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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1990 1
1991 2
1992 6
1993 3
1994 10
1995 14
1996 15
1997 28
1998 18
1999 35
2000 44
2001 66
2002 64
2003 89
2004 132
2005 175
2006 204
2007 183
2008 209
2009 217
2010 196
2011 219
2012 204
2013 254
2014 215
2015 170
2016 161
2017 157
2018 107
2019 42
2020 0
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2,904 results
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Page 1
Nestin-expressing progenitor cells: function, identity and therapeutic implications.
Bernal A and Arranz L. Cell Mol Life Sci 2018 - Review. PMID 29541793 Free PMC article.
The neuroepithelial stem cell protein, or Nestin, is a cytoskeletal intermediate filament initially characterized in neural stem cells. ...Future improved in vivo models and detection methods will allow to determine the true essence of Nestin(+) cells and confirm their potential application as therapeutic target in a range of diseases....
The neuroepithelial stem cell protein, or Nestin, is a cytoskeletal intermediate filament initially characterized in neural stem cell …
Nuclear Nestin deficiency drives tumor senescence via lamin A/C-dependent nuclear deformation.
Zhang Y, et al. Nat Commun 2018. PMID 30190500 Free PMC article.
However, the mechanistic contributions of Nestin to cancer pathogenesis are still unknown. In the present study, previously thought to reside exclusively in the cytoplasm, Nestin can also be found in the nucleus and participate in protecting tumor cells against cellular senescence. Specifically, we reveal that Nestin has a nuclear localization signal (aa318-aa347) at the downstream of rod domain. We then find nuclear Nestin could interact with lamin A/C. ...
However, the mechanistic contributions of Nestin to cancer pathogenesis are still unknown. In the present study, previously thought t …
Nestin as a marker of cancer stem cells.
Neradil J and Veselska R. Cancer Sci 2015 - Review. PMID 25940879 Free PMC article.
Specifically, nestin has been shown to be expressed in transformed cells of various human malignancies, and a correlation between its expression and the clinical course of some diseases has been proved. Furthermore, the coexpression of nestin with other stem cell markers was described as a CSC phenotype that was subsequently verified using tumorigenicity assays. ...
Specifically, nestin has been shown to be expressed in transformed cells of various human malignancies, and a correlation between its …
Nestin expression is dynamically regulated in cardiomyocytes during embryogenesis.
Hertig V, et al. J Cell Physiol 2018. PMID 28834610 Free PMC article.
The transcriptional factors implicated in the expression of the intermediate filament protein nestin in cardiomyocytes during embryogenesis remain undefined. ...These findings demonstrate that Tbx5- and Gata4-dependent events negatively regulate nestin expression in cardiomyocytes during embryogenesis. ...
The transcriptional factors implicated in the expression of the intermediate filament protein nestin in cardiomyocytes during embryog …
Role of nestin expression in angiogenesis and breast cancer progression.
Nowak A, et al. Int J Oncol 2018. PMID 29345290
Nestin is an intermediate filament protein and a stem cell marker expressed in several tumours. There is growing evidence of an association between the expression level of nestin and the pathogenesis of triple-negative breast cancer (TNBC). ...Our results demonstrated that nestin expression in tumour cells correlated with the area and number of vessels expressing nestin, CD31, CD34 and SOX-18. ...
Nestin is an intermediate filament protein and a stem cell marker expressed in several tumours. There is growing evidence of an assoc
Nestin expression is differently regulated between odontoblasts and the subodontoblastic layer in mice.
Nakatomi M, et al. Histochem Cell Biol 2018. PMID 29445893
Although Nestin has also been used as a differentiation marker for odontoblasts during tooth development, how Nestin expression is regulated in odontoblasts remains unclear. Therefore, this study aimed to compare the expression patterns of Nestin-GFP (green fluorescent protein) with that of endogenous Nestin in developing teeth of Nestin-EGFP (enhanced GFP) transgenic mice, in which the second intron enhancer is connected with the EGFP domain, at postnatal 7d, 3w, and 8w. ...
Although Nestin has also been used as a differentiation marker for odontoblasts during tooth development, how Nestin expressio …
Implications of nestin in breast cancer pathogenesis (Review).
Nowak A and Dziegiel P. Int J Oncol 2018 - Review. PMID 29901100
The aim of the present review was to summarize the current knowledge of the involvement of nestin in breast cancer (BC) pathogenesis. ...In normal breast tissue, nestin is expressed in the basal/myoepithelial cells of the mammary gland. In BC, nestin identifies basal-like tumours and predicts aggressive behaviour and poor prognosis. ...
The aim of the present review was to summarize the current knowledge of the involvement of nestin in breast cancer (BC) pathogenesis. …
Nestin Improves Preeclampsia-Like Symptoms by Inhibiting Activity of Cyclin-Dependent Kinase 5.
Yang X, et al. Kidney Blood Press Res 2018. PMID 29689548 Free article.
Nestin, a cytoskeleton protein, is expressed stably in podocytes. However, the association between the Nestin concentration in urine and the progression of PE and the role of Nestin in PE remains unclear. ...Ang II treatment decreased the expression of Nestin and Podocin in a time- and dose- dependent manner in podocytes. Restoration of the Nestin levels could reverse Ang II-induced F-actin degradation and attenuate Ang II-mediated podocyte apoptosis, while knockdown of the Nestin level exhibited the opposite. ...
Nestin, a cytoskeleton protein, is expressed stably in podocytes. However, the association between the Nestin concentration in
Morphine delays neural stem cells differentiation by facilitating Nestin overexpression.
Jimenez-Gonzalez A, et al. Biochim Biophys Acta Gen Subj 2018. PMID 29111275
RESULTS: Morphine increases GFP in nestin:GFP embryos and overexpresses the NSC marker Nestin. Morphine also exerts a hyperacetylation effect on H3K27 and decreases DNA methylation within a region located 18 Kb upstream nestin transcription starting site. ...It has also been demonstrated that nestin levels depend on p300 activity. The facilitated Nestin expression delays the normal differentiation of neural stem cells. ...
RESULTS: Morphine increases GFP in nestin:GFP embryos and overexpresses the NSC marker Nestin. Morphine also exerts a hyperace …
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