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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2001 24
2002 99
2003 84
2004 84
2005 83
2006 85
2007 81
2008 96
2009 84
2010 141
2011 181
2012 176
2013 160
2014 156
2015 131
2016 150
2017 133
2018 127
2019 144
2020 25
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2,170 results
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Page 1
The biology and function of fibroblasts in cancer.
Kalluri R. Nat Rev Cancer 2016 - Review. PMID 27550820
Cancer is associated with fibroblasts at all stages of disease progression, including metastasis, and they are a considerable component of the general host response to tissue damage caused by cancer cells. ...The pleiotropic actions of CAFs on tumour cells are probably reflective of them being a heterogeneous and plastic population with context-dependent influence on cancer....
Cancer is associated with fibroblasts at all stages of disease progression, including metastasis, and they are a considerable compone
Organoids in cancer research.
Drost J and Clevers H. Nat Rev Cancer 2018 - Review. PMID 29692415
Such preclinical models are essential for more efficient translation of basic cancer research into novel treatment regimens for patients with cancer. ...In this Review, we evaluate tumour organoid protocols and how they can be utilized as an alternative model for cancer research....
Such preclinical models are essential for more efficient translation of basic cancer research into novel treatment regimens for patie …
Targeting autophagy in cancer.
Levy JMM, et al. Nat Rev Cancer 2017 - Review. PMID 28751651 Free PMC article.
Autophagy has opposing, context-dependent roles in cancer, and interventions to both stimulate and inhibit autophagy have been proposed as cancer therapies. This has led to the therapeutic targeting of autophagy in cancer to be sometimes viewed as controversial. In this Review, we suggest a way forwards for the effective targeting of autophagy by understanding the context-dependent roles of autophagy and by capitalizing on modern approaches to clinical trial design....
Autophagy has opposing, context-dependent roles in cancer, and interventions to both stimulate and inhibit autophagy have been propos …
Cancer nanomedicine: progress, challenges and opportunities.
Shi J, et al. Nat Rev Cancer 2017 - Review. PMID 27834398 Free PMC article.
The intrinsic limits of conventional cancer therapies prompted the development and application of various nanotechnologies for more effective and safer cancer treatment, herein referred to as cancer nanomedicine. ...This Review highlights the progress, challenges and opportunities in cancer nanomedicine and discusses novel engineering approaches that capitalize on our growing understanding of tumour biology and nano-bio interactions to develop more effective nanotherapeutics for cancer patients....
The intrinsic limits of conventional cancer therapies prompted the development and application of various nanotechnologies for more e …
Artificial intelligence in radiology
Hosny A, et al. Nat Rev Cancer 2018 - Review. PMID 29777175 Free PMC article.
Fasting and cancer: molecular mechanisms and clinical application.
Nencioni A, et al. Nat Rev Cancer 2018 - Review. PMID 30327499 Free PMC article.
The vulnerability of cancer cells to nutrient deprivation and their dependency on specific metabolites are emerging hallmarks of cancer. Fasting or fasting-mimicking diets (FMDs) lead to wide alterations in growth factors and in metabolite levels, generating environments that can reduce the capability of cancer cells to adapt and survive and thus improving the effects of cancer therapies. ...
The vulnerability of cancer cells to nutrient deprivation and their dependency on specific metabolites are emerging hallmarks of c
Pre-metastatic niches: organ-specific homes for metastases
Peinado H, et al. Nat Rev Cancer 2017 - Review. PMID 28303905 Free article.
Sowing the 'seeds' of metastasis requires the action of tumour-secreted factors and tumour-shed extracellular vesicles that enable the 'soil' at distant metastatic sites to encourage the outgrowth of incoming cancer cells. ...
Sowing the 'seeds' of metastasis requires the action of tumour-secreted factors and tumour-shed extracellular vesicles that enable the 'soil …
Sphingolipid metabolism in cancer signalling and therapy.
Ogretmen B. Nat Rev Cancer 2018 - Review. PMID 29147025 Free PMC article.
This Review summarizes how ceramide-induced cellular stress mediates cancer cell death through various mechanisms involving the induction of apoptosis, necroptosis and/or mitophagy. ...Finally, studies targeting enzymes involved in sphingolipid metabolism and/or signalling and their clinical implications for improving cancer therapeutics are also presented....
This Review summarizes how ceramide-induced cellular stress mediates cancer cell death through various mechanisms involving the induc …
Every step of the way: integrins in cancer progression and metastasis.
Hamidi H and Ivaska J. Nat Rev Cancer 2018 - Review. PMID 30002479 Free PMC article.
Integrin-mediated sensing, stiffening and remodelling of the tumour stroma are key steps in cancer progression supporting invasion, acquisition of cancer stem cell characteristics and drug resistance. Given the complexity of integrins and their adaptable and sometimes antagonistic roles in cancer cells and the tumour microenvironment, therapeutic targeting of these receptors has been a challenge. ...
Integrin-mediated sensing, stiffening and remodelling of the tumour stroma are key steps in cancer progression supporting invasion, a …
Targeting metastasis
Steeg PS. Nat Rev Cancer 2016 - Review. PMID 27009393
Tumour metastasis, the movement of tumour cells from a primary site to progressively colonize distant organs, is a major contributor to the deaths of cancer patients. ...
Tumour metastasis, the movement of tumour cells from a primary site to progressively colonize distant organs, is a major contributor to the …
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