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Year Number of Results
1990 1
1991 2
1992 4
1993 3
1994 5
1995 9
1996 6
1997 13
1998 12
1999 20
2000 18
2001 31
2002 30
2003 34
2004 66
2005 73
2006 77
2007 56
2008 58
2009 77
2010 62
2011 48
2012 43
2013 36
2014 16
2015 9
2016 9
2017 8
2018 4
2019 3
2020 0
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765 results
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Page 1
Antipsychotics promote GABAergic interneuron genesis in the adult rat brain: Role of heat-shock protein production.
Kaneta H, et al. J Psychiatr Res 2017. PMID 28414930
We also demonstrated that antipsychotics restored heat-shock protein (HSP) production in NG2(+) cells with differentiation impairment. ...Our results showed that antipsychotics, particularly those recently synthesized, exerted similar GABAergic interneuron genesis effects on NG2(+) neuronal/glial progenitor cells in the adult rat brain by increasing cellular HSP production, and also suggest that HSP90 may play a crucial role in the pathophysiology of schizophrenia and is a key target for next drug development....
We also demonstrated that antipsychotics restored heat-shock protein (HSP) production in NG2(+) cells with differentiation impairment …
Shikonin‑mediated inhibition of nestin affects hypoxia‑induced proliferation of pulmonary artery smooth muscle cells
He S, et al. Mol Med Rep 2018. PMID 30066896
The present study was designed to investigate the effects of shikonin on the proliferation of rat PASMCs and the possible mechanisms involved. ...The viability of PASMCs was measured using the Cell Counting Kit‑8 assay, the mRNA expression of nestin (NES) in each group was measured by reverse transcription‑polymerase chain reaction and the protein expression of NES was measured by western blotting. ...
The present study was designed to investigate the effects of shikonin on the proliferation of rat PASMCs and the possible mechanisms …
Reversal effects of low-dose imatinib compared with sunitinib on monocrotaline-induced pulmonary and right ventricular remodeling in rats
Leong ZP, et al. Vascul Pharmacol 2018. PMID 29100963
Sunitinib also suppressed VEGF-A, but not phosphorylated extra-cellular-signal-related kinase (ERK)-1/2 protein expression. The sole PDGFR-β antagonism of imatinib resulted in significant Raf-1 mRNA and phosphorylated ERK-1/2 protein downregulation, suggesting that the equivocal reversal effect of sunitinib may be due to its VEGF signaling inhibition in the lung. ...
Sunitinib also suppressed VEGF-A, but not phosphorylated extra-cellular-signal-related kinase (ERK)-1/2 protein expression. The sole …
Nestin-Cre transgenic mouse line Nes-Cre1 mediates highly efficient Cre/loxP mediated recombination in the nervous system, kidney, and somite-derived tissues.
Dubois NC, et al. Genesis 2006. PMID 16847871
Here we describe the generation of the Nes-Cre1 transgenic mouse line in which Cre recombinase expression is controlled by the rat nestin promoter and intron 2 enhancer. ...This study suggests that Nes-Cre1-mediated recombination occurs in progenitor cell types present in the neuroectoderm, the developing mesonephros, and the somites....
Here we describe the generation of the Nes-Cre1 transgenic mouse line in which Cre recombinase expression is controlled by the rat
Distribution of nestin protein: immunohistochemical study in enteric plexus of rat duodenum.
Cantarero Carmona I, et al. Microsc Res Tech 2011. PMID 21275002
We examined by immunohistochemistry the appearance and distribution of nestin protein in enteric ganglia of rat duodenum. Through the myenteric and submucosal plexuses, a high number of nestin-positive cells were visualized in this specie. ...The results of this study suggest that the rat enteric glial cells (EGCs) are rich in nestin, a protein usually associated with dividing or migrating cells and the dynamic reorganization of nestin filaments during the cell cycle. ...
We examined by immunohistochemistry the appearance and distribution of nestin protein in enteric ganglia of rat duodenum. Thro …
Endothelial cells are a source of Nestin expression in Pulmonary Arterial Hypertension
Bhagwani AR, et al. PLoS One 2019. PMID 30883593 Free PMC article.
Both proliferation and cytoskeleton reorganization are associated with upregulation of the intermediate filament protein Nestin. ...In vitro, both growing rat and human lung endothelial cells expressed Nestin protein. When Nestin was overexpressed in endothelial cells (both rat and human), Nestin overexpression promoted proliferation and expression of CXC chemokine ligand 12. ...
Both proliferation and cytoskeleton reorganization are associated with upregulation of the intermediate filament protein Nestin. ...I …
Glial fibrillary acidic protein is expressed in the aged rat olfactory epithelium.
Kim MK, et al. Acta Otolaryngol 2005. PMID 16158537
CONCLUSION: Our findings suggest that the aging process induces changes in the phenotype of olfactory supporting cells in the rat. OBJECTIVE: To investigate age-related changes in the expression of astroglial intermediate filament proteins in the olfactory supporting cells of the rat. ...
CONCLUSION: Our findings suggest that the aging process induces changes in the phenotype of olfactory supporting cells in the rat. OB …
Developmentally regulated expression of the cold-inducible RNA-binding motif protein 3 in euthermic rat brain.
Pilotte J, et al. Brain Res 2009. PMID 19150436
mRNA-binding proteins are critical regulators of protein synthesis during neural development. We demonstrated previously that the cold-inducible mRNA-binding protein 3 (RBM3) is present within euthermic neurons and that it enhances translation. ...Here we characterize the developmental expression of RBM3 in rat brain. RBM3 is expressed widely during early brain development, peaking in the first to second postnatal weeks. ...
mRNA-binding proteins are critical regulators of protein synthesis during neural development. We demonstrated previously that the col …
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