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151 results

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Page 1
Saline nasal irrigation for acute upper respiratory tract infections.
King D, Mitchell B, Williams CP, Spurling GK. King D, et al. Cochrane Database Syst Rev. 2015 Apr 20;2015(4):CD006821. doi: 10.1002/14651858.CD006821.pub3. Cochrane Database Syst Rev. 2015. PMID: 25892369 Free PMC article.
The trial also showed a significant reduction in the use of decongestant medication by the saline group. Minor nasal discomfort and/or irritation was the only side effect reported by a minority of participants. ...
The trial also showed a significant reduction in the use of decongestant medication by the saline group. Minor nasal discomfort …
Safety, tolerability, and efficacy of zavegepant 10 mg nasal spray for the acute treatment of migraine in the USA: a phase 3, double-blind, randomised, placebo-controlled multicentre trial.
Lipton RB, Croop R, Stock DA, Madonia J, Forshaw M, Lovegren M, Mosher L, Coric V, Goadsby PJ. Lipton RB, et al. Lancet Neurol. 2023 Mar;22(3):209-217. doi: 10.1016/S1474-4422(22)00517-8. Lancet Neurol. 2023. PMID: 36804093 Clinical Trial.
The most common adverse events in either treatment group (2%) were dysgeusia (129 [21%] of 629 in the zavegepant group vs 31 [5%] of 653 in the placebo group), nasal discomfort (23 [4%] vs five [1%]), and nausea (20 [3%] vs seven [1%]). No signal of hepatotoxicity d …
The most common adverse events in either treatment group (2%) were dysgeusia (129 [21%] of 629 in the zavegepant group vs 31 [5%] of 653 in …
Zavegepant nasal spray for the acute treatment of migraine: A Phase 2/3 double-blind, randomized, placebo-controlled, dose-ranging trial.
Croop R, Madonia J, Stock DA, Thiry A, Forshaw M, Murphy A, Coric V, Lipton RB. Croop R, et al. Headache. 2022 Oct;62(9):1153-1163. doi: 10.1111/head.14389. Epub 2022 Oct 14. Headache. 2022. PMID: 36239038 Free PMC article. Clinical Trial.
The most common treatment-emergent adverse events with zavegepant 10 and 20 mg and placebo were dysgeusia (13.5% to 16.1% vs. 3.5%), nausea (2.7% to 4.1% vs. 0.5%), and nasal discomfort (1.3% to 5.2% vs. 0.2%). Most adverse events were mild or moderate and resolved …
The most common treatment-emergent adverse events with zavegepant 10 and 20 mg and placebo were dysgeusia (13.5% to 16.1% vs. 3.5%), nausea …
New Nasal Spray for Migraine Headaches.
Aschenbrenner DS. Aschenbrenner DS. Am J Nurs. 2023 Jul 1;123(7):16. doi: 10.1097/01.NAJ.0000944900.69960.ee. Am J Nurs. 2023. PMID: 37345774
It should not be used as a preventative.The most common adverse effects of zavegepant are taste disorders, nausea, nasal discomfort, and vomiting. Hypersensitivity reactions are also possible.Patients should avoid coadministration with intranasal decongestants, as t …
It should not be used as a preventative.The most common adverse effects of zavegepant are taste disorders, nausea, nasal discomfor …
Methodological Principles of Nasal Food Challenge.
Krzych-Fałta E, Czerwińska ME, Białek S, Furmańczyk K, Samoliński B, Grodner B, Sybilski A, Nowicka G, Wojas O. Krzych-Fałta E, et al. Nutrients. 2023 Aug 31;15(17):3816. doi: 10.3390/nu15173816. Nutrients. 2023. PMID: 37686848 Free PMC article.
No significant differences were observed concerning the perceived nasal discomfort using the visual analog scale. Due to the absence of nasal mucosal reactivity, nasal challenge is an excellent methodological tool for implementing food allergen tests....
No significant differences were observed concerning the perceived nasal discomfort using the visual analog scale. Due to the a …
Nasal splints, revisited.
Malki D, Quine SM, Pfleiderer AG. Malki D, et al. J Laryngol Otol. 1999 Aug;113(8):725-7. doi: 10.1017/s0022215100145037. J Laryngol Otol. 1999. PMID: 10748847 Clinical Trial.
However, the patients with splints had significantly more pain and nasal discomfort when assessed one week after surgery. It is concluded that the morbidity associated with nasal splints does not justify their use in routine nasal surgery if the aim is to prevent na …
However, the patients with splints had significantly more pain and nasal discomfort when assessed one week after surgery. It i …
[Application of nasal saline irrigation in nasal inflammatory diseases].
Tan L, Xu Y. Tan L, et al. Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Jan;33(1):90-96. doi: 10.13201/j.issn.1001-1781.2019.01.020. Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019. PMID: 30669208 Review. Chinese.
Positive pressure should be an optimized method of SI. The side effects of SI include nasal discomfort, otalgia, and pooling of saline in sinuses with subsequent drainage. ...
Positive pressure should be an optimized method of SI. The side effects of SI include nasal discomfort, otalgia, and pooling o …
[Nasal obstruction].
Vincent Y. Vincent Y. Rev Med Brux. 1997 Sep;18(4):144-8. Rev Med Brux. 1997. PMID: 9411633 Review. French.
Nasal obstruction can also be caused by anomalies in the structure of the nasal passages or paranasal cavities, or by anomalies in the mucosa in the nasal passages, or by tumours. Subjective nasal obstruction or nasal discomfort is a pathology at the limit of the co …
Nasal obstruction can also be caused by anomalies in the structure of the nasal passages or paranasal cavities, or by anomalies in the mucos …
Glyphosate poisoning.
Bradberry SM, Proudfoot AT, Vale JA. Bradberry SM, et al. Toxicol Rev. 2004;23(3):159-67. doi: 10.2165/00139709-200423030-00003. Toxicol Rev. 2004. PMID: 15862083 Review.
Inhalation is a minor route of exposure but spray mist may cause oral or nasal discomfort, an unpleasant taste in the mouth, tingling and throat irritation. Eye exposure may lead to mild conjunctivitis, and superficial corneal injury is possible if irrigation is del …
Inhalation is a minor route of exposure but spray mist may cause oral or nasal discomfort, an unpleasant taste in the mouth, t …
Long-term safety of zavegepant nasal spray for the acute treatment of migraine: A phase 2/3 open-label study.
Mullin K, Croop R, Mosher L, Fullerton T, Madonia J, Lipton RB. Mullin K, et al. Cephalalgia. 2024 Aug;44(8):3331024241259456. doi: 10.1177/03331024241259456. Cephalalgia. 2024. PMID: 39210835 Free article. Clinical Trial.
The most common treatment-emergent adverse events (5% of participants) were dysgeusia (39.1% [236/603]); nasal discomfort (10.3% [62/603]); COVID-19 (7.5% [45/603]); nausea (6.1% [37/603]); nasal congestion and throat irritation (5.5% [33/603] each); and back pain ( …
The most common treatment-emergent adverse events (5% of participants) were dysgeusia (39.1% [236/603]); nasal discomfort (10. …
151 results