proximate
Mutations in NUP160 Are Implicated in Steroid-Resistant Nephrotic Syndrome.
Zhao F, et al. J Am Soc Nephrol 2019. PMID 30910934 Free PMC article.
The NUP160 gene, which encodes one of the protein components of the nuclear pore complex nucleoporin 160 kD (Nup160), is expressed in both human and mouse kidney cells. Knockdown of NUP160 impairs mouse podocytes in cell culture. Recently, siblings with SRNS and proteinuria in a nonconsanguineous family were found to carry compound-heterozygous mutations in NUP160. ...
The NUP160 gene, which encodes one of the protein components of the nuclear pore complex nucleoporin 160 kD (Nup160), i …
NUP160-SLC43A3 is a novel recurrent fusion oncogene in angiosarcoma.
Shimozono N, et al. Cancer Res 2015. PMID 26527604 Free article.
Stable expression of the fusion gene in nontransformed human dermal microvascular endothelial cells elicited a gene-expression pattern mimicking ISO-HAS cells and increased cell proliferation, an effect traced in part to NUP160 truncation. Conversely, RNAi-mediated attenuation of NUP160 in ISO-HAS cells decreased cell number. Confirming the oncogenic effects of the fusion protein, subcutaneous implantation of NUP160-SLC43A3-expressing fibroblasts induced tumors resembling human angiosarcoma. ...
Stable expression of the fusion gene in nontransformed human dermal microvascular endothelial cells elicited a gene-expression pattern mimic …
Novel vertebrate nucleoporins Nup133 and Nup160 play a role in mRNA export.
Vasu S, et al. J Cell Biol 2001. PMID 11684705 Free PMC article.
The genes encoding the novel proteins were cloned, and antibodies were produced. Immunofluorescence reveals them to be new nucleoporins, designated Nup160 and Nup133, which are accessible on the basket side of the pore. ...With transfection and in vivo transport assays, we find that specific Nup160 and Nup133 fragments block poly[A]+ RNA export, but not protein import or export. ...
The genes encoding the novel proteins were cloned, and antibodies were produced. Immunofluorescence reveals them to be new nuc …
Heart failure induces significant changes in nuclear pore complex of human cardiomyocytes
Tarazón E, et al. PLoS One 2012. PMID 23152829 Free PMC article.
When we compared protein levels according to etiology, ICM showed significant higher levels of NDC1 (65%, p<0.0001), Nup160 (88%, p<0.0001) and Nup153 (137%, p = 0.004) than those of the CNT levels. ...CONCLUSIONS: This study shows alterations in specific proteins (NDC1, Nup160, Nup153 and Nup93) that compose NPC in ischaemic and dilated human heart. ...
When we compared protein levels according to etiology, ICM showed significant higher levels of NDC1 (65%, p<0.0001), Nup160
Pom121 links two essential subcomplexes of the nuclear pore complex core to the membrane
Mitchell JM, et al. J Cell Biol 2010. PMID 20974814 Free PMC article.
We show that key players mediating these interactions in mammalian cells are the nucleoporins Nup155 and Nup160. Nup155 depletion massively alters NE structure, causing a dramatic decrease in NPC numbers and the improper targeting of membrane proteins to the inner nuclear membrane. ...Furthermore, we demonstrate that the N terminus of Pom121 directly binds the β-propeller regions of Nup155 and Nup160. We propose a model in which the interactions of Pom121 with Nup155 and Nup160 are predicted to assist in the formation of the nuclear pore and the anchoring of the NPC to the pore membrane....
We show that key players mediating these interactions in mammalian cells are the nucleoporins Nup155 and Nup160. Nup155 depletion mas …
Efficient NES-dependent protein nuclear export requires ongoing synthesis and export of mRNAs.
O'Hagan HM and Ljungman M. Exp Cell Res 2004. PMID 15212955
The mechanisms regulating nuclear export of proteins are not fully understood. To investigate whether the efficiency of protein nuclear export may depend on ongoing RNA synthesis and/or mRNA nuclear export, we used a microinjection approach with a fluorescent reporter protein containing a nuclear export signal (NES) and scored protein export in human fibroblasts under conditions when the synthesis or export of mRNAs was inhibited. ...Finally, nuclear export of the NES reporter protein was significantly inhibited in cells in which nuclear export of mRNAs had been specifically blocked by microinjection of anti-TAP antibodies or by expression of a dominant negative form of NUP160. ...
The mechanisms regulating nuclear export of proteins are not fully understood. To investigate whether the efficiency of protein
RCC2, a regulator of the RalA signaling pathway, is identified as a novel therapeutic target in cisplatin-resistant ovarian cancer
Gong S, et al. FASEB J 2019. PMID 30768358
RCC2 plays a positive role in cell proliferation, apoptosis, and migration in DDP-resistant ovarian cancer cell lines in vitro and in vivo. Furthermore, RCC2 could interact with RalA, thus promoting its downstream effector RalBP1. RalA knockdown could reverse the effects of RCC2 overexpression on DDP-resistant ovarian cancer cell proliferation, apoptosis, and migration. ...
RCC2 plays a positive role in cell proliferation, apoptosis, and migration in DDP-resistant ovarian cancer cell lines in vitro and in …
Evolution of a transcriptional regulator from a transmembrane nucleoporin
Franks TM, et al. Genes Dev 2016. PMID 27198230 Free PMC article.
While the primary role of NPCs is to regulate nucleo-cytoplasmic transport, recent research suggests that certain NPC proteins have additionally acquired the role of affecting gene expression at the nuclear periphery and in the nucleoplasm in metazoans. ...Instead, sPom121 colocalizes and interacts with nucleoplasmic Nup98, a previously identified transcriptional regulator, at gene promoters to control transcription of its target genes in human cells. ...
While the primary role of NPCs is to regulate nucleo-cytoplasmic transport, recent research suggests that certain NPC proteins have a …
Intranuclear dynamics of the Nup107-160 complex
Morchoisne-Bolhy S, et al. Mol Biol Cell 2015. PMID 25904327 Free PMC article.
During cell division, Y-Nup-containing GLFG bodies are disassembled in mitotic prophase, significantly ahead of nuclear pore disassembly. ...
During cell division, Y-Nup-containing GLFG bodies are disassembled in mitotic prophase, significantly ahead of nuclear pore disassem …
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