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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1965 2
1966 9
1967 9
1968 1
1973 1
1976 2
1977 1
1986 2
1987 1
1988 1
1989 26
1990 121
1991 121
1992 125
1993 134
1994 155
1995 166
1996 151
1997 144
1998 168
1999 169
2000 230
2001 248
2002 248
2003 270
2004 307
2005 298
2006 259
2007 308
2008 310
2009 354
2010 338
2011 378
2012 361
2013 316
2014 307
2015 274
2016 250
2017 286
2018 278
2019 78
2020 1
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6,610 results
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Nerve Dependence: From Regeneration to Cancer.
Boilly B, et al. Cancer Cell 2017 - Review. PMID 28292437 Free article.
Nerve dependence has long been described in animal regeneration, where the outgrowth of axons is necessary to the reconstitution of lost body parts and tissue remodeling in various species. Recent discoveries have demonstrated that denervation can suppress tumor growth and metastasis, pointing to nerve dependence in cancer. ...
Nerve dependence has long been described in animal regeneration, where the outgrowth of axons is necessary to the reconstituti
The multicellular complexity of peripheral nerve regeneration.
Cattin AL and Lloyd AC. Curr Opin Neurobiol 2016 - Review. PMID 27128880
Peripheral nerves show a remarkable ability to regenerate following a transection injury. Downstream of the cut, the axons degenerate and so to regenerate the nerve, the severed axons need to regrow back to their targets and regain function. This requires the axons to navigate through two different environments. (1) The bridge of new tissue that forms between the two nerve stumps and (2) the distal stump of the nerve that remains associated with the target tissues. ...
Peripheral nerves show a remarkable ability to regenerate following a transection injury. Downstream of the cut, the axons degenerate …
Optimal electrical stimulation boosts stem cell therapy in nerve regeneration.
Du J, et al. Biomaterials 2018. PMID 30098570 Free PMC article.
Stem cell therapy holds significant promise for peripheral nerve regeneration, but maintenance of stem cell viability and differentiation potential in vivo are still major obstacles for translation. ...Overall, ES on NCSC transplantation significantly enhanced nerve regeneration after injury and repair, and was comparable to autograft treatment. ...
Stem cell therapy holds significant promise for peripheral nerve regeneration, but maintenance of stem cell viability and diff …
Regeneration of peripheral nerves by nerve guidance conduits: Influence of design, biopolymers, cells, growth factors, and physical stimuli.
Sarker MD, et al. Prog Neurobiol 2018 - Review. PMID 30077776
In this regard, implanted artificial nerve guidance conduits (NGCs) used to bridge an injured site may provide appropriate biochemical and biophysical guidance cues required to stimulate regeneration across a nerve gap and restore the function of PNS. ...This paper briefly reviews the recent progress in the development of these NGCs for nerve regeneration, focusing on the design and fabrication of NGCs, as well as the influence of biopolymers, cells, growth factors, and physical stimuli. ...
In this regard, implanted artificial nerve guidance conduits (NGCs) used to bridge an injured site may provide appropriate biochemica …
Dissecting spinal cord regeneration.
Sofroniew MV. Nature 2018 - Review. PMID 29769671
The inability to recover functions lost after severe spinal cord injury has been recognized for millennia and was first attributed to a failure of spinal cord neural regeneration over 100 years ago. ...I argue that expanding mechanistic knowledge about multiple forms of neural regeneration, why they fail and how they can restore function will resolve conceptual contentions and push the field forward....
The inability to recover functions lost after severe spinal cord injury has been recognized for millennia and was first attributed to a fail …
Biologic strategies to improve nerve regeneration after peripheral nerve repair.
Fowler JR, et al. J Reconstr Microsurg 2015 - Review. PMID 25503421
However, the use of nerve autograft has associated donor site morbidity and limited availability. METHODS: A review of the literature was performed to determine current biologic strategies to improve nerve regeneration after nerve repair. ...CONCLUSIONS: Sensory and motor recovery after peripheral nerve regeneration remains suboptimal, especially in cases where primary nerve repair is not possible. ...
However, the use of nerve autograft has associated donor site morbidity and limited availability. METHODS: A review of the literature …
Increasing Nerve Autograft Length Increases Senescence and Reduces Regeneration.
Hoben GM, et al. Plast Reconstr Surg 2018. PMID 29994844 Free PMC article.
BACKGROUND: Nerve grafting with an autograft is considered the gold standard. However, the functional outcomes of long (>3 cm) nerve autografting are often poor. ...METHODS: A rat sciatic nerve defect model was used to compare regeneration in short (2 cm) and long (6 cm) isografts. Axon regeneration and cell populations within grafts were assessed using histology, retrograde labeling of neurons regenerating axons, immunohistochemistry, quantitative reverse transcriptase polymerase chain reaction, and electron microscopy at 4 and/or 8 weeks. ...
BACKGROUND: Nerve grafting with an autograft is considered the gold standard. However, the functional outcomes of long (>3 cm) …
The repair Schwann cell and its function in regenerating nerves.
Jessen KR and Mirsky R. J Physiol 2016 - Review. PMID 26864683 Free PMC article.
Nerve injury triggers the conversion of myelin and non-myelin (Remak) Schwann cells to a cell phenotype specialized to promote repair. Distal to damage, these repair Schwann cells provide the necessary signals and spatial cues for the survival of injured neurons, axonal regeneration and target reinnervation. ...
Nerve injury triggers the conversion of myelin and non-myelin (Remak) Schwann cells to a cell phenotype specialized to promote repair
Schwann Cells: Development and Role in Nerve Repair.
Jessen KR, et al. Cold Spring Harb Perspect Biol 2015 - Review. PMID 25957303 Free PMC article.
We also discuss the phenotypic plasticity retained by mature Schwann cells, and explain why this unusual feature is central to the striking regenerative potential of the peripheral nervous system (PNS)....
We also discuss the phenotypic plasticity retained by mature Schwann cells, and explain why this unusual feature is central to the striking …
Stem cell-based approaches to enhance nerve regeneration and improve functional outcomes in vascularized composite allotransplantation.
Tung TH and Mackinnon SE. Curr Opin Organ Transplant 2018 - Review. PMID 30138147
PURPOSE OF REVIEW: The current review will discuss the current understanding of nerve regeneration in vascularized composite allotransplantation (VCA). ...RECENT FINDINGS: The effect of rejection on nerve regeneration in the VCA may be unpredictable and may be quite different for the nerve allograft. ...
PURPOSE OF REVIEW: The current review will discuss the current understanding of nerve regeneration in vascularized composite a …
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